Maternal recurrent pregnancy loss is associated with an increased risk for long‐term neurological morbidity in offspring

Levy, Dorit Paz; Wainstock, Tamar; Sergienko, Ruslan; Landau, Daniella; Walfisch, Asnat

doi:10.1111/dmcn.13976

Cited by 14 publications

(8 citation statements)

References 37 publications

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“…History of miscarriage is associated with increased risk of NDD offspring, as stated in different studies (Paz Levy et al, 2019). In contrast with these findings, our result showed a lower maternal rate of abortion or miscarriage as the risk of giving birth of NDD offspring with an odds ratio of 3.13 (95% CI 1.37-7.17).…”

Section: Discussioncontrasting

confidence: 90%

Mother’s Adverse Childhood Experiences and Elevated Risk of Neuro-developmental Disorders in Offspring: a Case–Control Study

et al. 2021

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This case-control study estimated the association between maternal adverse childhood experience (ACE) and neurodevelopmental disorders (NDD) in offspring. The study included 122 mothers with NDD children as case and 234 mothers with healthy children as control from 3 urban sub-districts of Dhaka, Bangladesh. Respondents' socio-demographic variables and ACE history were collected. A multivariate regression model was used to examine the association. Mothers with a history of more than 3 ACE are fourfold more vulnerable to give birth to NDD offspring than mothers having 3 or less ACE after adjusting with other covariates. The findings implicate the importance of routine screening of pregnant women for ACE to minimize the risk of giving birth to NDD offspring and taking effective measures to protect children from all types of violence in line with the UN convention on the rights of the child.

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Section: Discussioncontrasting

confidence: 90%

Mother’s Adverse Childhood Experiences and Elevated Risk of Neuro-developmental Disorders in Offspring: a Case–Control Study

et al. 2021

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“…[1]. RSA is defined as two or more successive abortions before 20 weeks from the last menstruation [2]. The possible causes for RSA include parental chromosomal abnormalities, untreated hypothyroidism, uncontrolled diabetes mellitus, certain uterine anatomic abnormalities and antiphospholipid antibody syndrome (APS).…”

Section: Introductionmentioning

confidence: 99%

Association of spontaneous abortion and Ureaplasma parvum detected in placental tissue

Oliveira

et al. 2020

Epidemiol. Infect.

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Abstract Spontaneous abortion is considered a public health problem having several causes, including infections. Among the infectious agents, bacteria of the vaginal microbiota and Ureaplasma parvum have been associated with abortion, but their participation needs to be further elucidated. This study aims to evaluate the influence of Mollicutes on the development of spontaneous abortion. Women who underwent spontaneous abortion and those with normal birth (control) were studied. Samples of cervical mucus (CM) and placental tissue were collected to identify Mollicutes using the quantitative polymerase chain reaction methodology. Eighty-nine women who had a miscarriage and 20 women with normal pregnancies were studied. The presence of Mollicutes in placental tissue increased the chance of developing miscarriage sevenfold. The prevalence of U. parvum in women who experienced spontaneous abortion was 66.3% in placental tissue. A positive association was observed between the detection of U. parvum in samples of placental tissue and abortion. There was a significant increase in microbial load in placental tissue for M. hominis, U. urealyticum and U. parvum compared to the control group. Detection of U. parvum in CM in pregnant women can ascend to the region of the placental tissue and trigger a spontaneous abortion.

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“…Recently, a growing body of evidence demonstrated the association between RPL and long‐term morbidity of the offspring. Offspring of mothers with RPL were found to have a higher risk of long‐term gastrointestinal 15 and neurological 16 morbidities.…”

Section: Introductionmentioning

confidence: 99%

“…Offspring of mothers with RPL were found to have a higher risk of long-term gastrointestinal 15 and neurological 16 morbidities.…”

mentioning

confidence: 99%

Maternal history of recurrent pregnancy loss and future risk of ophthalmic morbidity in the offspring

Aharon

Wainstock

Tsumi

et al. 2020

American J Rep Immunol

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Objective The objective of the study was to investigate whether maternal history of recurrent pregnancy loss (RPL) is associated with offspring childhood ophthalmic morbidity. Method A hospital‐based cohort analysis comparing long‐term offspring ophthalmic morbidity in women with and without a history of RPL was performed. Ophthalmic morbidity included hospitalizations involving a pre‐defined set of ICD‐9 codes. Offspring with congenital anomalies, perinatal mortality cases, and multifetal pregnancies were excluded from the analysis. Cumulative morbidity incidence was compared using Kaplan‐Meier survival curves, and the risk of long‐term ophthalmic morbidity was assessed by Cox proportional hazards model after adjustment for confounders. Results During the study period, 242,187 newborns met the inclusion criteria; 5% (12,182) of them were offspring born to mothers with a history of RPL. Ophthalmic morbidity was significantly more common in the RPL group (1.3% vs 0.9%, p < .001, Kaplan‐Meier log‐rank p < .001). Adjustment for confounders, such as maternal age, gestational age, hypertensive disorders, and maternal diabetes, using Cox regression found that being born to a mother with RPL was independently associated with long‐term ophthalmic morbidity (adjusted HR 1.35, 95% CI 1.15‐1.59, p < .001). Conclusion Being born to a mother with RPL is independently associated with an increased risk of ophthalmic morbidity.

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Maternal recurrent pregnancy loss is associated with an increased risk for long‐term neurological morbidity in offspring

Abstract: Hospitalizations for epilepsy and developmental disorders are significantly more common among children of mothers with a history of recurrent pregnancy loss.

Cited by 14 publications

References 37 publications

Mother’s Adverse Childhood Experiences and Elevated Risk of Neuro-developmental Disorders in Offspring: a Case–Control Study

Mother’s Adverse Childhood Experiences and Elevated Risk of Neuro-developmental Disorders in Offspring: a Case–Control Study

Association of spontaneous abortion and Ureaplasma parvum detected in placental tissue

Maternal history of recurrent pregnancy loss and future risk of ophthalmic morbidity in the offspring

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