Maternal Factors Pre- and During Delivery Contribute to Gut Microbiota Shaping in Newborns

Rigon, Giuliano; Vallone, Cristina; Lucantoni, V.; Signore, Fabrizio

doi:10.3389/fcimb.2012.00093

Cited by 17 publications

(15 citation statements)

References 31 publications

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“…The developmental diversification of the gut microbes is affected by host factors. These factors include genetics as well as environmental factors such as contact with maternal microbiota during natural delivery or the hospital environment in cesarean‐section delivered infant . In order to account for the maternal transmission of microbiota to the offspring during birth, we analyzed the gut microbiota composition of the dams on low or high vitamin D diets (Supporting Information Fig.…”

Section: Discussionmentioning

confidence: 99%

Low vitamin D status throughout life results in an inflammatory prone status but does not alter bone mineral or strength in healthy 3‐month‐old CD‐1 male mice

Jahani

Fielding

Chen

et al. 2014

Molecular Nutrition Food Res

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Section: Discussionmentioning

confidence: 99%

Low vitamin D status throughout life results in an inflammatory prone status but does not alter bone mineral or strength in healthy 3‐month‐old CD‐1 male mice

Jahani

Fielding

Chen

et al. 2014

Molecular Nutrition Food Res

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“…8,10,11 Infants born via caesarean section have microbial flora similar to environmental microbes, while infants born vaginally have intestinal microbial content similar to the mother’s vaginal and intestinal flora including the commensal bacteria Bacteroides, Bifidobacterium, and Escherichia coli. 12,13 This difference in microbial composition is important because commensal bacteria facilitate the development of the infant’s immune system.…”

mentioning

confidence: 99%

Potential NICU Environmental Influences on the Neonate's Microbiome

Hartz

Bradshaw

Brandon

2015

Advances in Neonatal Care

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“…Microbial gut colonization typically commences at the time of birth, and is influenced by the load (inoculum) of the first maternal microbiota, type of delivery (cesarean section vs vaginal delivery), feeding practices (formula-feeding vs breast-feeding), and antimicrobial use. 15 – 17 The maternal intestinal microbiota clearly determines the type of infant’s intestinal microbiota in the first few months of life. 18 Moreover, it takes a few months for the bacterial species to become steadily consistent, despite the early life complete colonization.…”

Section: Restoration Of Gut Microbiota–intestinal Immunity Relationshmentioning

confidence: 99%

Allergic diseases among children: nutritional prevention and intervention

Hendaus¹,

Jomha²,

Ehlayel³

2016

TCRM

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Allergic diseases comprise a genetically heterogeneous group of chronic, immunomediated diseases. It has been clearly reported that the prevalence of these diseases has been on the rise for the last few decades, but at different rates, in various areas of the world. This paper discusses the epidemiology of allergic diseases among children and their negative impact on affected patients, their families, and societies. These effects include the adverse effects on quality of life and economic costs. Medical interest has shifted from tertiary or secondary prevention to primary prevention of these chronic diseases among high-risk infants in early life. Being simple, practical, and cost-effective are mandatory features for any candidate methods delivering these strategies. Dietary therapy fits this model well, as it is simple, practical, and cost-effective, and involves diverse methods. The highest priority strategy is feeding these infants breast milk. For those who are not breast-fed, there should be a strategy to maintain beneficial gut flora that positively influences intestinal immunity. We review the current use of probiotics, prebiotics, and synbiotics, and safety and adverse effects. Other dietary modalities of possible potential in achieving this primary prevention, such as a Mediterranean diet, use of milk formula with modified (hydrolyzed) proteins, and the role of micronutrients, are also explored. Breast-feeding is effective in reducing the risk of asthma, allergic rhinitis, and atopic eczema among children. In addition, breast milk constitutes a major source of support for gut microbe colonization, due to its bifidobacteria and galactooligosaccharide content. The literature lacks consensus in recommending the addition of probiotics to foods for prevention and treatment of allergic diseases, while prebiotics may prove to be effective in reducing atopy in healthy children. There is insufficient evidence to support soy formulas or amino acid formulas for prevention of allergic disease. A healthy diet, such as the Mediterranean diet, may have a protective effect on the development of asthma and atopy in children. In children with asthma and allergic diseases, vitamin D deficiency correlates strongly with asthma, allergic rhinitis, and wheezing.

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Maternal Factors Pre- and During Delivery Contribute to Gut Microbiota Shaping in Newborns

Cited by 17 publications

References 31 publications

Low vitamin D status throughout life results in an inflammatory prone status but does not alter bone mineral or strength in healthy 3‐month‐old CD‐1 male mice

Low vitamin D status throughout life results in an inflammatory prone status but does not alter bone mineral or strength in healthy 3‐month‐old CD‐1 male mice

Potential NICU Environmental Influences on the Neonate's Microbiome

Allergic diseases among children: nutritional prevention and intervention

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