Maternal influences on the sexual behavior and reproductive success of the female rat

Cameron, Nicole M.; Fish, Eric W.; Meaney, Michael J.

doi:10.1016/j.yhbeh.2008.02.013

Cited by 115 publications

(109 citation statements)

References 40 publications

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“…Although we did not measure sexual behavior in these offspring, given the observed receptor differences in the VMH, it is possible that variations in weaning age may well induce differences in female sexual behavior. Low levels of maternal care experienced during the early postnatal period have previously been associated with increased lordosis quotients of female offspring corresponding to altered hypothalamic estro-gen receptor (ER) expression [Cameron et al, 2008a;Cameron et al, 2008b]. In males, the VMH is critical in the regulation of sexual and aggressive behaviors primarily through the actions of estrogen on ER ␣ [Harding and McGinnis, 2004;Nelson and Trainor, 2007].…”

Section: Neurobiological Changes Associated With Weaning Age: Plasticmentioning

confidence: 99%

The Meaning of Weaning: Influence of the Weaning Period on Behavioral Development in Mice

et al. 2009

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Maternal care during the first week postpartum has long-term consequences for offspring development in rodents. However, mother-infant interactions continue well beyond this period, with several physiological and behavioral changes occurring between days 18 and 28 PN. In the present study, we investigate the long-term effects on offspring behavior of being weaned at day 21 PN versus day 28 PN. We found that male and female offspring engage in higher initial levels of social interaction if weaned at day 28 PN, as well as sexually dimorphic changes in exploratory behavior. Females who were themselves weaned earlier also appeared to wean their own pups earlier. Sex-specific effects of weaning age were found on levels of oxytocin and vasopressin V1a receptor density in the hypothalamus, central nucleus of the amygdala and nucleus accumbens. These results indicate that altering weaning age in mice may be a useful model for investigating the development of sexual dimorphism in neurobiology and behavior.

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Section: Neurobiological Changes Associated With Weaning Age: Plasticmentioning

confidence: 99%

The Meaning of Weaning: Influence of the Weaning Period on Behavioral Development in Mice

et al. 2009

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“…The evidence linking early-life environment to reproductive timing in humans is necessarily correlational (though see [11] for a natural experiment). However, there are genuinely experimental non-human systems that have provided evidence of similar effects [12][13][14][15].…”

Section: Introductionmentioning

confidence: 99%

The evolution of predictive adaptive responses in human life history

2013

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Many studies in humans have shown that adverse experience in early life is associated with accelerated reproductive timing, and there is comparative evidence for similar effects in other animals. There are two different classes of adaptive explanation for associations between early-life adversity and accelerated reproduction, both based on the idea of predictive adaptive responses (PARs). According to external PAR hypotheses, early-life adversity provides a 'weather forecast' of the environmental conditions into which the individual will mature, and it is adaptive for the individual to develop an appropriate phenotype for this anticipated environment. In internal PAR hypotheses, early-life adversity has a lasting negative impact on the individual's somatic state, such that her health is likely to fail more rapidly as she gets older, and there is an advantage to adjusting her reproductive schedule accordingly. We use a model of fluctuating environments to derive evolveability conditions for acceleration of reproductive timing in response to early-life adversity in a long-lived organism. For acceleration to evolve via the external PAR process, early-life cues must have a high degree of validity and the level of annual autocorrelation in the individual's environment must be almost perfect. For acceleration to evolve via the internal PAR process requires that early-life experience must determine a significant fraction of the variance in survival prospects in adulthood. The two processes are not mutually exclusive, and mechanisms for calibrating reproductive timing on the basis of early experience could evolve through a combination of the predictive value of early-life adversity for the later environment and its negative impact on somatic state.

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“…The most pronounced effect occurs in female rats compared to males (CAMERON et al, 2008;WALKER et al, 2011;SOMINSKY et al, 2012).…”

Section: Introductionmentioning

confidence: 92%

Maternal periodontitis induces intergenerational injuries on reproductive performance of adult female rat offspring

Pimentel

Casati

Cirano

et al. 2017

Braz. J. Vet. Res. Anim. Sci.

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Substantial evidence suggests a direct link between periodontitis in pregnant women and subsequent adverse pregnancy outcomes. However, no studies have evaluated the transgenerational effects of periodontitis on the reproductive performance of subsequent generations. The present study investigated whether maternal periodontal disease exerts deleterious transgenerational effects on reproductive performance in F1 female rats. Rat female offspring from mothers that were subjected to experimentally induced periodontitis or sham operation were mated with sexually experienced male rats. The weight and reproductive performance of these F1 offspring were evaluated on gestation day 21, including maternal weight, litter weight, individual pup weight, number of pups, and number of resorptions. The percentage of dams with resorptions and the litter weight/number of pups were also calculated. Compared with the control group, an increase was observed in the percentage and number of resorptions and litter weight/number of pups, and a decrease was observed in the number of pups born in the experimental group. Maternal weight, litter weight, and individual pup weight were not different between the control and experimental groups. Maternal periodontitis impaired reproductive performance in the F1 generation. We showed that periodontitis may induce reproductive injury in adult offspring even if the offspring do not undergo any inflammatory/infectious process during their postnatal life or during gestation. These findings reinforce the importance of oral care during pregnancy. Keywords: Maternal immune activation. Reproduction. Intergenerational effect. Periodontitis. Rat. ResumoExistem evidências substanciais de uma relação direta entre periodontite em mulheres grávidas com efeitos adversos reprodutivos. No entanto, nenhum estudo avaliou os efeitos intergeracionais da periodontite sobre o desempenho reprodutivo das gerações subsequentes. O presente estudo investigou se a doença periodontal materna exerce efeitos intergeracionais deletérios sobre o desempenho reprodutivo em ratos fêmeas da geração F1. Assim, filhas de ratas cujas mães foram submetidas a periodontite experimental ou falsamente operadas foram acasaladas com ratos machos sexualmente experientes. O peso corporal e desempenho reprodutivo da geração F1 foram avaliados no dia 21 de gestação, incluindo o peso materno, peso da ninhada, peso da individual dos filhotes, número de filhotes e de reabsorções. A percentagem de fêmeas com reabsorção e o peso da ninhada/número de filhotes também foram calculados. Comparados com o grupo controle, observou-se aumento na porcentagem e número de reabsorções e no peso da ninhada/ número de filhotes, e decréscimo no número de filhotes nascidos no grupo experimental. O peso materno, peso da ninhada e individual dos filhotes não foi diferente entre o controle e experimental. Estes resultados mostram que a periodontite experimental materna prejudica o desempenho reprodutivo da geração F1, mesmo que estes animais não tenham sido expo...

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Maternal influences on the sexual behavior and reproductive success of the female rat

Cited by 115 publications

References 40 publications

The Meaning of Weaning: Influence of the Weaning Period on Behavioral Development in Mice

The Meaning of Weaning: Influence of the Weaning Period on Behavioral Development in Mice

The evolution of predictive adaptive responses in human life history

Maternal periodontitis induces intergenerational injuries on reproductive performance of adult female rat offspring

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