Fetotoxicity of Nanoparticles: Causes and Mechanisms

Teng, Chuanfeng; Jiang, Cuijuan; Gao, Sulian; Liu, Xiaojing; Zhai, Shumei

doi:10.3390/nano11030791

Cited by 23 publications

(17 citation statements)

References 164 publications

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“…It has been reported that during pregnancy, the nonbiologically produced SNPs may enter the body and transfer from mother to her offspring. They can damage the cell membrane, DNA, and other important parts of the cell (Teng et al., 2021). In vitro analysis, it has been shown that exposure of the embryonic cells to the nonbiologically produced SNPs could up‐ and down regulate several genes.…”

Section: Discussionmentioning

confidence: 99%

Comparison of the possible histopathological changes of the rat neonatal cerebellum induced by toxic and nontoxic doses of biological silver nanoparticles with chemical silver nanoparticles

2021

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Introduction: Today, due to the increasing application of silver nanoparticles in medical products, it is necessary to pay attention to the user's safety. There are three methods, namely, chemical, physical, and biological, used for the production of nanoparticles.Although the first two methods might introduce health hazards, the latter is hypothetically safe. In this study, we examined the histopathological changes in the cerebellum of neonatal Wistar rats induced by injection of toxic and nontoxic doses of silver nanoparticles, which were produced by green synthetic method and were compared with chemical silver nanoparticles.Methods: This study was a laboratory interventional study performed on 25 Wistar rats in the Animal Laboratory of Islamic Azad University of Shahrood. These rats were divided into five groups of the control group, the group with nonpoisonous injection of chemical nanoparticles, the group with nonpoisonous injection of biological nanoparticles, the group with injection of poisonous chemical nanoparticles, and the group with injection of poisonous biological nanoparticles. The rats were impregnated by the males of the same race and the cerebellum of their offspring was studied after birth. Results:We found that the injection of nonpoisonous chemical nanoparticles caused hyperemia, inappropriate size, and dark cytoplasm in some Purkinje cells. Also, injection of poisonous chemical nanoparticles caused hyperemia and cellular dispersion in the molecular layer, caused abnormal shapes, and reduced the number of cells in Purkinje cells. However, injection of poisonous and nonpoisonous biological nanoparticles did not alter cerebellum cells nor did it cause any inflammation or hyperemia. Conclusion:In contrast with chemical nanoparticles, biological nanoparticles have less significant effect on the cerebellum cells. K E Y W O R D Sbiological silver nanoparticles, cerebellum, chemical silver nanoparticles, histopathology, neonatal ratThis is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Section: Discussionmentioning

confidence: 99%

Comparison of the possible histopathological changes of the rat neonatal cerebellum induced by toxic and nontoxic doses of biological silver nanoparticles with chemical silver nanoparticles

2021

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“…The described mechanisms have been associated with nanomaterial-induced adverse effects in the liver [ 55 ] and the brain [ 56 ], among other organs, with important repercussions observed in the offspring as well [ 57 ]. Compared to bigger-sized homologous materials, the enlarged surface area of nanomaterials comes with increased reactivity, which seems to be the main driver for the observed overproduction of ROS.…”

Section: Nanotoxicologymentioning

confidence: 99%

Nanosafety: An Evolving Concept to Bring the Safest Possible Nanomaterials to Society and Environment

et al. 2022

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The use of nanomaterials has been increasing in recent times, and they are widely used in industries such as cosmetics, drugs, food, water treatment, and agriculture. The rapid development of new nanomaterials demands a set of approaches to evaluate the potential toxicity and risks related to them. In this regard, nanosafety has been using and adapting already existing methods (toxicological approach), but the unique characteristics of nanomaterials demand new approaches (nanotoxicology) to fully understand the potential toxicity, immunotoxicity, and (epi)genotoxicity. In addition, new technologies, such as organs-on-chips and sophisticated sensors, are under development and/or adaptation. All the information generated is used to develop new in silico approaches trying to predict the potential effects of newly developed materials. The overall evaluation of nanomaterials from their production to their final disposal chain is completed using the life cycle assessment (LCA), which is becoming an important element of nanosafety considering sustainability and environmental impact. In this review, we give an overview of all these elements of nanosafety.

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“…Natality, reproducibility, and developmental paradigms of the fetus are necessities for sustaining any species, underlining the significance of arising general public cognizance regarding the nanoparticles’ toxicities on reproductive health. Women possess somewhere around few hundreds of follicles which attain a mature stage and experience ovulation in their lifetimes, signifying the quite circumscribed and confined opportunities for reproduction ( Teng et al, 2021 ). Furthermore, the female reproductive system, which includes the ovaries and uterus, demonstrates periodical maturation, development, and regenerative phenomena which are well-governed by a specific set of hormones.…”

Section: Toxic Effects Of Engineered Nanoparticles On Reproduction An...mentioning

confidence: 99%

“…Nanoparticle characteristics viz., hydrodynamic diameter (particle) size, surface morphologies, and their composition; other chemistries play significant roles and regulate the fetal toxicity after the maternal exposure to nanoparticles during pregnancy. Furthermore, maternal circumstances and routes of nanoparticles’ exposure critically control the nanoparticle-induced fetal anomalies (reproduced with permission from ( Teng et al, 2021 ).…”

Section: Consequences Of Nanoparticle Toxicity On Fetal Abnormalitiesmentioning

confidence: 99%

Safety and Toxicity Implications of Multifunctional Drug Delivery Nanocarriers on Reproductive Systems In Vitro and In Vivo

Ahmad

2022

Front. Toxicol.

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In the recent past, nanotechnological advancements in engineered nanomaterials have demonstrated diverse and versatile applications in different arenas, including bio-imaging, drug delivery, bio-sensing, detection and analysis of biological macromolecules, bio-catalysis, nanomedicine, and other biomedical applications. However, public interests and concerns in the context of human exposure to these nanomaterials and their consequential well-being may hamper the wider applicability of these nanomaterial-based platforms. Furthermore, human exposure to these nanosized and engineered particulate materials has also increased drastically in the last 2 decades due to enormous research and development and anthropocentric applications of nanoparticles. Their widespread use in nanomaterial-based industries, viz., nanomedicine, cosmetics, and consumer goods has also raised questions regarding the potential of nanotoxicity in general and reproductive nanotoxicology in particular. In this review, we have summarized diverse aspects of nanoparticle safety and their toxicological outcomes on reproduction and developmental systems. Various research databases, including PubMed and Google Scholar, were searched for the last 20 years up to the date of inception, and nano toxicological aspects of these materials on male and female reproductive systems have been described in detail. Furthermore, a discussion has also been dedicated to the placental interaction of these nanoparticles and how these can cross the blood–placental barrier and precipitate nanotoxicity in the developing offspring. Fetal abnormalities as a consequence of the administration of nanoparticles and pathophysiological deviations and aberrations in the developing fetus have also been touched upon. A section has also been dedicated to the regulatory requirements and guidelines for the testing of nanoparticles for their safety and toxicity in reproductive systems. It is anticipated that this review will incite a considerable interest in the research community functioning in the domains of pharmaceutical formulations and development in nanomedicine-based designing of therapeutic paradigms.

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Fetotoxicity of Nanoparticles: Causes and Mechanisms

Cited by 23 publications

References 164 publications

Comparison of the possible histopathological changes of the rat neonatal cerebellum induced by toxic and nontoxic doses of biological silver nanoparticles with chemical silver nanoparticles

Comparison of the possible histopathological changes of the rat neonatal cerebellum induced by toxic and nontoxic doses of biological silver nanoparticles with chemical silver nanoparticles

Nanosafety: An Evolving Concept to Bring the Safest Possible Nanomaterials to Society and Environment

Safety and Toxicity Implications of Multifunctional Drug Delivery Nanocarriers on Reproductive Systems In Vitro and In Vivo

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