Neonatal risk factors for retinopathy of prematurity ‐ a population‐based study

Abstract

ABSTRACT.Purpose: The aim of the study was to evaluate possible neonatal risk factors for retinopathy of prematurity (ROP) in a population-based group of preterm, very low birth weight, infants. Method: The main study group included 202 single-born infants with a birth weight of 1500 grams or less. A group of 57 twins were also described. Selected risk factors were extracted from the neonatal records. Results: Univariate analysis revealed an association between ROP and respiratory distress syndrome (RDS), bronchopulmonary dysplasia (BPD), septicaemia, intraventricular bleeding, and the use of ventilator as well as continuous positive airway pressure. In a stepwise logistic regression analysis, however, only gestational age at birth, birth weight and BPD were significantly associated with ROP. Conclusion: Prematurity per se remains the strongest risk factor for ROP.Key words: retinopathy of prematurity -risk factors -gestational age -birth weight -bronchopulmonary dysplasia.

Is being small for gestational age a risk factor for retinopathy of prematurity? A study with 345 very low birth weight preterm infants

“…A ROP afeta mais frequentemente os pré-termo de menor idade gestacional (IG), mesmo aqueles com poucas comorbidades, mas ocorre, também, em bebês maiores, porém mais doentes [4][5][6] .…”

“…Esse achado, que tem sido mais recentemente relatado [6][7][8][9] , já havia sido divulgado nos estudos de Johnson et al, em 1978 10 , e de Distefano et al, em 1993 11 , quando foi descrita uma associação entre bebês nascidos PIG e a ROP.…”

The Effect of Anemia on Retinopathy of Prematurity in Extremely Low Birth Weight Infants

“…6 Numerous retrospective studies have examined potential risk factors contributing to development of ROP. These have included low gestational age at birth, 7 ± 12 low birth weight, 5,10,12 ± 14 male sex, 9 white race, 12,15 bronchopulmonary dysplasia, 5,10,13,16 sepsis, 8,13 acidosis, 7,11,16 oxygen therapy, 14,17 hyperoxia, 2,11,18 hypocarbia, 19 hypoxia, 1,11,19 and maternal use of beta blockers immediately before birth. 14 Recently, a case of neonatal HIV infection after blood transfusion at another institution led to a decrease in blood transfusions in premature infants at that hospital.…”

Prematüre Retinopatisinde Klinik Seyir, Tedavinin Değerlendirilmesi ve İlişkili Risk Faktörlerinin Belirlenmesi

“…Holmstrom 24 düflük do¤um a¤›rl›¤› ve düflük gestasyon yafl› d›fl›nda bronkopulmoner displazinin prematüre retinopatisi gelfliminde etkili oldu¤unu bildirmifl ayr›ca maternal risk faktörlerini de¤erlendirmifl ve gebelik öncesinde esansiyel hipertansiyon varl›¤›n›n belirleyici risk faktörü oldu¤unu belirtmifltir 25 . Klini¤imizdeki çal›flmada düflük do¤um a¤›rl›¤›, düflük gestasyon yafl›, mekanik ventilatör tedavisi ve ço¤ul gebeli¤in prematüre retinopatisi gelifliminde etkili risk faktörleri oldu¤u görülmüfltür.…”