Maternal Serum Leptin Concentrations Do Not Correlate With Cord Blood Leptin Concentrations in Normal Pregnancy

Laml, Thomas; Hartmann, Beda; Ruecklinger, E.; Preyer, Oliver; Soeregi, Gabor; Wagenbichler, P

doi:10.1177/107155760100800108

Cited by 19 publications

(16 citation statements)

References 25 publications

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“…In our study, cord blood leptin showed significant correlation with birth weight, gestational age, length, head circumference, triceps skinfold thickness, and fat mass. In agreement with the results of Laml et al [25] , we did not find any correlation between maternal leptin concentrations and leptin concentrations in cord blood.…”

Section: Discussionsupporting

confidence: 83%

The Relationship between Birth Weight Leptin and Bone Mineral Status in Newborn Infants

Akçakuş¹,

Kurtoğlu²,

Köklü³

et al. 2006

Neonatology

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Background: The positive relationship between fat mass, bone mass and leptin has been shown in fetal mouse cartilage/bone. It has been shown that umbilical venous leptin predicts both the size of the neonatal skeleton and its estimated volumetric mineral density. Aims: This study investigates how birth weight and bone mineralization correlate with leptin levels. In addition, we aimed to determine the predictive value of anthropometrics measurements and gender on variability in bone mineral status. Methods: Umbilical cord venous blood samples were obtained at the delivery from 100 term newborn infants. Forty of the newborn infants had birth weights appropriate for gestational age (AGA), 30 were small for gestational age (SGA) and 30 were large for gestational age (LGA). Data were acquired using the whole body dual energy X-ray obsorptiometry scanner in the first 24 h after birth. Results: Leptin concentrations were higher in LGA (36.6 ±12.0 ng/ml; p < 0.0001), but lower in SGA (11.7 ± 5.6 ng/ml; p < 0.001) than in AGA infants (20.3 ± 7.6 ng/ml). Whole body bone mineral density and whole body bone mineral content were higher in LGA babies (0.442 ± 0.025 g/cm², 71.6 ± 9.0 g, p < 0.01, p < 0.001, respectively) but lower in SGA (0.381 ± 0.027 g/cm², 29.1 ± 9.1 g, p < 0.001, p < 0.001, respectively) than in AGA babies (0.426 ± 0.022 g/cm², 53.7 ± 9.6 g, respectively). The percentage of whole body bone mineral content was lower in SGA (1.3 ± 0.3) than in AGA (1.6 ± 0.2, p < 0.001) and LGA (1.7 ± 0.2, p < 0.001). In stepwise linear regression analyses models; leptin is not found related to the bone indices. Conclusion: Our study does not provide support for the hypothesis that leptin may play a major role in the regulation of bone metabolism in the developing skeleton.

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Section: Discussionsupporting

confidence: 83%

The Relationship between Birth Weight Leptin and Bone Mineral Status in Newborn Infants

Akçakuş¹,

Kurtoğlu²,

Köklü³

et al. 2006

Neonatology

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“…We observed no correlation between maternal and cord blood leptin levels supporting the independence of maternal and fetal leptin levels and thus the concept of the "two-compartment model" of feto-placental leptin regulation (24). Furthermore, we could confirm the previously reported gender-difference in fetal leptin concentrations (8,25-28) which could not be explained by different amounts of newborn fat mass and thus might be due to hormonal differences already present at birth (29).…”

Section: Discussionsupporting

confidence: 78%

Effect of reducing the n‐6/n‐3 fatty acid ratio on the maternal and fetal leptin axis in relation to infant body composition

Brunner

Schmid

Hüttinger

et al. 2013

Obesity

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Objective: To investigate the effect of reducing the n-6/n-3 fatty acid ratio in maternal nutrition on the maternal and cord blood leptin axis and their association with infant body composition up to 2 years. Design and Methods: 208 healthy pregnant women were randomized to either a dietary intervention to reduce the n-6/n-3 fatty acid ratio from 15th week of gestation until 4 months postpartum or a control group. Leptin, soluble leptin receptor and free leptin index were determined in maternal and cord plasma and related to infant body composition assessed by skinfold thicknesses up to 2 years. Results: The intervention had no effect on either the maternal or fetal leptin axis. Maternal leptin in late pregnancy was inversely related to infant weight and lean body mass (LBM) up to 2 years, after multiple adjustments. Cord leptin was positively related to weight, body fat, and LBM at birth, and inversely associated with weight, BMI, fat mass, and LBM at 2 years and weight gain up to 2 years. The contribution of cord leptin to infant outcomes was overall stronger compared with maternal leptin. Conclusions: Both, maternal and fetal leptin were associated with subsequent infant anthropometry with a greater impact of fetal leptin.

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“…Abstracts from the remaining 99 citations were retrieved for evaluation and 25 additional studies were excluded, leaving 74 articles to be studied using the full text. Of these, 34 were excluded resulting in 40 studies consistent with the criteria set for the meta‐analysis 20–59 . In addition, four studies 60–63 were identified through hand search of the reference lists of the retrieved articles, resulting in the final number of 44 articles included in the meta‐analysis.…”

Section: Resultsmentioning

confidence: 99%

“…The average sample size of these 44 studies was 119.3 neonates (range 22–585). Considering the assay used for the measurement of cord leptin, 35 studies employed radioimmunoassay (RIA), 21–24,28–31,34–43,46–61,63 while seven studies used ELISA 20,26,27,32,33,44,62 and two others used a two‐site immunoradiometric assay (IRMA) 25,45 . In six studies, 21,35,38,50,52,63 log leptin was used for the estimation of the level of association; these studies were analysed separately.…”

Section: Resultsmentioning

confidence: 99%

“…The definitions of SGA, AGA, and LGA were based on standard growth curves used in the area or institution of each study. Additionally, gender differences in the correlation values were assessed only in four studies, which calculated separate correlation coefficients for male and female neonates 36,40,48,55 . No study reported results by mode of delivery (vaginal or caesarean), thus a separate analysis could not be performed.…”

Section: Resultsmentioning

confidence: 99%

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Leptin levels in cord blood and anthropometric measures at birth: a systematic review and meta‐analysis

Karakosta¹,

Chatzi²,

Plana

et al. 2010

Paediatric Perinatal Epid

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The role of intrauterine environment in the development of obesity is increasingly recognised. Adipokines and specifically leptin have been examined as potential biomarkers predicting early development of obesity. We conducted a systematic review and meta-analysis of the epidemiological evidence for the association between leptin levels in cord blood and anthropometric measurements at birth in healthy mother-newborn pairs. A PubMed search was performed between 1994 and 2009 and manual search of reference lists of retrieved articles. Forty-four studies met the inclusion criteria set. All studies reported a positive correlation between leptin levels and birthweight. The combined correlation coefficient (r) was 0.46 [95%CI 0.43, 0.50]. Leptin levels explained 21% of variation in birthweight. Results were similar in males (r=0.55; 0.40, 0.68) and females (r=0.60; 0.50, 0.69), and between Caucasians (r=0.45; 0.39, 0.51) and eastern Asian populations (r=0.47; 0.37, 0.55). Statistically significant positive correlations were also found for birth length (r=0.29; 0.23, 0.34) and ponderal index (r=0.36; 0.31, 0.41). There was no indication of publication bias (Egger's test P-value=0.23). This meta-analysis shows a clear but moderate correlation between leptin levels in cord blood and birthweight that is observed in different population groups.

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Maternal Serum Leptin Concentrations Do Not Correlate With Cord Blood Leptin Concentrations in Normal Pregnancy

Abstract: There was no correlation between maternal and cord leptin, which supports the hypothesis of a noncommunicating, two-compartment model of fetoplacental leptin regulation.

Cited by 19 publications

References 25 publications

The Relationship between Birth Weight Leptin and Bone Mineral Status in Newborn Infants

The Relationship between Birth Weight Leptin and Bone Mineral Status in Newborn Infants

Effect of reducing the n‐6/n‐3 fatty acid ratio on the maternal and fetal leptin axis in relation to infant body composition

Leptin levels in cord blood and anthropometric measures at birth: a systematic review and meta‐analysis

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