Maternal serum IL-22 concentrations are significantly upregulated in patients with preterm premature rupture of membranes

Behram, Mustafa; Oğlak, Süleyman Cemil; Başkıran, Yusuf; Çaypınar, Sema Süzen; Akgöl, Sedat; Tunç, Şeyhmus; Özköse, Zeynep Gedik; Akay, Emrullah; Dağ, İsmail

doi:10.5603/gp.a2021.0036

Cited by 14 publications

(14 citation statements)

References 29 publications

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“…Inflammation‐oxidative stress axis acts a crucial role in the pathogenesis of diverse obstetric complications, including PPROM 16,27–30 . The prognostic value of systemic inflammatory markers, including NLR and PLR, in many diseases, such as early pregnancy loss, membrane rupture, and HCA, has already been demonstrated in several studies 19,31,32 .…”

Section: Discussionmentioning

confidence: 99%

“…4,8,13 We diagnosed the clinical chorioamnionitis by the presence of maternal fever (≥38 C orally) with no evidence of an extrauterine cause associated with at least two of the following signs: maternal tachycardia (>100 beats/min), fetal tachycardia (>160 beats/min), leukocytosis, uterine tenderness, abdominal pain, and new-onset purulent foul-smelling vaginal discharge. 14,16 Placental abruption was defined as the partial or complete placenta detachment from the underlying myometrium before the expected delivery time and mainly diagnosed based on clinical grounds in a patient experiencing a new onset of antepartum hemorrhage and painful uterine contractions or uterine tenderness, fetal distress or death, and blood clots behind the placenta. 15,17 In some patients, the diagnosis of placental abruption was made by the detection of the retroplacental hematoma on US examination.…”

Section: Methodsmentioning

confidence: 99%

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Maternal and neonatal outcomes of expectantly managed pregnancies with previable preterm premature rupture of membranes

Can

Oğlak

Ölmez

2022

J of Obstet and Gynaecol

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Purpose: This study aimed to describe the maternal and fetal outcomes associated with expectant management following previable preterm premature rupture of membranes (PPROM) before 24 weeks of gestation. We also analyzed the risk estimates of potential confounders to clarify whether these variables are contributed to the risk of postnatal mortality among these neonates. Methods: This retrospective cohort study included all pregnant patients who experienced previable PPROM before 24 weeks of gestation at a tertiary maternal-fetal medicine center. We used the neonatal data from birth until discharge. Results: A total of 128 women were enrolled. The survival to discharge rate was 60.9%. The median latency period (80 vs. 20 days, respectively, p < 0.001) was significantly longer, the median gestational week at delivery (34 vs. 25 weeks, respectively, p < 0.001) and median birth weight (2100 vs. 710 g, p < 0.001) was significantly higher in the survivor group than the non-survivor group. Surviving neonates had significantly lower frequencies of anhydramnios at any time during the latency period than the non-survivor neonates (38.4% vs. 86.0%, respectively, p < 0.001). Conclusion:This study demonstrated an opposite correlation between the duration of latency period and gestational age at PPROM with earlier membrane rupture in pregnancies having a longer latency period, which additionally clarifies the higher gestational age at delivery. The antepartum factors that increased the possibility of postnatal mortality within our study included the gestational week at delivery, duration of the latency period, anhydramnios at any time during the latency period, and birth weight.

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Maternal and neonatal outcomes of expectantly managed pregnancies with previable preterm premature rupture of membranes

Can

Oğlak

Ölmez

2022

J of Obstet and Gynaecol

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“… 22 PTB was defined as a delivery at <37 weeks of gestation. 23 According to birth weight, newborns were divided into LBW (<2500 g), normal birth weight (2500–4000 g), and macrosomia (>4000 g). 24 , 25 Based on a reported reference curve, SGA and LGA referred to neonates whose birth weights were less than the 10th and more than the 90th percentile by gestational age, respectively.…”

Section: Methodsmentioning

confidence: 99%

Association of Maternal Serum Uric Acid and Cystatin C Levels in Late Pregnancy with Adverse Birth Outcomes: An Observational Cohort Study in China

Yuan¹,

Han²,

Jia³

et al. 2022

IJWH

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Objective To investigate the associations between serum uric acid (UA) and cystatin C (CysC) levels in late pregnancy with major unfavorable birth outcomes. Methods We retrospectively analyzed the maternal UA and CysC levels during late pregnancy and their relationship with unfavorable birth outcomes in a Chinese population (n = 11,580). Results Women with the highest quartile of UA had higher risks of low birth weight (LBW) and small for gestational age (SGA) babies and a lower risk of preterm birth (PTB) compared to women with the lowest quartile [for LBW, adjusted-odds ratio (OR) = 2.63, 95% CI: 1.76, 3.95; for SGA, adjusted-OR = 2.11, 95% CI: 1.73, 2.57; for PTB, adjusted-OR = 0.55, 95% CI: 0.45, 0.69; all P for trend <0.001]. Compared to women in the lowest quartile of CysC, higher risks of macrosomia and large for gestational age (LGA) and lower risks of PTB and SGA were observed for those in the highest quartile (for macrosomia, adjusted-OR = 2.01, 95% CI: 1.60, 2.51; for LGA, adjusted-OR = 1.97, 95% CI: 1.67, 2.32; for PTB, adjusted-OR = 0.32, 95% CI: 0.26, 0.41; all P for trend <0.001; for SGA, adjusted-OR = 0.78, 95% CI: 0.64, 0.96; P for trend <0.05). Conclusion This study reports the associations of maternal UA and CysC with adverse birth outcomes, and suggests that routine determination of maternal UA and CysC in late pregnancy is beneficial for assessing the risks of these outcomes.

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“…PPROM was described as a rupture of the fetal membranes before 37 weeks of completed gestation. [14] ICP was diagnosed by the association of pruritus and bile acids ≥10 μmol/L (after other reasons of liver dysfunction and itching were ruled out) and by normalization of the levels of serum bile acids after birth. [15] Placenta previa was described as the condition where the abnormal implantation of placental tissue overlying the endocervical os.…”

Section: Methodsmentioning

confidence: 99%

The implications for advanced maternal age on pregnancy complications and adverse neonatal outcomes

Özköse¹,

Oğlak²

2021

Perinatal J

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Objective This study aimed to determine the effect of advanced maternal age (AMA) on maternal and neonatal outcomes in pregnant women aged ≥35 years compared with patients aged 30–34 years. Also, we aimed to analyze the risk estimates of potential confounders to identify whether these variables contributed to the development of adverse pregnancy outcomes or not. Methods This retrospective cohort study included 2284 pregnant women aged ≥35 years at the time of delivery who was delivered in a tertiary referral hospital from January 1, 2016, to December 31, 2020. We further classified these women into two subgroups: 35–39 years as early AMA (EAMA), and ≥40 years as very AMA (VAMA). Pregnancy complications and adverse neonatal outcomes were recorded. Results Compared to younger women, pregnant AMA women had significantly higher risks of complicated pregnancies, including a higher risk of gestational diabetes mellitus (GDM, p<0.001), polyhydramnios (p<0.001), cesarean section (p<0.001), stillbirths (p<0.001), major fetal abnormality (p<0.001), preterm delivery (p<0.001), lower birth weight (p<0.001), lower 5-minute Apgar scores (p<0.001), lower umbilical artery blood pH values (p<0.001), neonatal intensive care unit (NICU) admission (p<0.001), and length of NICU stay (p<0.001). Conclusion We found a strong and significant association between VAMA and adverse pregnancy outcomes, including an increased risk of GDM, polyhydramnios, cesarean section, and adverse neonatal outcomes, including a higher risk of stillbirths, preterm delivery, lower birth weight, lower 5-minute Apgar scores, and NICU admission.

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Maternal serum IL-22 concentrations are significantly upregulated in patients with preterm premature rupture of membranes

Cited by 14 publications

References 29 publications

Maternal and neonatal outcomes of expectantly managed pregnancies with previable preterm premature rupture of membranes

Maternal and neonatal outcomes of expectantly managed pregnancies with previable preterm premature rupture of membranes

Association of Maternal Serum Uric Acid and Cystatin C Levels in Late Pregnancy with Adverse Birth Outcomes: An Observational Cohort Study in China

The implications for advanced maternal age on pregnancy complications and adverse neonatal outcomes

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