We propose that Clb/Cdc28 kinases prevent pre-RC reassembly in part by promoting the net nuclear export of Mcm proteins. We further propose that Mcm proteins become refractory to this regulation when they load onto chromatin and must be dislodged by DNA replication before they can be exported. Such an arrangement could ensure that Mcm proteins complete their replication function before they are removed from the nucleus.
For almost all Riemannian metrics (in the C ∞ Baire sense) on a closed manifold M n+1 , 3 ≤ (n + 1) ≤ 7, we prove that the union of all closed, smooth, embedded minimal hypersurfaces is dense. This implies there are infinitely many minimal hypersurfaces thus proving a conjecture of Yau (1982) for generic metrics.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.