Maternal separation on the ethanol-preferring adult rat liver structure

Abstract

There is interaction of MS and EtOH on the liver structure, dependent on the amount of EtOH intake. Furthermore, the interaction of stress and drugs can increase or decrease their effects on the liver or indirectly via hypothalamic-pituitary-adrenal (HPA) and hypothalamic-pituitary-gonadal (HPG) axes.

Neonatal corticosterone administration increases p27-positive Sertoli cell number and decreases Sertoli cell number in the testes of mice at prepuberty

“…This study demonstrated that CORT administration increased the p27-positive Sertoli cell number and decreased Sertoli cell number on PNDs 10 and 16 (Figs. 5,6,7,8,9,10). These results suggest that CORT induced following maternal separation is one of the triggers for the decreased Sertoli cell number in the testes of NMS mice.…”

“…They are secreted following exposure to stress and assist humans and animals cope with several stressful situations 3 . Notably, several studies have demonstrated that excessive secretion of CORT following exposure to extreme mental or physical stresses in early life stages, i.e., early life stress (ELS), has adverse effects on the health of humans and animals in later life [4][5][6][7][8][9][10][11] . In addition, it has been reported that glucocorticoid administration during early life stages causes a decrease in brain weight, reduction in myelination of fibers, persistent downregulation of glucocorticoid receptors (GRs), impairment of adrenocortical response to stress, learning disturbance, developmental delay, change in HPA reactivity, and increase in depressive-like behavior [12][13][14][15][16][17][18][19][20][21] .…”