Maternal prolactin secretion during labor. The role of dopamine

Stefos, Theodor; Sotiriadis, Alexandros; Tsirkas, P.; Messinis, Ioannis E.; Lolis, D.

doi:10.1034/j.1600-0412.2001.800107.x

Cited by 9 publications

(4 citation statements)

References 39 publications

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“…In particular, an over-expression of NRG1 in transgenic mice [ 31 ] led to changes in dopamine metabolism. Stefos et al [ 32 ] showed that dopamine inhibited prolactin secretion both during labour and post-partum. Another dopamine function was related to the production of stress hormones such as adrenaline.…”

Section: Discussionmentioning

confidence: 99%

Detection of quantitative trait loci for maternal traits using high-density genotypes of Blonde d’Aquitaine beef cattle

et al. 2016

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BackgroundThe genetic determinism of the calving and suckling performance of beef cows is little known whereas these maternal traits are of major economic importance in beef cattle production systems. This paper aims to identify QTL regions and candidate genes that affect maternal performance traits in the Blonde d’Aquitaine breed. Three calving performance traits were studied: the maternal effect on calving score from field data, the calving score and pelvic opening recorded in station for primiparous cows. Three other traits related to suckling performance were also analysed: the maternal effect on weaning weight from field data, milk yield and the udder swelling score recorded in station for primiparous cows. A total of 2,505 animals were genotyped from various chip densities and imputed in high density chips for 706,791 SNP. The number of genotyped animals with phenotypes ranged from 1,151 to 2,284, depending on the trait considered.ResultsQTL detections were performed using a Bayes C approach. Evidence for a QTL was based on Bayes Factor values. Putative candidate genes were proposed for the QTL with major evidence for one of the six traits and for the QTL shared by at least two of the three traits underlying either calving or suckling performance. Nine candidate genes were proposed for calving performance among the nine highlighted QTL regions. The neuroregulin gene on chromosome 27 was notably identified as a very likely candidate gene for maternal calving performance. As for suckling abilities, seven candidate genes were identified among the 15 highlighted QTL. In particular, the Group-Specific Component gene on chromosome 6, which encodes vitamin D binding protein, is likely to have a major effect on maternal weaning weight in the Blonde d’Aquitaine breed. This gene had already been linked to milk production and clinical mastitis in dairy cattle.ConclusionIn the near future, these QTL findings and the preliminary proposals of candidate genes which act on the maternal performance of beef cows should help to identify putative causal mutations based on sequence data from different cattle breeds.Electronic supplementary materialThe online version of this article (doi:10.1186/s12863-016-0397-y) contains supplementary material, which is available to authorized users.

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Section: Discussionmentioning

confidence: 99%

Detection of quantitative trait loci for maternal traits using high-density genotypes of Blonde d’Aquitaine beef cattle

et al. 2016

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“…Previous studies demonstrated that serum PRL concentrations undergo rapid changes during delivery [48] , but the exact pattern still remains to be elucidated. Interestingly, PRL was found to have a dopaminergic influence during labor [49] , and a role in regulatory immune responses was noted in animal models [50] .…”

Section: Discussionmentioning

confidence: 99%

Women Serum Concentrations of the IL-10 Family of Cytokines and IFN-γ Decrease from the Third Trimester of Pregnancy to Active Labor

Reyes-Lagos

Peña-Castillo

Pérez‐Sánchez³

et al. 2017

Neuroimmunomodulation

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Labor is regarded as increased myometrial activity with a regular contractility pattern. At this final stage of pregnancy, myometrial quiescence is lost, accompanied by altered immune homeostasis. It is well known that the interleukin (IL)-10 family of cytokines modulates immunological responses mainly in epithelial cells, including the endometrium. To investigate their inflammatory profile during labor, we performed a longitudinal study in a group of healthy pregnant women (n = 20) with uncomplicated pregnancies in the third trimester of pregnancy and during active labor. Blood was sampled from pregnant women in the third trimester (gestational age 32-38 weeks, mean 36 ± 2 weeks) and during active labor (39-41 weeks of gestation, mean 40 ± 1 weeks). Serum levels of several cytokines were measured using multiplex immunoassays for both stages, indicating that the concentrations of IL-10, IL-20, IL-22, IL-28A, and interferon (IFN)-γ were significantly decreased during active labor in comparison with third-trimester levels (p < 0.05). Our analysis did not find significant correlations between IL-10, IL-20, IL-22, IL-28A, and IFN-γ levels and gestational age. However, our data suggest that the systemic downregulation of several members of the IL-10 family of cytokines plays an important role in the activation of myometrial smooth cells associated with uterine contractions during active labor. Downregulation of this IL-10 family of cytokines seems to coincide with the well-reported functional progesterone withdrawal during labor. Likewise, lower plasma IFN-γ concentrations may indicate a role for IFN-γ in active labor.

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“…Third is the antiemetic effect 22. [Last,] metoclopramide-induced hyperprolactinemia could potentially enhance the onset of breastfeeding, although this is questionable 23. Because unnecessary frequent vaginal examinations are not convenient to the patient and increase the risks of ascending infection, 1-2 hours intervals for repeat vaginal examination were chosen in accordance with the standard hospital intrapartum management protocol.…”

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confidence: 99%

Use of an antiemetic to shorten the length of labor in nulliparous women, exploring a potential role of an old drug: A randomized controlled trial

Ellaithy

Rasheed²,

Shafik³

et al. 2019

Intl J Gynecology & Obste

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Objective To assess whether metoclopramide is effective in shortening the duration of the first stage of labor in primiparous women. Methods The present randomized, double‐blind, placebo‐controlled trial was conducted at King Faisal Hospital, Saudi Arabia (between July 30, 2013, and September 1, 2016), and sequentially recruited young nulliparous women admitted in spontaneous active labor with or without ruptured membranes. Eligible participants were randomly assigned to receive a slow intravenous injection of either metoclopramide or placebo and consistently managed according to the local institutional intrapartum protocol and received identical monitoring and supportive care. The primary outcome was the cervical dilatation rate. Results Fifty‐nine women were included in the metoclopramide group and 52 in the placebo group. The first stage of labor was significantly shorter in the metoclopramide group (203 minutes vs 230 minutes in the placebo group, P=0.019), with a faster cervical dilatation rate (2.4 ± 0.4 cm/h vs 1.9 ± 0.5 cm/h in the placebo group, P<0.001) and shorter interval from treatment administration until full cervical dilatation. There was a significantly higher probability of faster delivery among women who were treated with metoclopramide (log‐rank test, χ2=5.997, P=0.014). Conclusion Metoclopramide safely reduced the duration of the first stage of labor and was not associated with major maternal or neonatal adverse outcomes. ClinicalTrials.gov NCT01937234

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Maternal prolactin secretion during labor. The role of dopamine

Abstract: The different PRL values between the three groups show that maternal PRL is still under dopaminergic influence during labor. However, the fact that PRL levels exhibit the same multiphasic pattern, suggests that there are factors other than dopamine, which strongly influence this pattern.

Cited by 9 publications

References 39 publications

Detection of quantitative trait loci for maternal traits using high-density genotypes of Blonde d’Aquitaine beef cattle

Detection of quantitative trait loci for maternal traits using high-density genotypes of Blonde d’Aquitaine beef cattle

Women Serum Concentrations of the IL-10 Family of Cytokines and IFN-γ Decrease from the Third Trimester of Pregnancy to Active Labor

Use of an antiemetic to shorten the length of labor in nulliparous women, exploring a potential role of an old drug: A randomized controlled trial

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Maternal prolactin secretion during labor. The role of dopamine

Abstract: The different PRL values between the three groups show that maternal PRL is still under dopaminergic influence during labor. However, the fact that PRL levels exhibit the same multiphasic pattern, suggests that there are factors other than dopamine, which strongly influence this pattern.

Cited by 9 publications

References 39 publications

Detection of quantitative trait loci for maternal traits using high-density genotypes of Blonde d’Aquitaine beef cattle

Detection of quantitative trait loci for maternal traits using high-density genotypes of Blonde d’Aquitaine beef cattle

Women Serum Concentrations of the IL-10 Family of Cytokines and IFN-&#x03B3; Decrease from the Third Trimester of Pregnancy to Active Labor

Use of an antiemetic to shorten the length of labor in nulliparous women, exploring a potential role of an old drug: A randomized controlled trial

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Women Serum Concentrations of the IL-10 Family of Cytokines and IFN-γ Decrease from the Third Trimester of Pregnancy to Active Labor