Maternal serum and fetal cord blood concentrations of thiol/disulfide and ischemia-modified albumin as predictors of neural tube defects

Öcal, Özgür; Öcal, Fatma Doğa; Sınacı, Selcan; Daglar, Zeynep; Secen, Ahmet Eren; Oğuz, Esra Fırat; Erel, Özcan; Tayman, Cüneyt; Şahın, Dilek; Belen, Ahmet Deniz; Dalgıç, Ali

doi:10.5137/1019-5149.jtn.40096-22.3

Cited by 2 publications

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“…Renal biopsy was performed in two patients showing IgA deposition in the glomeruli. The most common treatment strategies are steroids and steroid combined immunosuppressants, with a mean treatment duration of 8 months (5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16). The mean and median glucocorticoid (GC) dose was 3.9 g (0-18 g) and 7, respectively.…”

Section: Resultsmentioning

confidence: 99%

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Evaluation of adult immunoglobulin A vasculitis with oxidative stress and inflammation biomarkers

Balik,

Omma

et al. 2023

Med-Science

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IgA vasculitis (IgAV) is a leukocytoclastic vasculitis affecting small vessels and is more common in children than in adults. In this study, we aimed to investigate the effects of oxidative stress in adult IgAV patients by Dynamic Thiol Disulfide Homeostasis (DTDH) and Ischemia Modified Albumin (IMA) levels. We also aimed to correlate the presence of inflammation detected by C-Reactive Protein (CRP) and Highly Sensitive C-Reactive Protein (hsCRP) with these oxidative stress parameters. Forty-one IgAV patients and forty-five controls were included in the study. Patients were classified as "active" or "in remission" according to the British Vasculitis Activity Score (BVAS). Measured parameters were compared between the groups. DTDH, IMA, CRP and hsCRP parameters were analyzed in both patient and control groups. According to our results, disulfide (p=0.047), index 1 (p<0.001), index 2 (p<0.001), IMA (p<0.001), CRP (p=0.005) and hsCRP (p=0.004) levels were significantly increased while native thiol (p<0.001), total thiol (p<0.001) and index 3 (p<0.001) levels were significantly decreased in IgAV patients. The results of this study show that oxidative stress is associated with IgAV disease and also with disease severity. The oxidative stress parameters evaluated were also correlated with markers of inflammation.

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Section: Resultsmentioning

confidence: 99%

“…IMA is considered as a biomarker of oxidative stress, inflammation and vascular endothelial dysfunction [14]. The relationships between various diseases and DTDH vith IMA impairments have been shown up to date [15][16][17].…”

Section: Discussionmentioning

confidence: 99%

Evaluation of adult immunoglobulin A vasculitis with oxidative stress and inflammation biomarkers

Balik,

Omma

et al. 2023

Med-Science

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“… 58 Maternal diabetes delays neural differentiation in the developing neuroepithelium, leading to NTD formation. 58 , 59 Therefore, we used this in vitro model, P19 cells, to investigate how GH influences embryonic stem cell differentiation into neural lineage cells. We used glucose at varying concentrations together with RA to study how glucose levels affect neural differentiation.…”

Section: Discussionmentioning

confidence: 99%

High glucose inhibits neural differentiation by excessive autophagy <em>via</em> peroxisome proliferator-activated receptor gamma

et al. 2023

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The high prevalence of prediabetes and diabetes globally has led to the widespread occurrence of severe complications, such as diabetic neuropathy, which is a result of chronic hyperglycemia. Studies have demonstrated that maternal diabetes can lead to neural tube defects by suppressing neurogenesis during neuroepithelium development. While aberrant autophagy has been associated with abnormal neuronal differentiation, the mechanism by which high glucose suppresses neural differentiation in stem cells remains unclear. Therefore, we developed a neuronal cell differentiation model of retinoic acid induced P19 cells to investigate the impact of high glucose on neuronal differentiation in vitro. Our findings indicate that high glucose (HG) hinders neuronal differentiation and triggers excessive. Furthermore, HG treatment significantly reduces the expression of markers for neurons (Tuj1) and glia (GFAP), while enhancing autophagic activity mediated by peroxisome proliferator-activated receptor gamma (PPARγ). By manipulating PPARγ activity through pharmacological approaches and genetically knocking it down using shRNA, we discovered that altering PPARγ activity affects the differentiation of neural stem cells exposed to HG. Our study reveals that PPARγ acts as a downstream mediator in high glucose-suppressed neural stem cell differentiation and that refining autophagic activity via PPARγ at an appropriate level could improve neuronal differentiation efficiency. Our data provide novel insights and potential therapeutic targets for the clinical management of gestational diabetes mellitus.

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Maternal serum and fetal cord blood concentrations of thiol/disulfide and ischemia-modified albumin as predictors of neural tube defects

Cited by 2 publications

References 0 publications

Evaluation of adult immunoglobulin A vasculitis with oxidative stress and inflammation biomarkers

Evaluation of adult immunoglobulin A vasculitis with oxidative stress and inflammation biomarkers

High glucose inhibits neural differentiation by excessive autophagy <em>via</em> peroxisome proliferator-activated receptor gamma

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