Ventricular septal defects in function of maternal sociodemographic aspects

Vereczkey, Attila; Kósa, Zsolt; Csáky-Szunyogh, Melinda; Czeizel, Andr̀ew E.

doi:10.2478/s11536-012-0024-x

Cited by 6 publications

(6 citation statements)

References 35 publications

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“…The body of literature searched on the subject identified 26 studies which examined SES in relation to CHD development as listed in Table 1. The majority of the studies (18/26, 69%) examined individual maternal SES variables and the risk of CHD [20][21][22][23][24][25][26][27][28][29][30][31][32][33][34][35][36][37], whilst fewer (4/26, 15%) examined associations with SES at the area level or neighborhood level [38][39][40][41], and still others (4/26, 15%) examined the individual, family and neighborhood SES to weigh the relative contribution of each level of the SES variables in CHD development [42][43][44][45].…”

Section: Resultsmentioning

confidence: 99%

The role of socioeconomic status and the development of congenital heart disease: A scoping review

Ngwezi¹,

Hornberger²,

Osornio-Vargas³

2018

apr

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Introduction: Congenital heart disease (CHD) is the most common congenital anomaly affecting 1% of all live births of which the etiology remains unknown. The incidence is higher in developing countries likely related to low literacy, poverty and higher exposures to hazardous environmental nuisances. The role of socioeconomic status (SES) in CHD development has recently received attention. To gain the breadth of knowledge generated from existing publications, we undertook a scoping review of studies examining the relationship between SES and CHD. Methods: We searched databases using individual or combination of keywords which included non-Medical Subject Heading (non-MeSH) and MeSH terms. We included original observational studies using cohort, case control or ecologic study designs written in English and from 1980-2017. Results: We identified 26 studies, most of which were conducted in developed economies with very few from developing economies. The majority (18/26, 69%) examined individual maternal SES variables and the risk of CHD, whilst fewer (4/26, 15%) examined associations with SES at the area level or neighborhood level and others (4/26, 15%) examined the individual, family and neighborhood SES levels to weigh the relative contribution of each SES level in CHD development. Individual maternal low education and low skilled occupation were associated with CHD in half of the studies and another half of the studies found no associations between these variables and CHD. Evidence regarding the influence of neighborhood SES alone or multiple SES variables has been inconclusive as well. Conclusion: There is a paucity of studies from both developed and even more so from developing countries that have examined the influence of SES in CHD development. More knowledge regarding the contribution of various SES measures (i.e., individual, area level, and combinations) on CHD occurrence is required before relevant and effective interventions can be implemented.

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Section: Resultsmentioning

confidence: 99%

The role of socioeconomic status and the development of congenital heart disease: A scoping review

Ngwezi¹,

Hornberger²,

Osornio-Vargas³

2018

apr

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“…31,32 Mothers of newborn infants with a ventricular septal defect have a lower socioeconomic level and a higher percentage of tobacco and alcohol use. 33 When analyzed independently, none of the outcome measures that make up the f-SEL index showed an increased risk for ventricular septal defect.…”

Section: Discussionmentioning

confidence: 99%

Adverse social determinants and risk for congenital anomalies

2014

Arch Argent Pediat

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“…The poor socioeconomic status is associated with lower birth weight in general and e.g. in cases with VSD (Vereczkey et al 2012). However, this effect cannot explain the differences among CHD-entities/groups.…”

Section: Discussionmentioning

confidence: 99%

Birth outcomes of cases with different congenital heart defects - a population-based study

Vereczkey

Gerencsér

Czeizel

et al. 2015

IJH

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Background: In general, previous epidemiological studies evaluated congenital heart defects (CHDs) together. The aim of the present study was to identify possible etiological factors of different CHD-entities, because the underlying causes are unclear in the vast majority of patients.Objectives: Different CHD-entities as homogeneously as possible with confirmed diagnoses were analyzed in the population-based large dataset of the Hungarian Case-Control Surveillance of Congenital Abnormalities.Methods: 3,750 live-born singleton CHD-patients were analyzed according to birth outcomes, i.e. gestational age at delivery and birth weight, the rate of preterm birth, low birthweight and small for gestational age.Results: The major findings of the study showed that cases with different CHD-entities had shorter gestational age at delivery and lower mean birth weight, and these variables associated with a higher rate of preterm birth and particularly with a much higher rate of low birthweight and small for gestational age. This study showed the importance of sex in the birth outcomes of some CHD-entities. The question is why several CHD-entities manifested more frequently in newborns with intrauterine growth restriction because fetal heart has a passive role before birth without pulmonary circulation.Conclusions: The birth outcomes of cases indicate the effect of CHDs for fetal development. In addition maternal confounders have to consider. Finally, CHDs and intrauterine growth restriction as two developmental errors may have a common route, thus fetal growth and birthweight associated gene polymorphisms may have a role in the origin of CHDs.

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Ventricular septal defects in function of maternal sociodemographic aspects

Cited by 6 publications

References 35 publications

The role of socioeconomic status and the development of congenital heart disease: A scoping review

The role of socioeconomic status and the development of congenital heart disease: A scoping review

Adverse social determinants and risk for congenital anomalies

Birth outcomes of cases with different congenital heart defects - a population-based study

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