Maternal high‐fat diet consumption enhances offspring susceptibility to DSS‐induced colitis in mice

Bibi, Shahida; Kang, Yifei; Du, Min; Zhu, Mei‐Jun

doi:10.1002/oby.21816

Cited by 32 publications

(27 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…94 This phenotype was associated with increased neutrophil infiltration in the gut, paralleled with higher Ccl2 transcripts. 94 A sheep model of maternal obesity reported similar changes in the fetal gut as early as the second trimester, with increased expression of monocyte/macrophage genes TNF, IL1B, IL6, IL8, CCL2, CD68, ITGAM (encoding CD11b), and CD14 in fetal large intestine. 95 Furthermore, both mRNA and protein levels of TGF-were elevated in gut tissue obtained from offspring of obese ewes.…”

Section: Maternal Obesity and Immune Homeostasis In Nonlymphoid Tissumentioning

confidence: 96%

“…Specifically, rodent studies have reported enhanced susceptibility to DSS‐induced colitis in the offspring that was accompanied by up‐regulation of NF‐κB signaling and expression of Il1b , Il6 , and Il17 genes . This phenotype was associated with increased neutrophil infiltration in the gut, paralleled with higher Ccl2 transcripts . A sheep model of maternal obesity reported similar changes in the fetal gut as early as the second trimester, with increased expression of monocyte/macrophage genes TNF , IL1B , IL6 , IL8 , CCL2 , CD68 , ITGAM (encoding CD11b), and CD14 in fetal large intestine .…”

Section: Introductionmentioning

confidence: 99%

“…In addition to the liver and spleen, exposure to HFD during gestation alters inflammatory responses in the fetal gut. Specifically, rodent studies have reported enhanced susceptibility to DSS‐induced colitis in the offspring that was accompanied by up‐regulation of NF‐κB signaling and expression of Il1b , Il6 , and Il17 genes . This phenotype was associated with increased neutrophil infiltration in the gut, paralleled with higher Ccl2 transcripts .…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Impact of pregravid obesity on maternal and fetal immunity: Fertile grounds for reprogramming

Sureshchandra

Marshall

Messaoudi

2019

Journal of Leukocyte Biology

View full text Add to dashboard Cite

Maternal pregravid obesity results in several adverse health outcomes during pregnancy, including increased risk of gestational diabetes, preeclampsia, placental abruption, and complications at delivery. Additionally, pregravid obesity and in utero exposure to high fat diet have been shown to have detrimental effects on fetal programming, predisposing the offspring to adverse cardiometabolic, endocrine, and neurodevelopmental outcomes. More recently, a deeper appreciation for the modulation of offspring immunity and infectious disease‐related outcomes by maternal pregravid obesity has emerged. This review will describe currently available animal models for studying the impact of maternal pregravid obesity on fetal immunity and review the data from clinical and animal model studies. We also examine the burden of pregravid obesity on the maternal–fetal interface and the link between placental and systemic inflammation. Finally, we discuss future studies needed to identify key mechanistic underpinnings that link maternal inflammatory changes and fetal cellular reprogramming events.

show abstract

Section: Maternal Obesity and Immune Homeostasis In Nonlymphoid Tissumentioning

confidence: 96%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Impact of pregravid obesity on maternal and fetal immunity: Fertile grounds for reprogramming

Sureshchandra

Marshall

Messaoudi

2019

Journal of Leukocyte Biology

View full text Add to dashboard Cite

show abstract

“…47 Maternal high-fat diet enhanced offspring susceptibility to DSSinduced colitis, increased inflammatory cytokine IL-1β, IL-6 and IL-17, and amplified NF-кB inflammatory signaling response in mice, which was associated with suppressed AMPK phosphorylation. 102 Interestingly, in IL-10-deficient mice, AMPK phosphorylation is elevated, which could be due to energy dysregulation associated with chronic inflammation and oxidative stress; consistently, grape seed extract enriched with polyphenolic compounds prevented inflammation, and restored AMPK activity and barrier function in these mice. 96 In summary, AMPK improves gut epithelial barrier function through promoting oxidative metabolism and suppressing inflammation.…”

Section: Ampk In Epithelial Differentiation Inflammation and Barriermentioning

confidence: 99%

AMPK in regulation of apical junctions and barrier function of intestinal epithelium

Zhu

Sun

2018

Tissue Barriers

Self Cite

View full text Add to dashboard Cite

Gut epithelium covers the inner layer of the gastrointestinal tract and provides a physical barrier to separate the host from its external environment, and its barrier function is critical for maintaining host health. AMP-activated protein kinase (AMPK) as a master regulator of energy metabolism plays a critical role in epithelial barrier function. AMPK activation promotes epithelial differentiation and facilitates cell polarity establishment, both of which strengthen epithelial barrier. In addition, AMPK promotes the assembly of tight junctions and adherens junctions by direct phosphorylation of proteins composing apical junctions, junctional anchors, and cytoskeletons. Pharmacological and nutraceutical compounds, as well as physiological states triggering AMPK activation strengthen epithelial barrier function. This review summarized recent progress in delineating the regulatory roles of AMPK in apical junction formation and barrier function of intestinal epithelium.

show abstract

“…After feeding distilled water for one week, all other mice except for the normal group received 4% (w/v) DSS solution as drinking water during the fifth week. Except for the third and fifth weeks, all mice received distilled water as drinking water for the rest of the time [16,17]. During the entire experimental duration of five weeks, the SDC-L and SDC-H groups received 2 and 4 g/kg of extract of Shuidouchi daily after the optimization of crafts.…”

Section: Animal Experimentsmentioning

confidence: 99%

Process Design of the Antioxidant Shuidouchi and Its Effect on Preventing Dextran Sulfate Sodium (DSS)-Induced Colitis in Mice via Antioxidant Activity

Zhang

Yang

et al. 2018

Applied Sciences

View full text Add to dashboard Cite

Shuidouchi is a traditionally fermented soybean product in China. Shuidouchi production requires a variety of processes; however, the production process has not been standardized. It can be developed into high-quality products with enhanced health effects by improving the design of its fermentation process and increasing the content of its active ingredients. In this study, a single-factor experiment was conducted that established different process conditions to determine the fermentation conditions that achieve the highest content of active ingredients and the best in vitro antioxidant effect. The effect of Shuidouchi on the prevention of dextran sulfate sodium-induced colitis in mice was also observed. The obtained results indicated that the optimal process conditions involved soaking for 12 h, placement in a glass container, and fermentation at 35 • C for 48 h. Shuidouchi that was fermented under such conditions had the highest level of soybean isoflavones and exerted greater antioxidant effects than if fermented under other conditions. The Shuidouchi extract (soaking twice the quantity of water for 12 h, placing in a glass container, and fermenting at 35 • C for 48 h) obtained by using the optimal fermentation process can prevent the shortening of the colon and increase the weight-to-length ratio of the colon that is caused by colitis. Shuidouchi extraction not only effectively reduces the disease activity index and the levels of serum endothelin (ET), substance P (SP), and interleukin-10 (IL-10), it also increases the levels of somatostatin (SS), vasoactive intestinal peptide (VIP), and interleukin-2 (IL-2) of mice with colitis. In addition, Shuidouchi extraction increased the levels of glutathione (GSH) and superoxide dismutase (SOD) in colitis mice; in contrast, Shuidouchi decreased the levels of myeloperoxidase (MPO) and malondialdehyde (MDA) in the colon of mice with colitis. Further detection of mRNA in colon tissues showed that Shuidouchi extraction can upregulate the expression of neuronal nitric oxide synthase (nNOS), endothelial nitric oxide synthase (eNOS), c-Kit, and the stem cell factor (SCF). Furthermore, it can downregulate the expression of inducible nitric oxide synthase (iNOS), interleukin-8 (IL-8), and C-X-C chemokine receptor type 2 (CXCR2) in the colon of mice with colitis. Further experimental results showed that Shuidouchi could reduce the protein expression of interleukin 6 (IL-6), IL-12, and tumor necrosis factor-α (TNF-α) in colitic mice. Therefore, the improved processing of Shuidouchi inhibits colitis, which is directly related to the high content of soybean isoflavones.

show abstract

Maternal high‐fat diet consumption enhances offspring susceptibility to DSS‐induced colitis in mice

Abstract: Maternal HFD consumption predisposes offspring to a higher susceptibility to develop inflammatory bowel disease.

Cited by 32 publications

References 39 publications

Impact of pregravid obesity on maternal and fetal immunity: Fertile grounds for reprogramming

Impact of pregravid obesity on maternal and fetal immunity: Fertile grounds for reprogramming

AMPK in regulation of apical junctions and barrier function of intestinal epithelium

Process Design of the Antioxidant Shuidouchi and Its Effect on Preventing Dextran Sulfate Sodium (DSS)-Induced Colitis in Mice via Antioxidant Activity

Contact Info

Product

Resources

About