Maternal RAS influence on the ontogeny of thirst

Perillán, Carmen; Costales, M.; Vijande, M.; Argüelles, Juan

doi:10.1016/j.physbeh.2007.04.031

Cited by 15 publications

(9 citation statements)

References 25 publications

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“…The development of dipsogenic and additional regulatory mechanisms for the control of hydrosaline homeostasis through ingestive behaviour occurs during foetal development and early life and therefore may be susceptible to changes in the uterine environment 43 46 Female reproduction makes significant demands on body fluid control to meet the needs of the foetus in utero and to support lactation after parturition, 47 as can also be observed in our results.…”

Section: Discussionsupporting

confidence: 77%

Offspring’s hydromineral adaptive responses to maternal undernutrition during lactation

Núñez

Argüelles

Perillán

2015

J Dev Orig Health Dis

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Early development, throughout gestation and lactation, represents a period of extreme vulnerability during which susceptibility to later metabolic and cardiovascular injuries increases. Maternal diet is a major determinant of the foetal and newborn developmental environment; maternal undernutrition may result in adaptive responses leading to structural and molecular alterations in various organs and tissues, such as the brain and kidney. New nephron anlages appear in the renal cortex up to postnatal day 4 and the last anlages to be formed develop into functional nephrons by postnatal day 10 in rodents. We used a model of undernutrition in rat dams that were food-restricted during the first half of the lactation period in order to study the long-term effects of maternal diet on renal development, behaviour and neural hydromineral control mechanisms. The study showed that after 40% food restriction in maternal dietary intake, the dipsogenic responses for both water and salt intake were not altered; Fos expression in brain areas investigated involved in hydromineral homeostasis control was always higher in the offspring in response to isoproterenol. This was accompanied by normal plasma osmolality changes and typical renal histology. These results suggest that the mechanisms for the control of hydromineral balance were unaffected in the offspring of these 40% food-restricted mothers. Undernutrition of the pups may not be as drastic as suggested by dams' restriction.

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Section: Discussionsupporting

confidence: 77%

Offspring’s hydromineral adaptive responses to maternal undernutrition during lactation

Núñez

Argüelles

Perillán

2015

J Dev Orig Health Dis

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“…It is thus possible that, for humans, thirst is “hard-wired” to a far higher degree than hunger. Swallowing and fluid ingestion are nonetheless known to develop prenatally in humans and similar species (Ross & Nijland, 1998; Ross, El-Haddad, Desai, Gayle, & Beall, 2003) and there is substantial evidence that the physiological and neural systems involved in thirst and fluid ingestion are also “programmed” prenatally in response to conditions in utero (El-Haddad & Ross, 2006; El-Haddad, Desai, Gayle & Ross, 2004; Mansano, Desai, Garg, Choi & Ross, 2007; Perillan, Costales, Vijande & Arguelles, 2007, in press ). …”

Section: The Development Of Hunger Thirst and Satietymentioning

confidence: 99%

Alimentary epigenetics: A developmental psychobiological systems view of the perception of hunger, thirst and satiety☆

Harshaw

2008

Developmental Review

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Hunger, thirst and satiety have an enormous influence on cognition, behavior and development, yet we often take for granted that they are simply inborn or innate. Converging data and theory from both comparative and human domains, however, supports the conclusion that the phenomena hunger, thirst and satiety are not innate but rather emerge probabilistically as a function of experience during individual development. The metatheoretical perspective provided by developmental psychobiological systems theory provides a useful framework for organizing and synthesizing findings related to the development of the perception of hunger, thirst and satiety, or alimentary interoception. It is argued that neither developmental psychology nor the psychology of eating and drinking have adequately dealt with the ontogeny of alimentary interoception and that a more serious consideration of the species-typical developmental system of food and fluid intake and the many modifications that have been made therein is likely necessary for a full understanding of both alimentary and emotional development.

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“…After this period, pups were then returned to the dam for 1 hour and 45 minutes and reweighed. Finally, relative weight gain during the test period was calculated . According to Wirth and Epstein, who first designed this intake test, the evaporative loss is assumed to be the same for all challenge and control rats, and there is no spontaneous excretion in the suckling rat …”

Section: Methodsmentioning

confidence: 99%

Selenium supplementation during pregnancy and lactation promotes metabolic changes in Wistar rats' offspring

Laureano‐Melo

Império

Kluck³

et al. 2020

Clin Exp Pharma Physio

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Epidemiological and animal studies have demonstrated a strong association between selenium (Se) supplementation and metabolic disorders, we aimed to evaluate whether maternal Se supplementation was able to change metabolic parameters in rats' offspring. Moreover, as Se is a deiodinase (DIO) cofactor, we decided to investigate how thyroid hormones (THs) would be involved in such metabolic changes.Thereby, two groups (n = 6, ~250 g) of female Wistar rats underwent isotonic saline or sodium selenite (1 mg/kg, p.o.) treatments. Although there were no significant differences in body weight between groups, the Se treatment during pregnancy and lactation increased milk intake and the visceral white adipose tissue (WAT) in offspring.The rats whose mothers were treated with Se also presented an improvement in the glucose tolerance test and in the glucose-stimulated insulin secretion. Regarding the lipid metabolism, the Se group had a reduction of triglycerides in the liver and in WAT.These metabolic changes were accompanied by an increase in serum triiodothyronine (T 3 ) and in DIO 2 expression in brown adipose tissue (BAT). We further demonstrate an increased expression of peroxisome proliferator-activated receptor-gamma coactivator 1-alpha (PGC-1α) and nuclear respiratory factor-1 (NRF-1) mRNA in the liver. In adulthood offspring, Se supplementation programs thyroid function, glucose homeostasis, and feeding behaviour. Taken together, there is no indication that Se programming causes insulin resistance. Moreover, we conjecture that these metabolic responses are induced by increased thyroxine (T 4 ) to T 3 conversion by DIO2 in BAT and mediated by altered transcription factors expression associated with oxidative metabolism control in the liver. K E Y W O R D Sdeiodinase type II, metabolism, offspring, selenium supplementation, thyroid hormone | 1273 LAUREANO-MELO Et AL.

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Maternal RAS influence on the ontogeny of thirst

Cited by 15 publications

References 25 publications

Offspring’s hydromineral adaptive responses to maternal undernutrition during lactation

Offspring’s hydromineral adaptive responses to maternal undernutrition during lactation

Alimentary epigenetics: A developmental psychobiological systems view of the perception of hunger, thirst and satiety☆

Selenium supplementation during pregnancy and lactation promotes metabolic changes in Wistar rats' offspring

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