Maternal smoking, birth weight, infant death, and the self-selection problem

Hickey, Richard J.; Clelland, Richard C.; Bowers, Evelyn J.

doi:10.1016/0002-9378(78)90253-3

Cited by 28 publications

(5 citation statements)

References 46 publications

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“…In fact, conditions associated with fetal hypoxia, such as placental insufficiency, living at high altitude, anemia, pulmonary diseases, preeclampsia, and smoking, have also been associated with IUGR. 140,141 By exposing pregnant Sprague-Dawley rats to a hypoxic environment (12% oxygen) during the last third of pregnancy (day 15 to 21), our group has previously shown (ex vivo) that IUGR rat offspring demonstrate several cardiac structural and functional changes during adulthood. These include increased expression of collagen type I and III fibers, altered ß/a myosin heavy chains ratio (ß/ aMHC), increased susceptibility to ischemia reperfusion injury, decreased activity of matrix metalloproteinase 2, 70 and the development of ventricular hypertrophy, diastolic dysfunction, and pulmonary hypertension with age.…”

Section: Animal Species Used To Study Early Programmingmentioning

confidence: 99%

The Early Origins of Cardiovascular Health and Disease: Who, When, and How

2011

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Almost 30 years ago, a series of epidemiological studies popularized the early programming theory that had resulted from observed associations between low birthweight and increased cardiovascular morbidity and mortality later in life. Since then, several clinical and experimental models have been created to understand the principles and mechanisms of this fascinating phenomenon and describe its relevance to the pathophysiology of cardiovascular and many other chronic diseases. Despite the growing body of published evidence, the specific mechanisms mediating early programming effects are still elusive. Moreover, many controversial issues have arisen regarding the characteristics of the most commonly used clinical and experimental models, the existence of potential windows of susceptibility for different organs, and the presence of sex differences in its pathophysiology. Therefore, this review synthesizes some of the antecedents behind the early programming theory and discusses some of the controversial issues surrounding it. Early programming has been extensively linked to several chronic diseases; however, for the purposes of this review we have concentrated on the potential role of this entity in the pathophysiology of chronic cardiovascular diseases.

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Section: Animal Species Used To Study Early Programmingmentioning

confidence: 99%

The Early Origins of Cardiovascular Health and Disease: Who, When, and How

2011

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“…[1][2][3][4][5] A number of environmental and maternal factors, including high altitudes, smoking, anemia, preeclampsia, pulmonary diseases, and placental dysfunction or umbilical cord problems, can cause intrauterine hypoxia. [6][7][8] In turn, hypoxia in utero plays critical roles in inducing fetal growth restriction (FGR) 9 and affecting the development of fetal important organs such as the kidney. 10,11 Previous studies showed that nephrogenesis could be disturbed by intrauterine hypoxia, leading to a low nephron endowment.…”

Section: Introductionmentioning

confidence: 99%

Prenatal Exposure to Hypoxia Induced Beclin 1 Signaling-Mediated Renal Autophagy and Altered Renal Development in Rat Fetuses

Xia

Gao

et al. 2015

Reprod. Sci.

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“…Intrauterine hypoxia, the most common complication during pregnancy, can be caused by smoking (Hickey et al, 1978), maternal anemia (Soares et al, 2017), or eclampsia (Ramjiawan and Tappia, 2018). To analyze the effect of antenatal hypoxia specifically, we used the previously established intrauterine-hypoxia model (Li et al, 2017).…”

Section: Discussionmentioning

confidence: 99%

Analyzing the Effects of Intrauterine Hypoxia on Gene Expression in Oocytes of Rat Offspring by Single Cell Transcriptome Sequencing

Liu

Yue

et al. 2019

Front. Genet.

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Intrauterine hypoxia is one of the most frequently occurring complications during pregnancy, and the effects of antenatal hypoxia in offspring are not restricted to the perinatal period. Previous studies have reported on this phenomenon, which is usually described as multigenerational or transgenerational inheritance. However, the exact mechanism of this type of inheritance is still not clear. Therefore, in the present study, we investigated the alteration in the gene expression of oocytes, derived from intrauterine hypoxia rats and their offspring, by transcriptome sequencing. Our results showed that 11 differentially expressed genes were inherited from the F1 to F2 generation. Interestingly, these differentially expressed genes were enriched in processes predominantly involved in lipid and insulin metabolism. Overall, our data indicated that alteration in the gene expression of oocytes may be associated with some metabolic diseases and could potentially be the basis of transgenerational or multigenerational inheritance, induced by an adverse perinatal environment.

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Maternal smoking, birth weight, infant death, and the self-selection problem

Cited by 28 publications

References 46 publications

The Early Origins of Cardiovascular Health and Disease: Who, When, and How

The Early Origins of Cardiovascular Health and Disease: Who, When, and How

Prenatal Exposure to Hypoxia Induced Beclin 1 Signaling-Mediated Renal Autophagy and Altered Renal Development in Rat Fetuses

Analyzing the Effects of Intrauterine Hypoxia on Gene Expression in Oocytes of Rat Offspring by Single Cell Transcriptome Sequencing

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