Maternal risk factors for retinopathy of prematurity – a population‐based study

Holmström, Gerd; Thomassen, P.; Broberger, U.

doi:10.3109/00016349609054687

Cited by 43 publications

(44 citation statements)

References 31 publications

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“…Risk factors for ROP were also studied and a detailed analysis of maternal data from antenatal centres and labour rooms was recently published (Holmströ m et al 1996). An association of ROP with essential hypertension before pregnancy was found.…”

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confidence: 99%

Neonatal risk factors for retinopathy of prematurity ‐ a population‐based study

Holmström

Broberger

Thomassen

1998

Acta Ophthalmologica Scandinavica

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ABSTRACT.Purpose: The aim of the study was to evaluate possible neonatal risk factors for retinopathy of prematurity (ROP) in a population-based group of preterm, very low birth weight, infants. Method: The main study group included 202 single-born infants with a birth weight of 1500 grams or less. A group of 57 twins were also described. Selected risk factors were extracted from the neonatal records. Results: Univariate analysis revealed an association between ROP and respiratory distress syndrome (RDS), bronchopulmonary dysplasia (BPD), septicaemia, intraventricular bleeding, and the use of ventilator as well as continuous positive airway pressure. In a stepwise logistic regression analysis, however, only gestational age at birth, birth weight and BPD were significantly associated with ROP. Conclusion: Prematurity per se remains the strongest risk factor for ROP.Key words: retinopathy of prematurity -risk factors -gestational age -birth weight -bronchopulmonary dysplasia.

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confidence: 99%

Neonatal risk factors for retinopathy of prematurity ‐ a population‐based study

Holmström

Broberger

Thomassen

1998

Acta Ophthalmologica Scandinavica

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“…None of the maternal risk factors reported were associated with ROP or its severe form, a finding which is consistent with other studies. 9,12 Our study showed a success rate of 93.7% using cryotherapy, which used to be the standard treatment of retinopathy of prematurity. The current standard is laser treatment, which has been used in different trials with a high success rate, although many centers lack the facilities to use this and so rely on cryotherapy.…”

Section: Discussionmentioning

confidence: 60%

“…Low birth weight is constantly associated with the disease, as, to a lesser extent, is oxygen therapy. 3,5,[11][12][13][15][16][17][18][19][20][21][22]26 Regression of the disease without treatment occurs in the majority of preterm babies who have the disease. However, the threshold stage of ROP is the severe form of the disease, and the recommended treatment is either cryotherapy or laser treatment.…”

Section: Discussionmentioning

confidence: 99%

“…1,2,4,5 Since many premature and extremely low birth weight babies survive, the disease has become a challenge to neonatologists and ophthalmologists. The incidence varies in different neonatal units, 3,[6][7][8][9][10][11][12][13] and low birth weight has been the only risk factor uniformly identified. 1,3,4,[6][7][8][9][10][11][13][14][15][16][17] The rate of the threshold form of the disease has been measured in different neonatal units, 6,7,9,13 however, its association with risk factors has not been fully identified.…”

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confidence: 99%

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Threshold Stage of Retinopathy of Prematurity: Maternal and Neonatal Risk Factors

Al-Essa

Azad

Rashwan³

2000

Ann Saudi Med

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Background:The aim of this study was to review the maternal and neonatal risk factors associated with retinopathy of prematurity (ROP) and the threshold stage of the disease. Patients and Methods: In this prospective cohort study, all preterm infants of less than 1501 g birth weight were screened for ROP between January 1996 and December 1997 at the neonatal unit of the Maternity Hospital in Kuwait. The rate of the threshold stage of ROP, as well as risk factors associated with the disease, were identified. Results: A total of 234 babies were screened for ROP, of which 151 (64.5%) developed the disease and 34 (14.5%) had the threshold stage of ROP. Several factors were found to be associated with ROP and threshold ROP. Stepwise regression analysis revealed that low birth weight (P<0.002) and exposure to high oxygen concentration (P<0.0001) were independently associated with ROP. In addition, low birth weight (P<0.006), high oxygen concentration (P<0.003), and culture-proven sepsis (P<0.04) were found to be independent predictors of threshold ROP. Conclusion: Apart from low birth weight and exposure to high oxygen therapy, which are well-documented risk factors of ROP, septicemia was also found to be associated with the threshold stage of ROP.

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“…The incidence varies in different neonatal units (5)(6)(7) and low birth weight has been the only risk factor uniformly identified (5)(6)(7)(8)(9)(10)(11)(12)(13)(14). However, the disease may occur in the larger birth weight babies but with no information about the prognosis and the risk factors associated with it (10,15).…”

Section: Introductionmentioning

confidence: 99%

Retinopathy of prematurity in infants with birth weight above 1500 grams

Al-Essa

Rashwan²,

Alajmi³

2009

E Af Med Jrnl

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Objective: To identify the rate and prognosis of retinopathy of prematurity (ROP) among newborn infants of birthweight of above 1500 grams, and the possible risk factors associated with the disease. Design: A prospective cohort study. Setting: Neonatal unit at Maternity Hospital, Kuwait city, Kuwait. Methods: All low birth weight infants were examined for the presence of ROP in the period between January 1996 to December 1997. Prospective collection of data on babies who were above 1500 grams was done to find an association between the disease in these babies and some of the maternal and neonatal risk factors. Results: A total of 68 babies of birth weight above 1500 grams were screened for ROP out of which 13 (19.1%) had different stages of the disease. None of the patients had threshold disease requiring surgery. Among the risk factors chosen, oxygen therapy, presence of hypotension at birth and the non-use of surfactant were the only risk factors to be associated with disease. However, with logistic regression analysis, none of these were independently associated with ROP. Conclusion: ROP may occur in newborn infants of larger birthweight but with good prognosis, and oxygen therapy seems to predispose to the disease.

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Maternal risk factors for retinopathy of prematurity – a population‐based study

Abstract: Prematurity per se remains the strongest risk factor for ROP.

Cited by 43 publications

References 31 publications

Neonatal risk factors for retinopathy of prematurity ‐ a population‐based study

Neonatal risk factors for retinopathy of prematurity ‐ a population‐based study

Threshold Stage of Retinopathy of Prematurity: Maternal and Neonatal Risk Factors

Retinopathy of prematurity in infants with birth weight above 1500 grams

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