Maternal haemoglobin level at booking visit and its effect on adverse pregnancy outcome

Abeysena, Chrishantha; Jayawardana, Pushpa; Seneviratne, Rohini De Alwis

doi:10.1111/j.1479-828x.2010.01220.x

Cited by 50 publications

(62 citation statements)

References 16 publications

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“…This suggested that hemoglobin effects in developing countries ( n = 9 studies) [9–12, 16, 17, 28, 32, 34] were similar to the overall effects with the pooled ORs of 1.69 (95% CI: 1.28–2.23), 1.34 (95% CI: 1.17–1.53), 1.10 (95% CI: 1.02–1.19), and 0.93 (95% CI: 0.80–1.08) for hemoglobin cutoffs <9, <10, <11, and ≥14 g/dL, respectively. However, the hemoglobin effects were lower and nonsignificant in developed countries ( n = 2 studies) [18, 27] compared with developing countries with the pooled ORs of 1.17 (95% CI: 0.47–2.93) and 1.21 (95% CI: 0.59–2.51) for the cutoffs of <10 and <11 g/dL, respectively.…”

Section: Resultsmentioning

confidence: 99%

“…Ten studies [9–12, 17, 27, 28, 31, 32, 34] assessed the association between low hemoglobin concentration in the first trimester and LBW with hemoglobin concentration ranging from 7 to 16 g/dL (Supplementary Table 3). Nine studies [9–12, 17, 28, 31, 32, 34] were conducted in developing countries.…”

Section: Resultsmentioning

confidence: 99%

“…Some studies found significant associations [6–12], while other studies did not [13–16]; this is likely the result of different studies using different criteria or cutoff thresholds for defining anemia. In another way, some studies reported the association between high hemoglobin concentration and adverse pregnancy outcomes [17, 18]. Although a previous systematic review published in 2000 [19] reported maternal anemia in early pregnancy (<20 gestational week) increased the risk of PTB but not for LBW and SGA.…”

Section: Introductionmentioning

confidence: 99%

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Hemoglobin Concentration and Pregnancy Outcomes: A Systematic Review and Meta-Analysis

Sukrat

Wilasrusmee

Siribumrungwong

et al. 2013

BioMed Research International

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Objective. To conduct a systematic review and meta-analysis of hemoglobin effect on the pregnancy outcomes. Methods. We searched MEDLINE and SCOPUS from January 1, 1990 to April 10, 2011. Observational studies addressing association between hemoglobin and adverse pregnancy outcomes were selected. Two reviewers independently extracted data. A mixed logistic regression was applied to assess the effects of hemoglobin on preterm birth, low birth weight, and small for gestational age. Results. Seventeen studies were included in poolings. Hemoglobin below 11 g/dL was, respectively, 1.10 (95% CI: 1.02–1.19), 1.17 (95% CI: 1.03–1.32), and 1.14 (95% CI: 1.05–1.24) times higher risk of preterm birth, low birth weight, and small for gestational age than normal hemoglobin in the first trimester. In the third trimester, hemoglobin below 11 g/dL was 1.30 (95% CI: 1.08–1.58) times higher risk of low birth weight. Hemoglobin above 14 g/dL in third trimester decreased the risk of preterm term with ORs of 0.50 (95% CI: 0.26–0.97), but it might be affected by publication bias. Conclusions. Our review suggests that hemoglobin below 11 g/dl increases the risk of preterm birth, low birth weight, and small gestational age in the first trimester and the risk of low birth weight in the third trimester.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Hemoglobin Concentration and Pregnancy Outcomes: A Systematic Review and Meta-Analysis

Sukrat

Wilasrusmee

Siribumrungwong

et al. 2013

BioMed Research International

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“…In Sri Lanka, 5% -7% of the population have the Rh-Negative Blood group. This study also shows that 6.3% had Rh Negative blood group which is similar na- In Sri Lanka Syphilis (all forms of syphilis) constituted 10% of sexually transmitted infections in 2016 [15]. Overall 98.1% of pregnant mothers were tested for VDRL in Sri Lanka at the time of delivery.…”

Section: Discussionmentioning

confidence: 57%

Hitches in Antenatal Screening in Vaharai, Batticaloa, Sri Lanka

Thirukumar¹

2018

OJOG

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Women in developing countries are at more risk for pregnancy-related complications than their counterpart of developed countries. However, many of the complications are preventable with good quality antenatal care (ANC). This descriptive cross-sectional study was conducted among all the pregnant mothers who attend to routine antenatal clinic for booking visit at Vaharai, Batticaloa district of Sri Lanka during the time periods of 2015-2016. This study included 695 pregnant mothers. Among them majority were (n = 661; 95.1%) Tamil and belong to (n = 587; 84.5%) average age of 19 to 35 years. Majority of pregnant mothers studied up to grade eleven (GCE O/L) (n = 484; 69.6%). Among them 14.4% were identified as anaemic. Among anaemic mothers 8.4% were mild, 5.2% were moderate & 0.8% severe anaemic. There was no statistically significant difference between ethnicity, parity of pregnant mothers, & their respective haemoglobin levels. Most pregnant mothers belong to (n = 338; 48.6%) blood group O and majority were Rh positive (n = 603; 86.8%). 90.6% of pregnant mothers underwent VDRL test and none was positive. This study shows that about 15% of first trimester pregnant mothers were anemic. Nutritional interventions for pre-pregnant women and educating pregnant women on prevention of anaemia, are recommended. Measures must also be taken to decrease teen age marriages.

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“…37,38 Hence, whether the disordered maternal hemoglobin levels during pregnancy affect adverse birth outcomes is still in controversy. In healthy pregnant women, the lack of an increase in plasma volume during pregnancy is associated with lower birth weight and placental weight and an increased risk of delivering a small-for-gestational-age infant.…”

Section: Discussionmentioning

confidence: 99%

RNA-Seq-Based Transcriptome Analysis of Changes in Gene Expression Linked to Human Pregnancy Outcome After In Vitro Fertilization—Embryo Transfer

Zhang

et al. 2016

Reprod. Sci.

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To promote the pregnancy rate of in vitro fertilization-embryo transfer (IVF-ET), we proposed to examine the differentially expressed gene during pregnancy success and failure. We used high-sequencing technology to characterize and compare the gene expression profiles of pregnancy success and pregnancy failure patients during 3 different stages: before IVF-ET (stage I), after ovarian stimulation (stage II), and day 15 after embryo transfer (stage III). Selected data from RNA-sequencing experiments were validated by quantitative real-time polymerase chain reaction (qRT-PCR). A total of 282, 208, and 372 genes in stages I, II, and III, respectively, were differentially expressed between pregnancy success and pregnancy failure, respectively. Through confirmation with qRT-PCR, compared to pregnancy failure, we demonstrated much lower level of major histocompatibility complex, human leukocyte antigen class I A, and an much higher level of human leukocyte antigen, class II DQ α1 (HLA-DQA1) in pregnancy success, although the HLA-DQA1 decreased with development duration of pregnancy. Interleukin 1β increased with the development duration of pregnancy in pregnancy failure group and was much higher than that in pregnancy success group. Hemoglobin δ decreased with the development duration of pregnancy in pregnancy failure women and maintained in a lower level in stage I and II but dramatically increased to a much higher level in stage III in pregnancy success women. Minichromosome maintenance complex component 4 significantly increased in stage III in pregnancy failure but not in pregnancy success women. The altered expression of genes implicated in immune response and inflammation, oocyte meiosis, rhythmic process, and so on. Therefore, the current results provide a strong basis for future research to expound the molecular mechanism coping with pregnancy outcome.

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Maternal haemoglobin level at booking visit and its effect on adverse pregnancy outcome

Abstract: Although anaemia during pregnancy was not adversely associated with any of the pregnancy outcomes, Hb level of >13.9 g/dL was adversely associated with maternal morbidities and LBW.

Cited by 50 publications

References 16 publications

Hemoglobin Concentration and Pregnancy Outcomes: A Systematic Review and Meta-Analysis

Hemoglobin Concentration and Pregnancy Outcomes: A Systematic Review and Meta-Analysis

Hitches in Antenatal Screening in Vaharai, Batticaloa, Sri Lanka

RNA-Seq-Based Transcriptome Analysis of Changes in Gene Expression Linked to Human Pregnancy Outcome After In Vitro Fertilization—Embryo Transfer

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