Maternal smoking habits and congenital malformations: a population study.

Evans, Douglas R.; Newcombe, R. G.; Campbell, Harry

doi:10.1136/bmj.2.6183.171

Cited by 95 publications

(29 citation statements)

References 5 publications

(1 reference statement)

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“…[9][10][11][12] Although some early small studies showed an increased risk of neural tube defects associated with maternal smoking, 13 this finding has not been supported by more recent studies. Pregnancies affected by either anencephaly or spina bifida have high rates of spontaneous abortion, and the likelihood of spontaneous abortion of affected fetuses may be increased among women who smoke.…”

Section: Discussionmentioning

confidence: 99%

Maternal smoking and birth defects: Validity of birth certificate data for effect estimation

Honein¹,

Paulozzi²,

Watkins³

2001

Public Health Reports

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SYNOPSISObjectives. The authors sought to assess the validity of birth certificate data for estimating the association between maternal smoking and birth defects. The US standard birth certificate includes check boxes for maternal smoking and for 21 congenital anomalies. The sensitivity and specificity of birth certificate data have been studied, but previous studies have not addressed the validity of these data for estimating the association between birth defects and maternal smoking or other risk factors.Methods. US public-use natality data (1997)(1998) were used to calculate the prevalence ratio (adjusted for maternal age, race/ethnicity, and education) for the association between maternal smoking and 13 defects/defect categories. All analyses were restricted to 45 states, New York City, and the District of Columbia because they collect both maternal smoking and birth defect data.Results. Maternal smoking was associated with an increased prevalence of hydrocephaly (adjusted prevalence ratio [PR] = 1.24; 95% confidence interval [CI] = 1.08,1.43), microcephaly (PR 1.47; 95% CI 1.15,1.88), omphalocele/ gastroschisis (PR 1.37; 95% CI 1.22,1.53), cleft lip/palate (PR 1.35; 95% CI 1.25,1.45), clubfoot (PR 1.62; 95% CI 1.49,1.75), and polydactyly/syndactyly/ adactyly (PR 1.33; 95% CI 1.23,1.43 ). Previous studies have indicated an association between maternal smoking and gastroschisis, oral clefts, and clubfoot with effect estimates of similar magnitude to this study.Conclusions. These findings suggest that birth certificate data may be useful for exploratory or corroborative studies estimating the association between birth defects and some risk factors recorded on birth certificates.

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Section: Discussionmentioning

confidence: 99%

Maternal smoking and birth defects: Validity of birth certificate data for effect estimation

Honein¹,

Paulozzi²,

Watkins³

2001

Public Health Reports

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“…Some studies have shown an elevated risk of oral clefts with tobacco smoking during pregnancy, [1][2][3][4][5][6][7][8][9][10] whereas other studies have not. [11][12][13][14][15] A recent meta-analysis 16 estimated, for both types of clefts (cleft lip with or without cleft palate and cleft palate only), a small but significant increase in risk; the existence of a dose-response effect is still controversial.…”

mentioning

confidence: 99%

Tobacco and alcohol use during pregnancy and risk of oral clefts. Occupational Exposure and Congenital Malformation Working Group

Lorente

Cordier²,

Goujard³

et al. 2000

Am J Public Health

107

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Objectives. This study examined the relationship between maternal tobacco and alcohol consumption during the first trimester of pregnancy and oral clefts.Methods. Data were derived from a European multicenter case-control study including 161 infants with oral clefts and 1134 control infants.Results. Multivariate analyses showed an increased risk of cleft lip with or without cleft palate associated with smoking (odds ratio [OR] = 1.79, 95% confidence interval [CI] = 1.07, 3.04) and an increased risk of cleft palate associated with alcohol consumption (OR = 2.28, 95% CI = 1.02, 5.09). The former risk increased with the number of cigarettes smoked.Conclusions. This study provides further evidence of the possible role of prevalent environmental exposures such as tobacco and alcohol in the etiology of oral clefts.

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“…While several studies have reported positive associations between smoking and specific malformations, 4 particularly oral clefts,9' others did not find such relationships. [12][13][14][15][16][17][18][19][20][21] In this study, we examined the association between cigarette smoking and oral clefts using data from the Maryland Birth Defects Reporting and Information System (BDRIS). We discuss the importance of grouping malformations into homogeneous categories"' in etiologic studies.…”

Section: Introductionmentioning

confidence: 99%

Maternal cigarette smoking and oral clefts: a population-based study.

et al. 1987

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Analyses of 1984 data from the Maryland Birth Defects Reporting and Information System indicate that mothers of infants with oral clefts (cleft lip with or without cleft palate; and cleft palate) smoked more during pregnancy than mothers of infants with other defects (odds ratio OR of 2.56 and 2.39, respectively). There was a dose-response relation between the daily amount smoked and the risk of clefting. Adjustment for available confounding variables did not account for the association between smoking and oral clefts. (Am J Public Health 1987; 77:623-625.)

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Maternal smoking habits and congenital malformations: a population study.

Cited by 95 publications

References 5 publications

Maternal smoking and birth defects: Validity of birth certificate data for effect estimation

Maternal smoking and birth defects: Validity of birth certificate data for effect estimation

Tobacco and alcohol use during pregnancy and risk of oral clefts. Occupational Exposure and Congenital Malformation Working Group

Maternal cigarette smoking and oral clefts: a population-based study.

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