Maternal smoking in pregnancy alters neonatal cytokine responses

Noakes, Paul S.; Holt, Patrick G.; Prescott, Susan L.

doi:10.1034/j.1398-9995.2003.00290.x

Cited by 198 publications

(145 citation statements)

References 45 publications

(52 reference statements)

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“…While smokers are notoriously susceptible to infections and exhibit diminished cell-mediated immunity [Sopori 2002] they also present with higher levels of inflammatory diseases [Kitamura and Kasai 2007], autoantibody production, leukoctyosis, and increased risk of rheumatoid arthritis, systemic lupus erythematosus and Graves' disease [Costenbader and Karlson 2006;Klareskog et al 2007;Vestergaard et al 2002]. Maternal smoking during pregnancy is associated with higher cord blood IgE (which does not cross the placenta) [Magnusson 1986], stronger neonatal lymphoproliferation [Noakes et al 2003], and increased rates of asthma and allergy in children [Gilliland et al 2001;Magnusson 1986]. In mice, cigarette smoke stimulated oligoclonal expansion of T lymphocytes, leading to a persistent, adaptive T cell immune response [Motz et al 2008] and in utero exposure resulted in elevated levels of circulating white blood cells in the offspring [Ng and Zelikoff 2008].…”

Section: Cigarette Smoke Pahs Ahr and The Immune Systemmentioning

confidence: 99%

Embryonic Resorption and Polycyclic Aromatic Hydrocarbons: Putative Immune-mediated Mechanisms

Detmar

Jurisicova

2010

Systems Biology in Reproductive Medicine

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Polycyclic aromatic hydrocarbons (PAHs) are released into the environment as a result of incomplete fossil fuel combustion from industrial furnaces, woodburning stoves, and automobile exhaust fumes; however, the primary source of human exposure to these compounds is cigarette smoke. Embryonic and fetal loss after treatment with high doses of PAHs have been well documented in animal studies; however, few studies have addressed the reproductive consequences of long-term, low-level exposure to these chemicals. We previously reported that low doses of PAHs administered to ICR mice over a period of 9 weeks prior to conception resulted in early embryonic resorptions, whereby treated dams lost approximately 50% of their litter. During the course of these studies, we observed greater numbers of infiltrating uterine natural killer (uNK) cells into the placenta of PAH-exposed conceptuses. While exposure to high levels of PAHs has been shown to be immunosuppressive, increasing evidence suggests that chronic, low-dose exposure to PAHs may stimulate immune cells. Thus, we hypothesized that low-dose, chronic PAH exposure in our mouse model is mediating embryonic resorption by hyperstimulating maternal immune cells. In this review of the literature, we outline the rationale of our argument and present preliminary data, focussing upon PAH-mediated alterations in uNK cell dynamics and how these changes may be linked to early embryonic resorptions.

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Section: Cigarette Smoke Pahs Ahr and The Immune Systemmentioning

confidence: 99%

Embryonic Resorption and Polycyclic Aromatic Hydrocarbons: Putative Immune-mediated Mechanisms

Detmar

Jurisicova

2010

Systems Biology in Reproductive Medicine

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“…12 Mothers who smoked while pregnant gave birth to children with a greater risk of wheezing and asthma, and it was found that they had elevated IgE and IL-13 levels, but low IL-4 and IFN-γ levels, in cord blood, reduced airway caliber and reduced pulmonary function. [13][14][15] During the perinatal period, exclusive breastfeeding for the first 4 months of life may be a protective factor against wheezing; other studies have not however confirmed this hypothesis. 16,17 Respiratory viruses, such as syncytial respiratory virus, rhinovirus, metapneumovirus, parainfluenza type 3 and influenza are associated with increased risk of wheezing among preschool children.…”

Section: Epidemiology and Factors Associated With Wheezing In Preschomentioning

confidence: 89%

Sibilância no lactente: epidemiologia, investigação e tratamento

Neto¹

2010

J. Pediatr. (Rio J.)

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Objective: To perform a review of the epidemiological aspects of investigating and treating wheezing in infants.Sources: A search was run on MEDLINE using the keywords "wheezing," "infants," "diagnosis," "treatment," and "children," and Google was also used to search for "Estudio Internacional de Sibilancias en Lactantes." Summary of the findings:The prevalence of wheezing in infants varies greatly around the world. The factors associated with wheezing in infants are different at different research centers. Treatment of wheezing infants is still controversial and is dependent on a precise diagnosis. Clinical history and physical examination are fundamental to diagnosis. Conclusions:A standardized method could reveal data of relevance to the epidemiology and treatment of wheezing in Brazil and allow comparisons between different participating centers.

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“…19 Induce cambios en el crecimiento pulmonar, hiperreactividad de las vías respiratorias, deterioro de la adaptación inmune a los patógenos virales, disminución del desarrollo del sistema inmune pulmonar y cambios inmunológicos que favorecen el desarrollo de la enfermedad alérgica. 20 Además, la inducción de estrés oxidativo y las modificaciones en la colonización bacteriana de las mucosas provocan mayor penetración de alérgenos. 21 La exposición posnatal inmediata se asocia con sibilancias en lactantes y aumento de la prevalencia de asma, independientemente del efecto de la exposición durante la gestación.…”

Section: Humo Del Tabacounclassified

Prevención de las enfermedades alérgicas en la infancia: entre la teoría y la realidad

2016

Arch Argent Pediat

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RESUMENLas enfermedades alérgicas tienen una prevalencia creciente de modo universal y ocasionan alto impacto sanitario. La investigación está dirigida al estudio de los factores etiológicos y de riesgo de estas enfermedades, que pueden ser potencialmente modificados con estrategias de prevención primaria, secundaria y terciaria. Muchas de esas medidas no tienen un efecto comprobado de manera definitiva, dado que se realizan en un contexto controlado diferente a lo que ocurre en la vida real. Este documento tiene por objetivo revisar las evidencias más actuales sobre prevención de las enfermedades alérgicas considerando las certezas y cuestiones por resolver, y está especialmente centrado en las medidas ambientales, dietéticas, farmacológicas e inmunológicas para los distintos niveles preventivos. Es imperativo un mejor conocimiento de genes y factores ambientales responsables de las enfermedades alérgicas para optimizar las medidas preventivas que permitan revertir la creciente prevalencia de estas enfermedades en la infancia. Palabras clave: alergia, prevención, asma, control ambiental, inmunoterapia. ABSTRACTAllergic diseases have an increasing worldwide prevalence and a great impact on the health related costs. The research is focused on the study of etiological and risk factors of allergic diseases that can potentially be modified with primary, secondary and tertiary prevention strategies. Many of these measures do not have a definitively proven effect taking place in a controlled context different to what happens in real life. This paper aims to review the latest evidence on prevention of allergic diseases considering certainties and unresolved issues and focuses mainly on environmental, dietary, pharmacological and immunological preventive strategies for different levels of prevention. It is imperative to have a better understanding of genetic and environmental factors that cause allergic diseases to optimize preventive measures that are effective in reversing the increasing trend in the prevalence of allergic illnesses in childhood. Key words : allergy, prevention, asthma, environmental control, immunotherapy. http://dx.doi.org/10.5546/aap.2016.277 INTRODUCCIÓNL a s e n f e r m e d a d e s a l é r g i c a s constituyen las patologías crónicas más frecuentes en la edad pediátrica, c o n e l e v a d o s c o s t o s s a n i t a r i o s para el diagnóstico y tratamiento y afectación de la calidad de vida.1 . En Latinoamérica, aproximadamente el Comité Nacional de Alergia Documento de toma de posición Documento desarrollado en el marco del 50° aniversario del

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Maternal smoking in pregnancy alters neonatal cytokine responses

Abstract: These findings indicate that maternal cigarette smoking can modify aspects of fetal immune function and highlight the need for further studies in this area.

Cited by 198 publications

References 45 publications

Embryonic Resorption and Polycyclic Aromatic Hydrocarbons: Putative Immune-mediated Mechanisms

Embryonic Resorption and Polycyclic Aromatic Hydrocarbons: Putative Immune-mediated Mechanisms

Sibilância no lactente: epidemiologia, investigação e tratamento

Prevención de las enfermedades alérgicas en la infancia: entre la teoría y la realidad

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