Maternal pre-eclampsia as a risk factor for necrotizing enterocolitis

Perger, Lena; Mukhopadhyay, Dhriti; Komidar, Luka; Wiggins-Dohlvik, Katie; Uddin, Mohammad Nasir; Beeram, Madhava R.

doi:10.3109/14767058.2015.1076386

Cited by 35 publications

(22 citation statements)

References 28 publications

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“…The literature is inconclusive. A protective effect of maternal hypertensive disorders has been reported[ 4 ] but also positive associations of PE with NEC at least in some subgroups[ 24 , 25 ]. The number of NEC cases in our population was, however, considerably larger than in those studies, and many possible mediating factors were controlled for in the multivariable analysis.…”

Section: Discussionmentioning

confidence: 99%

Maternal, fetal and perinatal factors associated with necrotizing enterocolitis in Sweden. A national case-control study

et al. 2018

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ObjectiveTo analyze associations of maternal, fetal, gestational, and perinatal factors with necrotizing enterocolitis in a matched case-control study based on routinely collected, nationwide register data.Study designAll infants born in 1987 through 2009 with a diagnosis of necrotizing enterocolitis in any of the Swedish national health care registers were identified. For each case up to 6 controls, matched for birth year and gestational age, were selected. The resulting study population consisted of 720 cases and 3,567 controls. Information on socioeconomic data about the mother, maternal morbidity, pregnancy related diagnoses, perinatal diagnoses of the infant, and procedures in the perinatal period, was obtained for all cases and controls and analyzed with univariable and multivariable logistic regressions for the whole study population as well as for subgroups according to gestational age.ResultsIn the study population as a whole, we found independent positive associations with necrotizing enterocolitis for isoimmunization, fetal distress, cesarean section, neonatal bacterial infection including sepsis, erythrocyte transfusion, persistent ductus arteriosus, cardiac malformation, gastrointestinal malformation, and chromosomal abnormality. Negative associations were found for maternal weight, preeclampsia, maternal urinary infection, premature rupture of the membranes, and birthweight. Different patterns of associations were seen in the subgroups of different gestational age.ConclusionWith some interesting exceptions, especially in negative associations, the results of this large, population based study, are in keeping with earlier studies. Although restrained by the limitations of register data, the findings mirror conceivable pathophysiological processes and underline that NEC is a multifactorial disease.

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Section: Discussionmentioning

confidence: 99%

Maternal, fetal and perinatal factors associated with necrotizing enterocolitis in Sweden. A national case-control study

et al. 2018

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“…Mothers with preeclampsia, an important indication for antenatal MgSO 4 , were excluded because the maternal environment in this condition can affect vascular development of the intestine. [27,28]…”

Section: Discussionmentioning

confidence: 99%

Antenatal Magnesium Sulfate Reduced Intestinal Morbidities Requiring Surgery in Preterm Infants With Extremely Low Gestational Age: A Retrospective Cohort Study

Kim¹,

Kim²,

Shin³

et al. 2020

Preprint

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Background Antenatal magnesium sulfate is widely used as a tocolytic, for maternal seizures, and for seizure prophylaxis in preeclampsia. Recent studies have suggested that antenatal magnesium sulfate use is associated with favorable neurodevelopmental outcomes in preterm infants. However, there are concerns regarding the neonatal effects of antenatal magnesium sulfate, especially regarding gastrointestinal morbidities. This study aims to explore the effects of antenatal magnesium sulfate on intestinal morbidities requiring surgery in preterm infants.Methods This was a retrospective cohort study of 181 preterm infants who were born at less than 28 weeks of gestational age. Subjects were categorized as infants exposed to antenatal magnesium sulfate and those not exposed to antenatal magnesium sulfate.Results Antenatal magnesium sulfate was associated with a lower incidence of surgical conditions of the intestine (OR 0.393, 95% CI 0.170–0.905). Multivariate analysis showed that the duration of antenatal magnesium sulfate use was associated with surgical conditions of the intestine (adjusted OR 0.766, 95% CI 0.589–0.997). In the < 26 weeks of gestational age subgroup, use of antenatal magnesium sulfate was significantly associated with decreased intestinal morbidities requiring surgery (adjusted OR 0.234, 95% CI 0.060–0.922).Conclusion Antenatal magnesium sulfate use appears to have a protective effect on intestinal morbidities requiring surgery in preterm infants in a duration-dependent manner. Association of antenatal magnesium sulfate use and decreased intestinal morbidities requiring surgery was more distinct in preterm infants < 26 weeks of gestational age.

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“…Çalışmamızda da, anormal antenatal Doppler USG, NEK gelişen olgularda anlamlı ölçüde daha yüksek oranda (%50) saptandı. Preeklampsi ve gebeliğe bağlı gelişen hipertansiyonun, prematüre bebeklerde NEK için önemli bir risk faktörü olabileceği bildirilmektedir (19)(20)(21) . Nekrotizan enterokolit gelişen ve gelişmeyen olgularımızda maternal hipertansiyon/preeklampsi sıklığı açısından anlamlı fark saptamadık.…”

Section: Discussionunclassified

An Important Cause of Morbidity in Preterm Babies; Necrotizing enterocolitis: A Two-year Evaluation

Özdemir¹,

Bilgen²,

Cerit³

et al. 2019

BUCH

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Beş olguya cerrahi laparotomi ve rezeksiyon uygulanırken, bir bebeğe yatak başı "penröz" dren takıldı. Bu olguların ortalama doğum ağırlığı ve gebelik haftası cerrahi gerekmeyenlere göre anlamlı ölçüde daha düşük saptandı (p:0.015; p:0.042). Bebeklerin %3,5'inde transfüzyon ilişkili NEK saptandı. NEK gelişen bebeklerde mortalite oranı %40 olarak bulundu. Sonuç: Özellikle daha düşük gestasyon haftası ve çok düşük doğum ağırlığı olan prematüre bebeklerden, minimal enteral beslenmeyi tolere edemeyen, anormal Doppler bulguları olan ve kan transfüzyonu uygulanan prematüreler daha dikkatli izlenmelidir.

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Maternal pre-eclampsia as a risk factor for necrotizing enterocolitis

Abstract: Maternal PE is an independent risk factor for the development of NEC in some sub-groups of babies, most notably with IUGR. Fetal hypoxia caused by abnormal placentation in PE leads to restricted growth, and may be the underlying mechanism that predisposes the newborn to NEC.

Cited by 35 publications

References 28 publications

Maternal, fetal and perinatal factors associated with necrotizing enterocolitis in Sweden. A national case-control study

Maternal, fetal and perinatal factors associated with necrotizing enterocolitis in Sweden. A national case-control study

Antenatal Magnesium Sulfate Reduced Intestinal Morbidities Requiring Surgery in Preterm Infants With Extremely Low Gestational Age: A Retrospective Cohort Study

An Important Cause of Morbidity in Preterm Babies; Necrotizing enterocolitis: A Two-year Evaluation

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