Maternal gestational diabetes and childhood obesity at age 9–11: results of a multinational study

Zhao, Pei; Liu, Enqing; Qiao, Yijuan; Katzmarzyk, Peter T.; Chaput, Jean‐Philippe; Fogelholm, Mikael; Johnson, William D.; Kuriyan, Rebecca; Kurpad, Anura; Lambert, Estelle V.; Maher, Carol; Maia, José; Matsudo, Victor Keihan Rodrigues; Olds, Tim; Onywera, Vincent; Sarmiento, Olga L.; Standage, Martyn; Tremblay, Mark S.; Tudor–Locke, Catrine; Hu, Gang

doi:10.1007/s00125-016-4062-9

Cited by 100 publications

(96 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…On the other hand, maternal fasting plasma glucose concentration during pregnancy was associated with overweight of the offspring at the age of 7 years in 1 longitudinal study [25]. A large multinational study on the association of maternal GDM with childhood obesity at the age of 9–11 years indicated that childhood obesity may partly be linked to current maternal BMI [26]. Thus, all in all, exposure to maternal GDM seems to have only a minimal effect on the weight status of the offspring at prepuberty.…”

Section: Discussionmentioning

confidence: 99%

Prepubertal Children Exposed to Maternal Gestational Diabetes Have Latent Low-Grade Inflammation

et al. 2018

View full text Add to dashboard Cite

Background: Maternal gestational diabetes mellitus (GDM) and overweight are associated with an increased risk of obesity and the metabolic syndrome in the adult offspring. We studied the influence of maternal GDM on prepubertal children’s height, weight, body mass index (BMI), lipid and glucose metabolism, and low-grade inflammation. Methods: A cohort of 135 prepubertal Caucasian children (age range 4.4–9.7 years) was studied in a controlled cross-sectional study. Seventy-seven children had been exposed to maternal GDM, and 58 children born after a normal pregnancy served as controls. The outcomes were height, weight, BMI, blood pressure, and biochemical markers of glucose and lipid metabolism and inflammation. Results: There were no differences in height, weight, BMI, fasting serum insulin, plasma glucose, lipids, or blood pressure between the study groups. However, high-sensitivity C-reactive protein (hs-CRP) was significantly higher in the GDM group than in the controls (p = 0.001). Conclusions: Higher hs-CRP as a marker of low-grade inflammation was detected in prepubertal children exposed to maternal GDM, but no differences were seen in height, weight, BMI, or markers of glucose and lipid metabolism compared to control children. This finding may reflect an ongoing process of metabolic changes in children born after a GDM pregnancy.

show abstract

Section: Discussionmentioning

confidence: 99%

Prepubertal Children Exposed to Maternal Gestational Diabetes Have Latent Low-Grade Inflammation

et al. 2018

View full text Add to dashboard Cite

show abstract

“…Moreover, GDM diagnosis is associated with increased future risk of obesity, cardiovascular disease and metabolic disease in both mother and child (Zhao et al 2016; Stang and Huffman, 2016). As discussed above, maternal meta-inflammation (elevated IL-6, leptin and low adiponectin) may stimulate placental nutrient transport in pregnancies complicated by obesity with GDM contributing to fetal overgrowth (Segovia et al 2014).…”

Section: Obstetric Complications Associated With Maternal Obesitymentioning

confidence: 99%

Effects of maternal obesity on placental function and fetal development

2017

View full text Add to dashboard Cite

Obesity has reached epidemic proportions and pregnancies in obese mothers have increased risk for complications including gestational diabetes, hypertensive disorders, preterm birth and caesarian section. Children born to obese mothers are at increased risk of obesity and metabolic disease and are susceptible to develop neuropsychiatric and cognitive disorders. Changes in placental function not only play a critical role in the development of pregnancy complications but may also be involved in linking maternal obesity to long-term health risks in the infant. Maternal adipokines i.e., interleukin 6 (IL-6), tumor necrosis factor alpha (TNF-α), leptin and adiponectin link maternal nutritional status and adipose tissue metabolism to placental function. Adipokines and metabolic hormones have direct impact on placental function by modulating placental nutrient transport. Nutrient delivery to the fetus is regulated by a complex interaction between insulin signaling, cytokine profile and insulin responsiveness, which is modulated by adiponectin and IL-1β. In addition, obese pregnant women are at risk for hypertension and preeclampsia with reduced placental vascularity and blood flow, which would restrict placental nutrient delivery to the developing fetus. These sometimes opposing signals regulating placental function may contribute to the diversity of short and long-term outcomes observed in pregnant obese women. This review focuses on the changes in adipokines and obesity-related metabolic hormones, how these factors influence placental function and fetal development to contribute to long-term metabolic and behavioral consequences of children born to obese mothers.

show abstract

“…Development of type 2 diabetes occurs in more than 50% of women with GDM during 5–10 years after delivery . In addition, there is an elevated risk of obesity, diabetes and the metabolic syndrome in the offspring of women that are affected with GDM . Several risk factors play role in GDM development including maternal age, obesity, race, previous history of foetal macrosomia and family history of T2DM .…”

Section: Introductionmentioning

confidence: 99%

The relationship between pre‐pregnancy dietary patterns adherence and risk of gestational diabetes mellitus in Iran: A case–control study

Asadi

Shahzeidi

Nadjarzadeh

et al. 2019

Nutrition & Dietetics

View full text Add to dashboard Cite

Aim The present study aimed to investigate major dietary patterns and their association with risk of gestational diabetes mellitus (GDM) in Yazd city located in Iran. Methods This case–control designed study was conducted at six healthcare centres. Two hundred and seventy‐eight pregnant women who referred for GDM screening participated. Dietary assessment was carried out by using a 67‐item validated food frequency questionnaire to evaluate dietary history of participants during the last year. Principal component analysis was used to identify major food patterns. Multivariable logistic regression model was employed to identify the association between dietary patterns and risk of GDM. Results Two major dietary patterns were detected. The Western dietary pattern was associated with higher intakes of sugar‐sweetened beverages, refined grain products, fast foods, salty snacks, sweets and biscuit, mayonnaise and saturated oils, while the prudent dietary pattern was associated with higher intakes of fruits, low‐fat dairy, potato, egg, fish, poultry, nuts, organs meat and red meat. Furthermore, prudent dietary pattern was negatively associated with GDM risk (OR = 0.88, 95% CI: 0.44–0.99). However, there was no significant association between adherence of the Western dietary pattern and risk of GDM. Conclusions Pre‐pregnancy adherence of the prudent dietary pattern was significantly associated with reduced risk of GDM.

show abstract

Maternal gestational diabetes and childhood obesity at age 9–11: results of a multinational study

Cited by 100 publications

References 38 publications

Prepubertal Children Exposed to Maternal Gestational Diabetes Have Latent Low-Grade Inflammation

Prepubertal Children Exposed to Maternal Gestational Diabetes Have Latent Low-Grade Inflammation

Effects of maternal obesity on placental function and fetal development

The relationship between pre‐pregnancy dietary patterns adherence and risk of gestational diabetes mellitus in Iran: A case–control study

Contact Info

Product

Resources

About