Maternal isobutyl-paraben exposure alters anxiety and passive avoidance test performance in adult male rats

Kawaguchi, Maiko; Irie, Kaoru; Morohoshi, Kaori; Watanabe, Gen; Taya, Kazuyoshi; Morita, Masatoshi; Kondo, Yasuhiko; Imai, Hideki; Himi, Toshiyuki

doi:10.1016/j.neures.2009.06.011

Cited by 27 publications

(16 citation statements)

References 35 publications

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“…Fourteen-week-old Haa and Laa rats underwent passive avoidance test as described previously [22]. a step-through type passive avoidance test unit (Pa-3001, o'Hara & co., tokyo, Japan) comprised of a bright and dark compartment was used.…”

Section: Passive Avoidance Taskmentioning

confidence: 99%

“…in the laboratory, there are 2 major behavioral paradigms of avoidance learning tasks in rats, such as active and passive avoidance tasks [22,30]. For the shuttle-box active avoidance task [30], an animal is first given light and buzzer alarms as condition stimuli (cS) and continuously given foot shocks as unconditioned stimuli (uS).…”

Section: Introductionmentioning

confidence: 99%

“…thus, freezing rats might show low avoidance rates regardless of cS learning in the active task. For the step-through type passive avoidance task [22], the apparatus consisted of 2 chambers, light and dark boxes. once an animal is placed in the light box, it quickly moves to dark box because rodents prefer darker places in nature.…”

Section: Introductionmentioning

confidence: 99%

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Male Hatano High-Avoidance Rats Show High Avoidance and High Anxiety-Like Behaviors as Compared with Male Low-Avoidance Rats

et al. 2012

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Our prime objective was to establish an optimal model animal for studying avoidance learning and memory in rodents. The two-way rat inbred strains of Hatano high-(HAA) and lowavoidance (LAA) animals were originally selected and bred in accordance with their high or low performance respectively in the shuttle-box active avoidance task. Previous studies demonstrated that they have clear strain differences in endocrine stress response, which is related to acquisition of aversive learning and emotional reactivity. To evaluate the effect of selection by the shuttle-box task on avoidance performance and emotional reactivity, male Hatano rats underwent passive avoidance, open field and elevated plus maze tests. The present results show that the avoidance performance in the passive task was significantly greater in HAA rats than in LAA rats. Furthermore, HAA rats showed high anxiety-like behaviors compared with LAA rats in open field and elevated plus maze tests. Taken together, this study demonstrated that 1) selection and breeding of Hatano HAA and LAA strain rats by shuttle-box task had been properly carried out with the criterion of high and low avoidance performance respectively and that 2) HAA rats were predisposed to high anxiety compared with LAA rats. These results indicated that Hatano HAA and LAA rats can be useful models for studying avoidance learning and memory.

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Section: Passive Avoidance Taskmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Male Hatano High-Avoidance Rats Show High Avoidance and High Anxiety-Like Behaviors as Compared with Male Low-Avoidance Rats

et al. 2012

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“…These results cannot be explained by a generalized difference in total activity or anxiety, because there are no effects of IBP exposure on general, anxiety and learning behaviors in female offspring [18]. In contrast, early exposure to IBP increases anxiety, and disturbs passive avoidance performance in male offspring [18].…”

mentioning

confidence: 85%

“…In contrast, early exposure to IBP increases anxiety, and disturbs passive avoidance performance in male offspring [18]. Further elucidation is required for an understanding of the effects of IBP on the male offspring.…”

mentioning

confidence: 99%

Maternal Exposure to Isobutyl-Paraben Impairs Social Recognition in Adult Female Rats

et al. 2010

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Isobutyl-paraben (IBP), a widely used preservative, exhibits estrogenic activity. We analyzed the effects of exposure to IBP during gestation and lactation via dam on social recognition behavior in ovariectomized offspring of Sprague-Dawley rats. Offspring were ovariectomized at 7 weeks of age, and were used in a social recognition test at 16 weeks of age. Each offspring was exposed to a novel ovariectomized rat four times and to a second novel rat in a fifth exposure. We counted the investigations by offspring of intruder rats. The IBP-exposed rats showed impaired social behavior compared with controls. These data imply that early exposure to IBP may have an effect on adult social behavior, which is reported to be an autism spectrum disorders in humans.

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Sublethal exposure to propylparaben leads to lipid metabolism impairment in zebrafish early‐life stages

Perugini

Merola

Amorena

et al. 2019

J of Applied Toxicology

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Parabens are widely used in cosmetics, toiletries, food and pharmaceuticals. Toxicological effects of parabens on human lipid metabolism are not well established. The present study used the early‐life stages of zebrafish (Danio rerio) to determine the toxicity of propylparaben (PP). The embryos were exposed for 96 hours postfertilization (hpf) at five different concentrations of PP, and lethal and sublethal alterations were recorded daily. The lethal concentration 50 (LC50) value was 3.98 mg/L. The most common sublethal alterations recorded at 1 and 2 mg/L were an enlarged and misshaped yolk sac, hyperexcitability, and reduction in head size and swim bladder. At sublethal concentrations of 1 and 2 mg/L, we observed an altered lipid metabolism, in terms of decrease in neutral lipid mobilization from yolk and alteration of phospholipid metabolism, both in the body and in the yolk sac. These observations were combined with strong head cartilage defects, indicating a strong effect of PP on head development. This research demonstrates that PP interferes with lipid utilization in zebrafish during early‐life stages that might be involved in neurological and skeletal abnormalities.

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Maternal isobutyl-paraben exposure alters anxiety and passive avoidance test performance in adult male rats

Cited by 27 publications

References 35 publications

Male Hatano High-Avoidance Rats Show High Avoidance and High Anxiety-Like Behaviors as Compared with Male Low-Avoidance Rats

Male Hatano High-Avoidance Rats Show High Avoidance and High Anxiety-Like Behaviors as Compared with Male Low-Avoidance Rats

Maternal Exposure to Isobutyl-Paraben Impairs Social Recognition in Adult Female Rats

Sublethal exposure to propylparaben leads to lipid metabolism impairment in zebrafish early‐life stages

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