Maternal occupational exposures to nanoscale particles and small for gestational age outcome in the French Longitudinal Study of Children

Manangama, Guyguy; Migault, Lucile; Audignon-Durand, Sabyne; Gramond, Céline; Zaros, Cécile; Bouvier, Ghislaine; Brochard, Patrick; Sentilhes, Loïc; Lacourt, Aude; Delva, Fleur

doi:10.1016/j.envint.2018.11.027

Cited by 15 publications

(10 citation statements)

References 41 publications

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“…Other reports showed that the intratracheal instillation of MWCNTs at a single dose (67 µg/mouse) interfered with ovulation; however, no significant alterations in litter or gestational parameters, such as implantations, sex ratio, litter size, and implantation loss, were observed [26,71]. The repeated oral administration of MWCNTs (8,40,200, or 1000 mg/kg) during organogenesis (GD6-GD19) did not induce alterations in gestational parameters [72,73]. These results indicated that NP administration routes affected fetal toxicities, with oral administration or via inhalation showing less toxicities than intravenous injection.…”

Section: Introductionmentioning

confidence: 97%

Fetotoxicity of Nanoparticles: Causes and Mechanisms

et al. 2021

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The application of nanoparticles in consumer products and nanomedicines has increased dramatically in the last decade. Concerns for the nano-safety of susceptible populations are growing. Due to the small size, nanoparticles have the potential to cross the placental barrier and cause toxicity in the fetus. This review aims to identify factors associated with nanoparticle-induced fetotoxicity and the mechanisms involved, providing a better understanding of nanotoxicity at the maternal–fetal interface. The contribution of the physicochemical properties of nanoparticles (NPs), maternal physiological, and pathological conditions to the fetotoxicity is highlighted. The underlying molecular mechanisms, including oxidative stress, DNA damage, apoptosis, and autophagy are summarized. Finally, perspectives and challenges related to nanoparticle-induced fetotoxicity are also discussed.

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Section: Introductionmentioning

confidence: 97%

Fetotoxicity of Nanoparticles: Causes and Mechanisms

et al. 2021

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“…Small for gestational age infants are a major concern for pediatricians because these newborns not only have a high risk during the perinatal period but can also develop a series of problems during childhood and adulthood. Previous research studies have focused more on factors related to the occurrence of SGA ( Catov et al, 2008 ; Palatnik et al, 2016 ; Englund-Ogge et al, 2018 ; Li et al, 2018 ; Manangama et al, 2019 ), postnatal management ( Cardoso-Demartini et al, 2018 ; Visuthranukul et al, 2018 ), and health problems during growth ( Gur et al, 2018 ). However, the exact pathogenesis of SGA remains unknown.…”

Section: Discussionmentioning

confidence: 99%

The Maternal–Fetal Interface in Small-for-Gestational-Age Pregnancies Is Associated With a Reduced Quantity of Human Decidual NK Cells With Weaker Functional Ability

Lin

Yang

Feng

et al. 2020

Front. Cell Dev. Biol.

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Small for gestational age (SGA) refers to a birth weight that is less than the 10th percentile of the mean weight of infants at the same gestational age. This condition is associated with a variety of complications, and a high risk of cardiovascular and cerebrovascular diseases in adulthood. Decidual natural killer (dNK) cells at the maternal-fetal interface have received significant research attention in terms of normal pregnancy or miscarriage; however, data relating to SGA are limited. In this study, we aimed to investigate the characteristics and regulatory role of dNK cells at the maternal-fetal interface in SGA. Using immunofluorescence assays, we found that dNK cells maintained close contact with extra-villous trophoblasts, and the proportion of dNK cells in SGA decreased more than in appropriate for gestational age (AGA). Flow cytometry also showed that there was a significantly lower percentage of dNK cells in SGA (25.01 ± 2.43%) than in AGA (34.25 ± 2.30%) (p = 0.0103). The expression of the inhibitory receptor NKG2A on dNK cells and the secretion levels of both perforin and TGF-β1 from dNK cells were significantly higher in SGA than in AGA, while the cytotoxicity of dNK cells in SGA against K562 cells was attenuated. Compared to AGA, the functional ability of dNK cells in SGA showed significant functional impairment in promoting proliferation, migration, invasion, and tube formation in trophoblast cells or vascular endothelial cells. The abnormal function of dNK cells may affect fetal growth and development, and could therefore participate in the pathogenesis of SGA.

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“…They found, that in mothers who did not have a high absence from work, and who were also exposed to iron‐containing particles throughout their gestation, there were statistically significant increased risks for babies being born small for gestational age, low birth weight, or preterm. A recent longitudinal study conducted by Manangama et al was also able to link maternal occupational exposures to nanoparticles to babies being born small for gestational age but made no mention of welders.…”

Section: Discussionmentioning

confidence: 99%

Mild steel and stainless steel welding fumes elicit pro‐inflammatory and pro‐oxidant effects in first trimester trophoblast cells

Olgun

Morris

Bowers

et al. 2020

American J Rep Immunol

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Problem As more women join the skilled‐trade workforce, the effects of workplace exposures on pregnancy need to be explored. This study aims to identify the effects of mild steel and stainless steel welding fume exposures on cultured placental trophoblast cells. Method of study Welding fumes (mild steel and stainless steel) were generously donated by Lincoln Electric. Electron microscopy was used to characterize welding fume particle size and the ability of particles to enter extravillous trophoblast cells (HTR‐8/SVneo). Cellular viability, free radical production, cytokine production, and ability of cells to maintain invasive properties were analyzed, respectively, by WST‐1, electron paramagnetic resonance, DCFH‐DA, V‐plex MULTI‐SPOT assay system, and a matrix gel invasion assay. Results For all three welding fume types, average particle size was <210 nm. HTR‐8/SVneo cells internalized welding particles, and nuclear condensation was observed. Cellular viability was significantly decreased at the high dose of 100 µg/mL for all three welding fumes, and stainless steel generated the greatest production of the hydroxyl radical, and intracellular reactive oxygen species. Production of the cytokines IL‐1β and TNFα were not observed in response to welding fume exposure, but IL‐6 and IL‐8 were. Finally, the invasive capability of cells was decreased upon exposure to both mild steel and stainless steel welding fumes. Conclusion Welding fumes are cytotoxic to extravillous trophoblasts, as is evident by the production of free radicals, pro‐inflammatory cytokines, and the observed decrease in invasive capabilities.

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Maternal occupational exposures to nanoscale particles and small for gestational age outcome in the French Longitudinal Study of Children

Cited by 15 publications

References 41 publications

Fetotoxicity of Nanoparticles: Causes and Mechanisms

Fetotoxicity of Nanoparticles: Causes and Mechanisms

The Maternal–Fetal Interface in Small-for-Gestational-Age Pregnancies Is Associated With a Reduced Quantity of Human Decidual NK Cells With Weaker Functional Ability

Mild steel and stainless steel welding fumes elicit pro‐inflammatory and pro‐oxidant effects in first trimester trophoblast cells

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