Association of spontaneous abortion and <i>Ureaplasma parvum</i> detected in placental tissue

Oliveira, Caline Novais Teixeira; Oliveira, Maria Tânia Silva; Oliveira, Hellenn Cardoso; Silva, L S C; Freire, Raquel Sousa; Júnior, Manoel Neres Santos; Timenetsky, Jorge; Campos, Guilherme Barreto; Marques, Lucas Miranda

doi:10.1017/s0950268820001302

Cited by 12 publications

(13 citation statements)

References 32 publications

(47 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…were also detected by next-generation sequencing (in a study that also used PCR and culture for detection) as the most prevalent uterine colonizer in pregnant women with and without chorioamnionitis, specifically, individuals in premature births with severe chorioamnionitis had high abundance of U. parvum ( 96 ). There is also a positive association between the detection of U. parvum in samples of placental tissue and abortion ( 97 ). Therefore, these studies suggest that ureaplasmas that infects humans or animals can colonize/infect the placenta and amniotic fluid for long periods during pregnancy in the absence or presence of adverse outcomes.…”

Section: Ureaplasma Diversummentioning

confidence: 99%

A Review of Ureaplasma diversum: A Representative of the Mollicute Class Associated With Reproductive and Respiratory Disorders in Cattle

et al. 2021

View full text Add to dashboard Cite

The Mollicutes class encompasses wall-less microbes with a reduced genome. They may infect plants, insects, humans, and animals including those on farms and in livestock. Ureaplasma diversum is a mollicute associated with decreased reproduction mainly in the conception rate in cattle, as well as weight loss and decreased quality in milk production. Therefore, U. diversum infection contributes to important economic losses, mainly in large cattle-producing countries such as the United States, China, Brazil, and India. The characteristics of Mollicutes, virulence, and pathogenic variations make it difficult to control their infections. Genomic analysis, prevalence studies, and immunomodulation assays help better understand the pathogenesis of bovine ureaplasma. Here we present the main features of transmission, virulence, immune response, and pathogenesis of U. diversum in bovines.

show abstract

Section: Ureaplasma Diversummentioning

confidence: 99%

A Review of Ureaplasma diversum: A Representative of the Mollicute Class Associated With Reproductive and Respiratory Disorders in Cattle

et al. 2021

View full text Add to dashboard Cite

show abstract

“…Detection of Mollicutes in the placenta was associated with miscarriage and there was also a significant increase in microbial load of M. hominis, U. urealyticum and U. parvum in miscarriage patients compared to the control group. While the authors proposed that this represented ascending infection of placental tissue leading to the adverse event, the presence of these organisms in cervical swabs suggests possibility of contamination during sample collection [29]. Table 1 gives examples of studies which have explored the relationship between the vaginal microbiota and early pregnancy as well as assisted reproduction.…”

Section: Miscarriagementioning

confidence: 99%

The reproductive tract microbiota in pregnancy

2021

View full text Add to dashboard Cite

The reproductive tract microbiota plays a crucial role in maintenance of normal pregnancy and influences reproductive outcomes. Microbe-host interactions in pregnancy remain poorly understood and their role in shaping immune modulation is still being uncovered. In this review we describe the composition of vaginal microbial communities in the reproductive tract and their association with reproductive outcomes. We also consider strategies for manipulating microbiota composition by using live biotherapeutics, selective eradication of pathogenic bacteria with antibiotics and vaginal microbiota transplantation. Finally, future developments in this field and the need for mechanistic studies to explore the functional significance of reproductive tract microbial communities are highlighted.

show abstract

“…It has been proven that vaginal infections may negatively affect pregnancy, leading to complications such as spontaneous abortion, premature rupture of membranes (PROM), preterm delivery, intrauterine growth restriction, intrauterine death, neonatal infections and postpartum infections (1)(2)(3)(4)(5)(6)(7). Genital tract infections in pregnancy account for ~15% of first trimester miscarriages and 66% of late miscarriages (8,9). In addition, the implication of infection in the etiology of recurrent loss remains unclear, with an incidence of 0.5-5% (8,10).…”

Section: Introductionmentioning

confidence: 99%

“…Genital tract infections in pregnancy account for ~15% of first trimester miscarriages and 66% of late miscarriages ( 8 , 9 ). In addition, the implication of infection in the etiology of recurrent loss remains unclear, with an incidence of 0.5-5% ( 8 , 10 ).…”

Section: Introductionmentioning

confidence: 99%

“…According to the pathogenesis, the evasion of the local immune response has been suggested. Endometrial immunity is activated by bacterial infections and an intense immune response follows, affecting the beginning of a pregnancy ( 2 , 8 ). Further evidence recently emerged in favor of the association between U. urealyticum , alone or in combination with M. hominis and obstetrical pregnancy complications, including premature rupture of membranes, preterm delivery and abortion ( 17 ).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Genital infection with Ureaplasma urealyticum and its effect on pregnancy

et al. 2021

View full text Add to dashboard Cite

Chorioamnionitis or intra-amniotic infection is an infection that affects the intrauterine content during pregnancy. Numerous studies have reported vaginal colonization with various types of infectious agents as a risk factor for chorioamnionitis. Although this complication occurs due to the ascending polymicrobial bacterial infection at the time of membrane breakage, it may also occur in pregnant women with intact membranes, mainly due to Ureaplasma urealyticum (U. urealyticum) and Mycoplasma hominis (M. hominis). The main aim of the present study was to identify a region-specific panel of infectious agents that can be used more accurately determine premature birth, as well as the premature rupture of membranes (PROM). Thus, a 10-year retrospective study was conducted. A total of 1,301 pregnant women with PROM and premature birth or spontaneous abortion were included in the study. It was observed that the main infectious agent varied in the five groups analyzed in total. The infectious agent distribution also varied depending on environmental parameters. Ureaplasma was found to be the most frequently detected germ amongst the infectious agents of the vaginal cultures from pregnant women enrolled in the present study, regardless of gestational age. On the whole, the findings of the present study suggest that additional studies are required, in order to confirm that diagnosis and treatment according to laboratory results of vaginal infections with U. urealyticum/M. hominis during the first trimester of pregnancy could prevent premature birth, abortion or chorioamnionitis.

show abstract

Association of spontaneous abortion and Ureaplasma parvum detected in placental tissue

Cited by 12 publications

References 32 publications

A Review of Ureaplasma diversum: A Representative of the Mollicute Class Associated With Reproductive and Respiratory Disorders in Cattle

A Review of Ureaplasma diversum: A Representative of the Mollicute Class Associated With Reproductive and Respiratory Disorders in Cattle

The reproductive tract microbiota in pregnancy

Genital infection with Ureaplasma urealyticum and its effect on pregnancy

Contact Info

Product

Resources

About