Maternal High‐Fat‐Diet Programs Rat Offspring Liver Fatty Acid Metabolism

Seet, Emily; Yee, Jennifer K.; Jellyman, Juanita K.; Han, Guang; Ross, Michael G.; Desai, Mina

doi:10.1007/s11745-015-4018-8

Cited by 37 publications

(34 citation statements)

References 40 publications

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“…51 a,b LEM, Flard70YABWMarco A. 52D:\preeditjobs\Springernature\Scirep\5344\reprogrammed - MEP_L_bib52 WFlard100YABW, LEPLecoutre S. 53 a,b WM, Flard154AFAT, BW, LEP, GLU, INS, TGAmbrosetti V. 54 a SDFlard na PPPBW, INSAmbrosetti V. 54 b SDFlard na YABWGuberman C. 55 a,b SDMlard98, 77YABW, SBPSeet E.L. 56 SDMlard98YATGDesai M. 57 a,c SDM, Flard98PPPSBPDesai M. 57 b,d SDM, Flard98YAFAT, BW, LEP, GLU, INS, TGDesai M. 57 e,g SDM, Flard77PPPSBPDesai M. 57 f,h SDM, Flard77YAFAT, BW, LEP, GLU, INS, TGDesai M. 58 SDMlard98AFAT, BW, GLU, INS, TGWalker C.D. 59 a SDMlard28PPPFAT, INSWalker C.D.…”

Section: Resultsmentioning

confidence: 99%

The Association between High Fat Diet around Gestation and Metabolic Syndrome-related Phenotypes in Rats: A Systematic Review and Meta-Analysis

Tellechea

Mensegue

Pirola

2017

Sci Rep

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Numerous rodent studies have evaluated the effects of a maternal high-fat diet (HFD) on later in life susceptibility to Metabolic Syndrome (MetS) with varying results. Our aim was to quantitatively synthesize the available data on effects of maternal HFD around gestation on offspring’s body mass, body fat, plasma leptin, glucose, insulin, lipids and systolic blood pressure (SBP). Literature was screened and summary estimates of the effect of maternal HFD on outcomes were calculated by using fixed- or random-effects models. 362 effect sizes from 68 studies together with relevant moderators were collected. We found that maternal HFD is statistically associated with higher body fat, body weight, leptin, glucose, insulin and triglycerides levels, together with increased SBP in offspring later in life. Our analysis also revealed non-significant overall effect on offspring’s HDL-cholesterol. A main source of variation among studies emerged from rat strain and lard-based diet type. Strain and sex -specific effects on particular data subsets were detected. Recommendations are suggested for future research in the field of developmental programming of the MetS. Despite significant heterogeneity, our meta-analysis confirms that maternal HFD had long-term metabolic effects in offspring.

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Section: Resultsmentioning

confidence: 99%

The Association between High Fat Diet around Gestation and Metabolic Syndrome-related Phenotypes in Rats: A Systematic Review and Meta-Analysis

Tellechea

Mensegue

Pirola

2017

Sci Rep

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“…) and in 6‐month‐old offspring exposed to a high‐fat diet during both the fetal and suckling periods (Seet et al . ).…”

Section: Discussionmentioning

confidence: 97%

Impact of perinatal exposure to sucrose or high fructose corn syrup (HFCS‐55) on adiposity and hepatic lipid composition in rat offspring

Toop

Mühlhäusler

O’Dea

et al. 2017

The Journal of Physiology

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Key pointsr Fructose-containing sugars, including sucrose and high fructose corn syrup (HFCS), have been implicated in the epidemics of obesity and type 2 diabetes.r Few studies have evaluated the impact of perinatal exposure to these sugars on metabolic and physiological outcomes in the offspring.r Using a rat model, offspring exposed to a maternal sucrose or HFCS diet during the prenatal and/or suckling periods were found to have altered adiposity and liver fat content and composition at weaning.r Plasma levels of free fatty acids remained elevated in young adulthood, but consumption of a control diet following weaning appeared to ameliorate most other effects of perinatal exposure to a maternal high-sugar diet.r Guidelines for maternal nutrition should advise limiting consumption of fructose-containing sugars, and it is particularly important that these recommendations include maternal nutrition during lactation.Abstract Perinatal exposure to excess maternal intake of added sugars, including fructose and sucrose, is associated with an increased risk of obesity and type 2 diabetes in adult life. However, it is unknown to what extent the type of sugar and the timing of exposure affect these outcomes. The aim of this study was to determine the impact of exposure to maternal consumption of a 10% (w/v) beverage containing sucrose or high fructose corn syrup-55 (HFCS-55) during the prenatal and/or suckling periods on offspring at 3 and 12 weeks, utilising a cross-fostering approach in a rodent model. Perinatal sucrose exposure decreased plasma glucose concentrations in offspring at 3 weeks, but did not alter glucose tolerance. Increased adiposity was observed in 3-week-old offspring exposed to sucrose or HFCS-55 during suckling, with increased hepatic fat content in HFCS-55-exposed offspring. In terms of specific fatty acids, hepatic monounsaturated (omega-7 and -9) fatty acid content was elevated at weaning, and was most pronounced in sucrose offspring exposed during both the prenatal and suckling periods, and HFCS-55 offspring exposed during suckling only. By 12 weeks, the effects on adiposity and hepatic lipid composition were largely normalised. However, exposure to either sucrose or HFCS-55 during the prenatal period only was associated with elevated plasma free fatty acids at weaning, and this effect persisted until 12 weeks. This study suggests that the type of sugar and the timing of exposure (prenatal or suckling periods) are both important for determining the impact on metabolic health outcomes in the offspring.

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“…The impact of environmental influences during early life on developmental programming of diseases in adulthood has been previously demonstrated in both human and animal studies (Barker et al 2002; Ronco et al 2011) and is linked to numerous conditions including obesity, type-2 diabetes, and hypertension (Barker 1997). During the last decade, much of the emphasis in developmental programming research has been placed on the impact of nutritional insults, endocrine disruptors, and pesticides during pregnancy (Manikkam et al 2012; Seet et al 2015). Less attention has been placed on in utero developmental programming effects of exposure to environmental contaminants such as heavy metals, cadmium (Cd) and mercury (Hg).…”

Section: Introductionmentioning

confidence: 99%

Effects of Periconception Cadmium and Mercury Co-Administration to Mice on Indices of Chronic Diseases in Male Offspring at Maturity

Çamsarı

Folger

McGee

et al. 2017

Environ Health Perspect

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Background:Long-term exposure to the heavy metals cadmium (Cd) and mercury (Hg) is known to increase the risk of chronic diseases. However, to our knowledge, exposure to Cd and Hg beginning at the periconception period has not been studied to date.Objective:We examined the effect of Cd and Hg that were co-administered during early development on indices of chronic diseases in adult male mice.Methods:Adult female CD1 mice were subcutaneously administered a combination of cadmium chloride (CdCl2) and methylmercury (II) chloride (CH3HgCl) (0, 0.125, 0.5, or 2.0 mg/kg body weight each) 4 days before and 4 days after conception (8 days total). Indices of anxiety-like behavior, glucose homeostasis, endocrine and molecular markers of insulin resistance, and organ weights were examined in adult male offspring.Results:Increased anxiety-like behavior, impaired glucose homeostasis, and higher body weight and abdominal adipose tissue weight were observed in male offspring of treated females compared with controls. Significantly increased serum leptin and insulin concentrations and impaired insulin tolerance in the male offspring of dams treated with 2.0 mg/kg body weight of Cd and Hg suggested insulin resistance. Altered mRNA abundance for genes associated with glucose and lipid homeostasis (GLUT4, IRS1, FASN, ACACA, FATP2, CD36, and G6PC) in liver and abdominal adipose tissues as well as increased IRS1 phosphorylation in liver (Ser 307) provided further evidence of insulin resistance.Conclusions:Results suggest that the co-administration of Cd and Hg to female mice during the early development of their offspring (the periconception period) was associated with anxiety-like behavior, altered glucose metabolism, and insulin resistance in male offspring at adulthood.Citation:Camsari C, Folger JK, McGee D, Bursian SJ, Wang H, Knott JG, Smith GW. 2017. Effects of periconception cadmium and mercury co-administration to mice on indices of chronic diseases in male offspring at maturity. Environ Health Perspect 125:643–650; http://dx.doi.org/10.1289/EHP481

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Maternal High‐Fat‐Diet Programs Rat Offspring Liver Fatty Acid Metabolism

Cited by 37 publications

References 40 publications

The Association between High Fat Diet around Gestation and Metabolic Syndrome-related Phenotypes in Rats: A Systematic Review and Meta-Analysis

The Association between High Fat Diet around Gestation and Metabolic Syndrome-related Phenotypes in Rats: A Systematic Review and Meta-Analysis

Impact of perinatal exposure to sucrose or high fructose corn syrup (HFCS‐55) on adiposity and hepatic lipid composition in rat offspring

Effects of Periconception Cadmium and Mercury Co-Administration to Mice on Indices of Chronic Diseases in Male Offspring at Maturity

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