Maternal Serum Zinc Level and Pre-eclampsia Risk in African Women: a Systematic Review and Meta-analysis

Tesfa, Endalamaw; Nibret, Endalkachew; Munshea, Abaineh

doi:10.1007/s12011-021-02611-7

Cited by 8 publications

(7 citation statements)

References 41 publications

(47 reference statements)

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“…Women with pre-eclampsia had lower zinc concentrations compared to healthy pregnant controls (SMD -0.587, 95%CI: -0.963 to -0.212, 1091 participants, 14 studies, I 2 88%), measured largely in the third trimester (36). Significantly lower zinc concentrations among pre-eclamptic women compared to healthy controls were only found in Asia (36,74,75) and sub-Saharan Africa (76), not in other regions of the world.…”

Section: Definite Associationsmentioning

confidence: 94%

An evidence review and nutritional conceptual framework for pre-eclampsia prevention

et al. 2022

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Pre-eclampsia is a serious complication of pregnancy, and maternal nutritional factors may play protective roles or exacerbate risk. The tendency to focus on single nutrients as a risk factor obscures the complexity of possible interactions, which may be important given the complex nature of pre-eclampsia. An evidence review was conducted to compile definite, probable, possible and indirect nutritional determinants of pre-eclampsia to map a nutritional conceptual framework for pre-eclampsia prevention. Determinants of pre-eclampsia were first compiled through an initial consultation with experts. Secondly, an expanded literature review was conducted to confirm associations, elicit additional indicators and evaluate evidence. The strength of association was evaluated as definite RR<0.40 or ≥3.00, probable RR 0.40-0.69 or 1.50-2.99, possible RR 0.70-0.89 or 1.10-1.49 or not discernible RR 0.90-1.09. The quality of evidence was evaluated using GRADE. Twenty-five nutritional factors were reported in two umbrella reviews and 22 meta-analyses. Of these, 14 were significantly associated with pre-eclampsia incidence. Maternal vitamin D deficiency and higher serum iron emerged as definite nutritional risk factors for pre-eclampsia incidence across populations, while low serum zinc was a risk factor in Asia and Africa. Calcium and/or vitamin D supplementation were probable protective nutritional factors. Healthy maternal dietary patterns were possibly associated with lower risk of developing pre-eclampsia. Potential indirect pathways of maternal nutritional factors and pre-eclampsia may exist through obesity, maternal anaemia and gestational diabetes mellitus. Research gaps remain on the influence of household capacities and sociocultural, economic and political contexts, as well as interactions with medical conditions.

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Section: Definite Associationsmentioning

confidence: 94%

An evidence review and nutritional conceptual framework for pre-eclampsia prevention

et al. 2022

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“…Several studies have found significantly lower level of serum zinc in preeclampsia patients compared with pregnancies without preeclampsia. 6 In this study, the average zinc levels of PE patients were 43.90 ± 15.79 mcg/dL (15-86 mcg/ dL), significantly lower than patients without preeclampsia which was 48.77 ± 10.54 mcg/dL (22-83 mcg/dL).…”

Section: Characteristicmentioning

confidence: 51%

“…Research on Indians found that serum zinc levels in mild and severe preeclampsia women were lower at 12.72 μmol/L in mild preeclampsia and 12.04 μmol/L in severe preeclampsia compared with 15.64 μmol/L in normal pregnancy. [5][6][7][8] Research related with the benefits of zinc in preeclampsia had not been conducted in Indonesia, especially in dr. Mohammad Hoesin General Hospital Palembang. Because of that, authors are interested in proving the relationship between zinc and preeclampsia in the pregnant women population at dr. Mohammad Hoesin General Hospital Palembang.…”

Section: Introductionmentioning

confidence: 99%

Level of maternal zinc serum as risk factor of preeclampsia

Kaprianti¹,

Mirani²,

Martadiansyah³

et al. 2022

Indones J Obstet Gynecol

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Objective : To know the relationship of serum zinc levels with preeclampsia (PE) Method: This observational research uses a type of case control research. The population of this study is all pregnant women with a single pregnancy, gestational age of 28-42 weeks who were treated at the Department of Obstetrics and Gynecology of RSUP Dr. Mohammad Hoesin Palembang from August 2020 to November 2020. The study divided into 2 group, a case group of 30 pregnant women with PE and a control group of 60 pregnant women non PE. Serum zinc level examination is performed on all samples that match the research criteria. The data is processed by using SPSS software program version 20.0 Windows. Result: Both case and control groups had no meaningful differences to the general characteristics of the patient. There were significant differences in average zinc levels of maternal serum in both research groups (p=0.013; 43.90 plus-minus 15.79 pg/dL). The value of serum zinc levels that have the best sensitivity and specificity is at 45.5 pg/dL. Conclusion: There is a meaningful relationship between serum zinc levels and PE events. Pregnant women with serum zinc levels greater than or equal to 45.5 pg /dL were significantly at 3.2 times more risk of PE than pregnant women with serum zinc levels less than or equal to 45.5 pg/dL. In this case it is necessary to supplement zinc earlier in pregnancy to reduce the risk of preeclampsia. Keywords: preeclampsia, zinc, case-control studies

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“…13 Zinc plays a function in placental morphogenesis and the regulation of maternal blood pressure during pregnancy, which means that a zinc deficit impairs fetal growth and results in blood pressure problems. 14 In addition, low serum Zn levels lead to oxidative stress and lower superoxide dismutase activity, both of which increase blood pressure due to increased Zn transfer from the mother to the developing fetus, low Zn levels, and higher urine Zn excretion in preeclampsia females. On the other hand, preeclampsia's enhanced lipid peroxidation lowers the amounts of transporter proteins and estrogens, which lowers serum Zn levels.…”

Section: Discussionmentioning

confidence: 99%

The Role of Zinc-Rich Food Consumption on Zinc Level and the Incident of Preeclampsia

Hartono

Lukas²,

Mappaware³

et al. 2023

Obgynia

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Objective: Investigate the correlation between dietary intake of zinc, preeclampsia and blood zinc levels. Methods: This study, which compared pregnant women in the third trimester at the Wahidin Sudirohusodo Hospital and the educational network hospital with and without preeclampsia, used a Cross Sectional methodology. Zinc level testing was carried out at Prodia using ICP-MS method. Mann Whitney, Kruskal Wallis, and chi square tests were used to examine the data. Results: Preeclampsia group (n=38) and control group (n=40) were two groups made up of a total of 78 pregnant women. Zn level of severe preeclampsia (47.73 ± 11.23 ng/mL) was lower than preeclampsia (50.50 ± 13.59 ng/mL) and non-preeclampsia (50.58 ± 10.12ng/mL), but not significantly. Lower zinc rich-food consumption was a significant effect on zinc deficiency (p< 0.05), and was no significant effect on preeclampsia (p > 0.05). Conclusion: Low intake of zinc-rich foods and occasionally exposure to cigarette smoke are the causes of zinc insufficiency in third trimester pregnancy, but has little impact on the occurrence of preeclampsia. Peranan Konsumsi Makanan Kaya Zink terhadap Kadar Zink dan Insiden Preeklamsia Abstrak Tujuan: Mengetahui korelasi antara asupan zink, preeklamsia dan tingkat zink serum. Metode: Penelitian ini membandingkan ibu hamil trimester III di RS Wahidin Sudirohusodo dan RS jejaring pendidikan dengan dan tanpa preeklampsia menggunakan metodologi Cross Sectional. Pengujian kadar zink dilakukan di Prodia dengan menggunakan metode ICP-MS. Uji Mann Whitney, Kruskal Wallis dan Chi Square digunakan untuk menganalisis data. Hasil: Kelompok preeklamsia (n=38) dan kelompok kontrol (n=40) adalah dua kelompok yang terdiri dari total 78 ibu hamil. Kadar Zn preeklamsia berat (47.73 ± 11.23 ng/mL) lebih rendah dibandingkan preeklamsia (50.50 ± 13.59 ng/mL) dan non preeklamsia (50.58 ± 10.12ng/mL), tetapi tidak bermakna. Rendahnya konsumsi makanan kaya zink berpengaruh signifikan terhadap defisiensi zink (p<0.05), namun tidak signifikan terhadap kejadian preeklamsia (p>0.05). Kesimpulan: Diet rendah zink dan paparan asap rokok adalah penyebab defisiensi zink pada kehamilan trimester III, tetapi memiliki dampak kecil terhadap insiden preeklamsia. Kata kunci: preeklamsia, kehamilan, zink

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Maternal Serum Zinc Level and Pre-eclampsia Risk in African Women: a Systematic Review and Meta-analysis

Cited by 8 publications

References 41 publications

An evidence review and nutritional conceptual framework for pre-eclampsia prevention

An evidence review and nutritional conceptual framework for pre-eclampsia prevention

Level of maternal zinc serum as risk factor of preeclampsia

The Role of Zinc-Rich Food Consumption on Zinc Level and the Incident of Preeclampsia

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