Maternal sleep deprivation is a risk factor for small for gestational age: A cohort study

Abeysena, Chrishantha; Jayawardana, Pushpa; Seneviratne, Rohini De Alwis

doi:10.1111/j.1479-828x.2009.01010.x

Cited by 80 publications

(94 citation statements)

References 36 publications

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“…Although the role played by oscillatory gene expression and circadian clocks during pregnancy remains unclear, gestational chronodisruption may be regarded as an adverse prenatal condition given that increased risk of miscarriage, preterm delivery, and low birth weight have been consistently reported in shift worker women (1,8,9,21,53). In fact, despite the fetal suprachiasmatic nucleus not yet being the master circadian clock (at least in the conventional way it works during adulthood), several fetal organs seem to operate as peripheral oscillators in the rat (see Refs.…”

Section: Discussionmentioning

confidence: 99%

Gestation under chronic constant light leads to extensive gene expression changes in the fetal rat liver

Spichiger

Torres-Farfán

Galdames

et al. 2015

Physiological Genomics

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Recent reports account for altered metabolism in adult offspring from pregnancy subjected to abnormal photoperiod, suggesting fetal programming of liver physiology. To generate a pipeline of subsequent mechanistic experiments addressing strong candidate genes, here we investigated the effects of constant gestational light on the fetal liver transcriptome. At 10 days of gestation, dams were randomized in two groups ( n = 7 each): constant light (LL) and normal photoperiod (12 h light/12 h dark; LD). At 18 days of gestation, RNA was isolated from the fetal liver and subjected to DNA microarray (Affymetrix platform for 28,000 genes). Selected differential mRNAs were validated by quantitative PCR (qPCR), while integrated transcriptional changes were analyzed with Ingenuity Pathway Analysis and other bioinformatics tools. Comparison of LL relative to LD fetal liver led to the following findings. Significant differential expression was found for 3,431 transcripts (1,960 upregulated and 1,471 downregulated), with 393 of them displaying ≥ 1.5-fold change. We validated 27 selected transcripts by qPCR, which displayed fold-change values highly correlated with microarray ( r2 = 0.91). Different markers of nonalcoholic fatty liver disease were either upregulated (e.g., Ndn and Pnpla3) or downregulated (e.g., Gnmt, Bhmt1/2, Sult1a1, Mpo, and Mat1a). Diverse pathways were altered, including hematopoiesis, coagulation cascade, complement system, and carbohydrate and lipid metabolism. The microRNAs 7a-1, 431, 146a, and 153 were upregulated, while the abundant hepatic miRNA 122 was downregulated. Constant gestational light induced extensive modification of the fetal liver transcriptome. A number of differentially expressed transcripts belong to fundamental functional pathways, potentially contributing to long-term liver disease.

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Section: Discussionmentioning

confidence: 99%

Gestation under chronic constant light leads to extensive gene expression changes in the fetal rat liver

Spichiger

Torres-Farfán

Galdames

et al. 2015

Physiological Genomics

View full text Add to dashboard Cite

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“…[2] In contrast, rotating shift work exposure can compromise the health of early middle-aged female workers, [3][4][5] an important population giving birth in industrialized countries. Although studies in some workplace settings have found adverse effects of shift work exposure on reproductive disorders of female employees [6,7] and on birth weight of fetuses, [8,9] few studies have investigated these effects in semiconductor manufacturing factories.…”

Section: Introductionmentioning

confidence: 98%

Effect of rotating shift work on childbearing and birth weight: a study of women working in a semiconductor manufacturing factory

et al. 2011

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“…In this context, chronodisruption (i.e., a significant disturbance of the temporal organization of endocrinology, physiology, metabolism and behavior) along pregnancy has been associated with an increased risk not only of miscarriage, but also preterm delivery and low birth weight [2]–[5]; both strong predictors of chronic disease later in life [6]–[7]. Conceivable, both the maternal and fetal circadian system are the targets of developmental chronodisruption.…”

Section: Introductionmentioning

confidence: 99%

Timed Maternal Melatonin Treatment Reverses Circadian Disruption of the Fetal Adrenal Clock Imposed by Exposure to Constant Light

et al. 2012

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Surprisingly, in our modern 24/7 society, there is scant information on the impact of developmental chronodisruption like the one experienced by shift worker pregnant women on fetal and postnatal physiology. There are important differences between the maternal and fetal circadian systems; for instance, the suprachiasmatic nucleus is the master clock in the mother but not in the fetus. Despite this, several tissues/organs display circadian oscillations in the fetus. Our hypothesis is that the maternal plasma melatonin rhythm drives the fetal circadian system, which in turn relies this information to other fetal tissues through corticosterone rhythmic signaling. The present data show that suppression of the maternal plasma melatonin circadian rhythm, secondary to exposure of pregnant rats to constant light along the second half of gestation, had several effects on fetal development. First, it induced intrauterine growth retardation. Second, in the fetal adrenal in vivo it markedly affected the mRNA expression level of clock genes and clock-controlled genes as well as it lowered the content and precluded the rhythm of corticosterone. Third, an altered in vitro fetal adrenal response to ACTH of both, corticosterone production and relative expression of clock genes and steroidogenic genes was observed. All these changes were reversed when the mother received a daily dose of melatonin during the subjective night; supporting a role of melatonin on overall fetal development and pointing to it as a ‘time giver’ for the fetal adrenal gland. Thus, the present results collectively support that the maternal circadian rhythm of melatonin is a key signal for the generation and/or synchronization of the circadian rhythms in the fetal adrenal gland. In turn, low levels and lack of a circadian rhythm of fetal corticosterone may be responsible of fetal growth restriction; potentially inducing long term effects in the offspring, possibility that warrants further research.

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Maternal sleep deprivation is a risk factor for small for gestational age: A cohort study

Cited by 80 publications

References 36 publications

Gestation under chronic constant light leads to extensive gene expression changes in the fetal rat liver

Gestation under chronic constant light leads to extensive gene expression changes in the fetal rat liver

Effect of rotating shift work on childbearing and birth weight: a study of women working in a semiconductor manufacturing factory

Timed Maternal Melatonin Treatment Reverses Circadian Disruption of the Fetal Adrenal Clock Imposed by Exposure to Constant Light

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