Maternal periconceptional alcohol consumption and congenital heart defects

Zhu, Yong; Romitti, Paul A.; Conway, Kristin M; Shen, Dereck; Sun, Lin; Browne, Marilyn L.; Botto, Lorenzo D.; Lin, Angela E.; Druschel, Charlotte M.

doi:10.1002/bdra.23352

Cited by 31 publications

(35 citation statements)

References 52 publications

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“…In our analyses, smoking and alcohol use were unexpectedly found to be negatively associated with PCG. While smoking and alcohol are considered risk factors for many birth defects and other adverse pregnancy outcomes, findings of negative association have been reported for some specific birth defects in other analyses based on case–control data in the U.S. (Carmichael, Ma, Shaw, & the National Birth Defects Prevention Study, ; Caspers Conway et al, ; Grewel, Carmichael, Ma, Lammer, & Shaw, ; Zhu et al, ). These findings could reflect true associations; potential mechanisms cited include vasoactive effects, endocrine effects, or antiangiogenic factors (Carmichael et al, ).…”

Section: Discussionmentioning

confidence: 93%

Risk factors for primary congenital glaucoma in the National Birth Defects Prevention Study

Forestieri

Desrosiers

Freedman

et al. 2019

American J of Med Genetics Pt A

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Primary congenital glaucoma (PCG) is a rare but serious birth defect. Genetic mutations have been implicated in the development of PCG, but little is known about nongenetic risk factors. This study investigates potential risk factors for PCG in the National Birth Defects Prevention Study (NBDPS), a large population-based case-control study of major birth defects in the United States. The analysis includes case infants with PCG (N = 107) and control infants without birth defects (N = 10,084) enrolled in NBDPS from birth years 2000-2011. Pregnancy/infant clinical characteristics, demographics, and parental health history were collected through maternal interview. Adjusted odds ratios (aORs) and 95% confidence intervals (CIs) were computed to examine associations with all PCG cases and isolated PCG cases without other major malformations.Associations with all the cases included term low birth weight (<2,500 g; aOR = 2.80, CI 1.59-4.94), non-Hispanic black maternal race/ethnicity (aOR = 2.42, CI 1.42-4.13), maternal history of seizure (aOR = 2.73, CI 1.25-5.97), maternal antihypertensive use (aOR = 3.60, CI 1.52-8.53), and maternal sexually transmitted infection (aOR = 2.75, CI 1.17-6.44). These factors were also associated with isolated PCG, as was maternal use of nonsteroidal anti-inflammatory drugs (aOR = 2.70, CI 1.15-6.34). This study is among the first to examine a wide array of potential risk factors for PCG in a population-based sample.

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Section: Discussionmentioning

confidence: 93%

Risk factors for primary congenital glaucoma in the National Birth Defects Prevention Study

Forestieri

Desrosiers

Freedman

et al. 2019

American J of Med Genetics Pt A

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“…A large National Birth Defects Prevention Study estimated associations between congenital heart defects (CHDs) and case or control mother reports of periconceptional alcohol consumption (i.e., any consumption) with expected delivery dates during 1997 to 2007. The results of the study suggested that there are no statistically significant increased risks between measures of maternal alcohol consumption and most CHDs examined (Zhu et al, ).…”

Section: Introductionmentioning

confidence: 97%

Acute alcohol exposure during mouse gastrulation alters lipid metabolism in placental and heart development: Folate prevention

Linask

Han

2016

Birth Defects Research

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BackgroundEmbryonic acute exposure to ethanol (EtOH), lithium, and homocysteine (HCy) induces cardiac defects at the time of exposure; folic acid (FA) supplementation protects normal cardiogenesis (Han et al., 2009, 2012; Serrano et al., 2010). Our hypothesis is that EtOH exposure and FA protection relate to lipid and FA metabolism during mouse cardiogenesis and placentation.MethodsOn the morning of conception, pregnant C57BL/6J mice were placed on either of two FA‐containing diets: a 3.3 mg health maintenance diet or a high FA diet of 10.5 mg/kg. Mice were injected a binge level of EtOH, HCy, or saline on embryonic day (E) 6.75, targeting gastrulation. On E15.5, cardiac and umbilical blood flow were examined by ultrasound. Embryonic cardiac tissues were processed for gene expression of lipid and FA metabolism; the placenta and heart tissues for neutral lipid droplets, or for medium chain acyl‐dehydrogenase (MCAD) protein.ResultsEtOH exposure altered lipid‐related gene expression on E7.5 in comparison to control or FA‐supplemented groups and remained altered on E15.5 similarly to changes with HCy, signifying FA deficiency. In comparison to control tissues, the lipid‐related acyl CoA dehydrogenase medium length chain gene and its protein MCAD were altered with EtOH exposure, as were neutral lipid droplet localization in the heart and placenta.ConclusionEtOH altered gene expression associated with lipid and folate metabolism, as well as neutral lipids, in the E15.5 abnormally functioning heart and placenta. In comparison to controls, the high FA diet protected the embryo and placenta from these effects allowing normal development. Birth Defects Research (Part A) 106:749–760, 2016. © 2016 The Authors Birth Defects Research Part A: Clinical and Molecular Teratology Published by Wiley Periodicals, Inc.

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“…Although ethanol abstinence during pregnancy is recommended, more than 20% of pregnant women worldwide continue to abuse ethanol (Chang et al, ). Maternal ethanol consumption during pregnancy may have important teratogenic effects and result in many birth defects like face and brain anomalies, cognitive and growth delay, and fetal neurological and behavioral problems, depending on the time, dose, and length of exposure (Barr and Streissguth, ; Hoyme et al, ; May et al, ; O'Leary et al, ; Zhu et al, ). Among all alterations resulting from prenatal fetal exposure to ethanol, growth delay is one of the most consistent discoveries in clinical and experimental studies (Lee and Leichter, , ; Day et al, , ; Weinberg et al, ; Keiver et al, , ; Keiver and Weinberg, ; Simpson et al, ; Ramadoss et al, ; Probyn et al, ).…”

Section: Introductionmentioning

confidence: 99%

High doses of alcohol during pregnancy cause DNA damages in osteoblasts of newborns rats

Carvalho

Dutra

Andrade

et al. 2015

Birth Defects Research

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Maternal periconceptional alcohol consumption and congenital heart defects

Cited by 31 publications

References 52 publications

Risk factors for primary congenital glaucoma in the National Birth Defects Prevention Study

Risk factors for primary congenital glaucoma in the National Birth Defects Prevention Study

Acute alcohol exposure during mouse gastrulation alters lipid metabolism in placental and heart development: Folate prevention

High doses of alcohol during pregnancy cause DNA damages in osteoblasts of newborns rats

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