Maternal influenza during pregnancy and risk of congenital abnormalities in offspring

Ács, Nándor; Bánhidy, Ferenc; Puhó, Erzsébet; Czeizel, Andr̀ew E.

doi:10.1002/bdra.20195

Cited by 183 publications

(65 citation statements)

References 64 publications

(47 reference statements)

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“…Ács and colleagues 10 suggested indirect teratogenic effects of maternal influenza during pregnancy, possibly because of high fever, based on 1 case-control study and the known effects of hyperthermia, which is associated with an increased incidence of neural tube defects. 11 The risk of morbidity from seasonal influenza is higher among pregnant women, 12,13 especially in the third trimester, than among nonpregnant and postpartum women.…”

Section: Influenza-related Complications Pregnancymentioning

confidence: 99%

Safety of neuraminidase inhibitors against novel influenza A (H1N1) in pregnant and breastfeeding women

Tanaka¹,

Nakajima²,

Murashima³

et al. 2009

Canadian Medical Association Journal

144

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Section: Influenza-related Complications Pregnancymentioning

confidence: 99%

Safety of neuraminidase inhibitors against novel influenza A (H1N1) in pregnant and breastfeeding women

Tanaka¹,

Nakajima²,

Murashima³

et al. 2009

Canadian Medical Association Journal

144

View full text Add to dashboard Cite

“…11,12 Maternal influenza illness during pregnancy has also been linked to congenital abnormalities in infants and other adverse pregnancy outcomes. [11][12][13] Pertussis is a serious infection in young infants with the highest hospitalization rates and deaths from pertussis in infants less than 3 months of age. As infants are too young to have received adequate pertussis immunization, reducing transmission from parents is likely to reduce the risk to young infants.…”

Section: Introductionmentioning

confidence: 99%

Increased awareness and health care provider endorsement is required to encourage pregnant women to be vaccinated

Collins

Alona

Tooher

et al. 2014

Human Vaccines & Immunotherapeutics

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Maternal immunization is an important strategy recommended to protect both mothers and infants from serious infectious diseases; however uptake of maternal immunization is poor in Australia. This study aimed to gain an in-depth understanding of the decision making process and factors influencing a pregnant woman's decisions about recommended immunizations. This qualitative study used semi-structured interviews with open-ended questions to interview pregnant women. Data were analyzed using thematic analysis techniques and drew on the Health Belief Model. Pregnant women (n D 17) were asked about their attitudes toward immunization during pregnancy and their perceptions about risk during pregnancy. Women were also asked to detail their decision making process and factors influencing their decisions about immunizations in relation to pregnancy. Most of the participants were not aware of the immunizations recommended during pregnancy, in pregnancy planning or after delivery. In addition to endorsement by their health care provider (HCP), perception of risk and benefit, including risk of infection, previous vaccination experiences and assessing cost benefit play a vital role in women's decisions whether to be immunized while pregnant. Although the role of the healthcare provider in advising pregnant women about immunizations was identified as vitally important, the majority of women had not been advised of recommended vaccines by their healthcare provider. Healthcare providers are key to ensuring pregnant mothers are informed about recommended vaccines and these need to be more proactively supported and encouraged by healthcare providers. This is likely to have a positive effect on acceptance and uptake of immunization by pregnant women.

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“…The signed informed consent was sent back by 98% of mothers, the name and address were deleted in 2% of subjects without signed informed consent. The flow of cases and controls in the HCCSCA was reported previously [26].…”

Section: The Hungarian Case-control Surveillance Of Congenital Abnormmentioning

confidence: 99%

Ventricular septal defects in function of maternal sociodemographic aspects

Vereczkey¹,

Kósa²,

Csáky-Szunyogh

et al. 2012

Open Medicine

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AbstractThe objective of our project is to reveal the possible etiological factors of different congenital cardiovascular abnormalities. In this study, we evaluated single ventricular septal defect (VSD) after surgical correction or with lethal outcome. The birth outcomes of these cases in the function of maternal socio-demographic features were evaluated. Data are based on 1,659 VSD cases, 2,534 matched controls and 38,151 all controls without any defects, in addition in the mothers of 19,393 malformed controls with other isolated defects in the population-based large dataset of the Hungarian Case-Control Surveillance of Congenital Abnormalities. VSD had mild female excess with a higher rate of preterm birth and mainly low birth weight indicating intrauterine growth restriction of affected fetuses, particularly in males and full-term or average weighted cases. The mothers of cases with VSD had lower socioeconomic status and higher rate of smoking and particularly drinking habit. The evaluation of medically recorded pregnancy complications showed an association of gestational diabetes with a higher risk of VSD. In conclusion, the association of small localized size of VDS and obvious fetal growth restriction needs further explanation in these cases, while gestational diabetes, lower socioeconomic status and adverse lifestyle of pregnant women may have a role in the origin of VSD.

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Maternal influenza during pregnancy and risk of congenital abnormalities in offspring

Abstract: The indirect teratogenic effect of maternal influenza during pregnancy may be restricted by appropriate medical treatment (e.g., antifever drugs) and periconceptional folic acid supplementation.

Cited by 183 publications

References 64 publications

Safety of neuraminidase inhibitors against novel influenza A (H1N1) in pregnant and breastfeeding women

Safety of neuraminidase inhibitors against novel influenza A (H1N1) in pregnant and breastfeeding women

Increased awareness and health care provider endorsement is required to encourage pregnant women to be vaccinated

Ventricular septal defects in function of maternal sociodemographic aspects

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