Maternal Fish Oil Supplementation in Lactation and Growth during the First 2.5 Years of Life

Lauritzen, Lotte; Hoppe, Camilla; Straarup, Ellen Marie; Michaelsen, Kim F.

doi:10.1203/01.pdr.0000169978.92437.58

Cited by 79 publications

(107 citation statements)

References 38 publications

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“…The Danish population has a high intake of n-3 LCPUFA compared to that in many other Western countries [35], which is reflected in relatively high levels of DHA and lower levels of n-6 PUFA in breast-milk and RBC [1,36]. Despite this intervention trial has given evidence of effects on language development, body mass composition (30) and possible visual acuity [29] of an increase in maternal n-3 LCPUFA-intake, indicating that the n-3 PUFA needs of infants may be higher than assumed at the present.…”

Section: Discussionmentioning

confidence: 99%

“…The group size in this randomized trial was based on a power calculation for infant visual acuity, as explained in a previous paper [30]. Around 80% of the infants completed the mental follow-up measures reported in the present paper, resulting in a power to show a difference between the randomized groups of around 0.6 SD of functional outcome.…”

Section: Participants Trial and Supplementsmentioning

confidence: 99%

“…FO-supplementation increased the DHA content of breastmilk and infant erythrocytes (RBC), but this was not found to improve infant visual acuity [29]. Also no difference was found in blood pressure at 2.5 years of age [31], but the body mass index of the children at that age was significantly higher in the FOsupplemented group [30]. The aim of the present paper is to evaluate the effect of maternal FO-supplementation on infant development, problem solving at nine month and early language acquisition.…”

Section: Introductionmentioning

confidence: 99%

“…A reference group of mothers with a habitual fish intake in the upper quartile of the population were also included. The effect on the fatty acid composition of breast-milk and infant erythrocytes (RBC) and visual acuity has been published [29], as have effects on later blood pressure and Maternal n-3 LCPUFA intake and infant development 537 body composition [30,31]. FO-supplementation increased the DHA content of breastmilk and infant erythrocytes (RBC), but this was not found to improve infant visual acuity [29].…”

Section: Introductionmentioning

confidence: 99%

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Maternal fish oil supplementation in lactation: effect on developmental outcome in breast-fed infants

Lauritzen¹,

et al. 2005

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-Docosahexaenoic acid (DHA) accumulates in the brain during the 1st and 2nd years of life. The objective of this study was to see if an increased content of DHA in breast-milk via maternal fish oil (FO)-supplementation affects mental development in term infants. one hundred twenty-two Danish mothers with a habitual fish intake below the population median were randomized to 4.5 g·d -1 of FO or olive oil (OO) for the first four months of lactation. Fifty-three mothers with habitual fish intake in the highest quartile were included as reference group. The effect of the resulting increase in infant DHA-intake and RBC-DHA level was assessed on problem solving ability at nine months and language at one and two years of age. Infants in the three groups performed equally well on the problem test and no association was observed between problem solving and erythrocyte-DHA at four months. Passive vocabulary at one year was lower in the children of the FO-compared with the OOgroup (P < 0.05), but no differences were found at two years of age. Word comprehension at one year was inversely associated with erythrocyte-DHA at four months. The trial indicate a small effect of DHA levels in breast-milk on early language development of breast-fed infants.docosahexaenoic acid / breast-milk / infant development / long-chain n-3 fatty acid / optimal dietary intake Abbreviations: AA: arachidonic acid; CDI: communicative development inventory; DHA: docosahexaenoic acid; FO: fish oil; LCPUFA: long-chain polyunsaturated fatty acid; OO: olive oil; PUFA: polyunsaturated fatty acid; RBC: red blood cells.

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Section: Discussionmentioning

confidence: 99%

Section: Participants Trial and Supplementsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Maternal fish oil supplementation in lactation: effect on developmental outcome in breast-fed infants

Lauritzen¹,

et al. 2005

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“…Adequate DHA intake has been associated with better cognitive development, growth and visual acuity [8][9][10] .…”

Section: Introductionmentioning

confidence: 99%

Supplementation with the omega-3 docosahexaenoic acid: influence on the lipid composition and fatty acid profile of human milk

et al. 2013

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OBJECTIVE: This study assessed the impact of supplementing the diet of women during pregnancy and lactation with fish oil containing the omega-3 fatty acid docosahexaenoic acid, and its influence on the composition of human milk. METHODS: The sample comprised 60 women aged 18 to 38 years with appropriate dietary pattern, all of them healthy and nonsmokers. The intervention consisted of a daily supplementation with fish oil capsules that corresponded to a daily intake of 315mg of docosahexaenoic acid and 80mg of eicosapentaenoic acid during the third trimester of pregnancy and the first three months postpartum. The total fat content and fatty acid profile of their milk were determined by creamatocrit and gas chromatography. Descriptive statistics were used for data analysis and the significance level was set at p<0.05. RESULTS: There was no statistical difference between the fat contents of the study (fish oil capsules) and control (capsules containing corn starch as filler) groups. However, the milk of women taking fish oil contained higher docosahexaenoic and eicosapentaenoic acid levels 30 and 60 days after delivery. These results demonstrate that high omega-3 intake can influence its concentration in human milk. CONCLUSIONS: Given the importance of docosahexaenoic acid in the neonatal period, it is appropriate for pregnant and breastfeeding women to supplement on long-chain polyunsaturated fatty acids, which may be done by adding fish oil to the regular diet.

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Omega-3 fatty acid addition during pregnancy

Middleton

Gomersall

Gould

et al. 2018

Cochrane Database of Systematic Reviews

265

261

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Maternal Fish Oil Supplementation in Lactation and Growth during the First 2.5 Years of Life

Cited by 79 publications

References 38 publications

Maternal fish oil supplementation in lactation: effect on developmental outcome in breast-fed infants

Maternal fish oil supplementation in lactation: effect on developmental outcome in breast-fed infants

Supplementation with the omega-3 docosahexaenoic acid: influence on the lipid composition and fatty acid profile of human milk

Omega-3 fatty acid addition during pregnancy

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