Maternal Level of 25-Hydroxyvitamin D during Pregnancy Associated with Risk of Type 1 Diabetes in the Offspring, a Meta-Analysis

Kang, Xinyi; Cui, Jiawen; Zhang, Mingjin; Wang, Ying; Tang, Wei-Chun; Chen, Liping

doi:10.3177/jnsv.66.402

Cited by 3 publications

(2 citation statements)

References 22 publications

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“…Following deduplication, 673 meta-analyses remained, which underwent title and abstract screening with 123 meta-analyses selected for full-text screening. Finally, 16 meta-analyses met the inclusion criteria for this umbrella review [15][16][17][18][22][23][24][25][26][27][28][29][30][31][32][33][34].…”

Section: Search Resultsmentioning

confidence: 99%

“…Furthermore, a low level of vitamin D ( < 50 nmol/L) significantly decreased the mental development score in the child (MD = −1.12; 95% CI = −1.82 ~−0.42; number of studies = 9; Table 2B) in comparison to a high level (>50 nmol/ L) of vitamin D [32]. Children with type 1 diabetes had significantly lower maternal levels of vitamin D compared to children without type 1 diabetes (MD = −2.54; 95% CI = −4.65 ~−0.44; number of studies = 8; Table 2A) [33].…”

Section: Vitamin D In Pregnancy Related To Health Outcomes In Observa...mentioning

confidence: 99%

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Effects of vitamin D in pregnancy on maternal and offspring health-related outcomes: An umbrella review of systematic review and meta-analyses

Chien,

Huang,

Wang

et al. 2024

Nutr. Diabetes

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Background Vitamin D deficiency has been linked with several adverse maternal and fetal outcomes. Objective To summarize systematic reviews and meta-analyses evaluating the effects of vitamin D deficiency and of vitamin D supplementation in pregnancy on maternal and offspring health-related outcomes. Methods Prior to conducting this umbrella review, we registered the protocol in PROSPERO (CRD42022368003). We conducted searches in PubMed, Embase, and Cochrane Library for systematic reviews and meta-analyses on vitamin D in pregnancy, from database inception to October 2, 2023. All outcomes related to vitamin D in pregnancy obtained from the systematic reviews and meta-analyses were extracted. Data Extraction: Two reviewers independently chose studies and collected information on health outcomes. The quality of the included articles’ methodology was assessed using AMSTAR 2 (A Measurement Tool to Assess Systematic Reviews–2). Results We identified 16 eligible systematic reviews and meta-analyses, which included 250,569 women. Our results demonstrated that vitamin D deficiency in pregnancy is associated with increased risk of preterm birth, small-for gestational age/low birth weight infants, recurrent miscarriage, bacterial vaginosis and gestational diabetes mellitus. Vitamin D supplementation in pregnancy increases birth weight, and reduces the risk of maternal pre-eclampsia, miscarriage, and vitamin D deficiency, fetal or neonatal mortality, as well as attention-deficit hyperactivity disorder, and autism spectrum disorder in childhood. In women with gestational diabetes mellitus, vitamin D supplementation in pregnancy can reduce the risk of maternal hyperbilirubinemia, polyhydramnios, macrosomia, fetal distress, and neonatal hospitalization. Conclusion Due to the association with adverse maternal and offspring health outcomes, we recommend the vitamin D status in pregnancy should be monitored, particularly in women at high risk of vitamin D deficiency. It is suggested that pregnant women take a dose of >400 IU/day of vitamin D supplementation during pregnancy to prevent certain adverse outcomes.

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Section: Search Resultsmentioning

confidence: 99%

Section: Vitamin D In Pregnancy Related To Health Outcomes In Observa...mentioning

confidence: 99%

Effects of vitamin D in pregnancy on maternal and offspring health-related outcomes: An umbrella review of systematic review and meta-analyses

Chien,

Huang,

Wang

et al. 2024

Nutr. Diabetes

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Vitamin D and type 1 diabetes

Martens,

Gysemans,

Mathieu

2024

Feldman and Pike's Vitamin D

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The Influence of Vitamin D on Pregnancy and Outcomes: Current Knowledge and Future Perspectives

Kurmangali,

Abdykalykova,

Kurmangali

et al. 2024

Gynecol Obstet Invest

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Introduction: The purpose of the research was to explore the relationship between pathology and pregnancy outcomes with serum 25-hydroxycholecalciferol levels and vitamin D supplementation. Methods: A literature search was performed for systematic literature reviews published between January 2018 and February 2023. Forty-two publications were selected for further analysis. Results: This study demonstrates that elevated maternal serum 25(OH)D levels are associated with a decreased risk of preterm labour and various pregnancy-related health issues, highlighting the protective benefits of adequate vitamin D during pregnancy. Conclusion: Vitamin D supplementation during pregnancy at a dose of 2,000 IU or higher is preventive for pre-eclampsia, insulin resistance, and the development of bronchial asthma in early childhood. Vitamin D screening is indicated for all pregnant women. Dosages of vitamin D preparations should be determined individually, considering laboratory tests and risk factors.

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Maternal Level of 25-Hydroxyvitamin D during Pregnancy Associated with Risk of Type 1 Diabetes in the Offspring, a Meta-Analysis

Cited by 3 publications

References 22 publications

Effects of vitamin D in pregnancy on maternal and offspring health-related outcomes: An umbrella review of systematic review and meta-analyses

Effects of vitamin D in pregnancy on maternal and offspring health-related outcomes: An umbrella review of systematic review and meta-analyses

Vitamin D and type 1 diabetes

The Influence of Vitamin D on Pregnancy and Outcomes: Current Knowledge and Future Perspectives

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