Maternal factors and associated anomalies in NTD fetuses from Tunisia

Kitova, Тanya; Karaslavova, Emiliya; Masmoudi, Aïda; Gaigi, Soumeya Siala

doi:10.2478/s11536-013-0238-6

Cited by 5 publications

(7 citation statements)

References 17 publications

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“…The total number of participants included was 6086, 384. Ten studies had been conducted in Ethiopia [2, 5, 9-11, 17-20, 64], five in Tunisia [3,8,[21][22][23], eight in Nigeria [6,12,15,16,50,51,65,66], two in Algeria [4,7], six in South Africa [55,59,60,63,67,68], two in Sudan [48,62], and two in Ghana [49,57]. Study was conducted in Kenya [13], Eritrea [14], Libya [52], Egypt [53], Cameron [54], Malawi [58], Tanzania [61], and Democratic Republic (DR) of Congo [47] (Table 1).…”

Section: Resultsmentioning

confidence: 99%

“…The period prevalence, birth outcome, study setting, and study quality were presented in Table 2. In addition to studies explained in Table 2, studies done by Atlaw et al [18], Berihu et al [19], Aynalem et al [20], Nasri et al [21], Bourouba et al [4], Kitova et al [22], and Nasri et al [23] were declared low risk.…”

Section: Resultsmentioning

confidence: 99%

“…Because of its complicated embryologic history, abnormal development of the spinal cord and brain is common [1]. Anencephaly, encephalocele, and spina bifida are the main types of neural tube defects [18][19][20][21][22][23]. The defects are correlated with substantial mortality, morbidity, disability, and psychological and economic costs [24].…”

Section: Introductionmentioning

confidence: 99%

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Birth prevalence of neural tube defects and associated risk factors in Africa: a systematic review and meta-analysis

2021

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Background Neural tube defects are common congenital anomalies that result from early malformation in the development of the spinal cord and brain. It is related to substantial mortality, morbidity, disability, and psychological and economic costs. The aim of this review is to determine the pooled birth prevalence of neural tube defects and associated risk factors in Africa. Methods The first outcome of this review was the pooled birth prevalence of the neural tube defects and the second outcome was the pooled measure of association between neural tube defects and associated risk factors in Africa. We systematically searched PubMed, PubMed Central, Joanna Briggs Institute, Google Scopus, Cochrane Library, African Journals Online, Web of Science, Science Direct, Google Scholar, and Medline databases. The heterogeneity of studies was assessed using the Cochrane Q test statistic, I2 test statistic, and, visually, using Forest and Galbraith’s plots. A random-effect model was applied to get the pooled birth prevalence of neural tube defects. Subgroup, sensitivity, meta-regression, time-trend, and meta-cumulative analyses were undertaken. The fixed-effect model was used to analyze the association between neural tube defects and associated risk factors. Results Forty-three studies with a total of 6086,384 participants were included in this systematic review and meta-analysis. The pooled birth prevalence of the neural tube defects was 21.42 (95% CI (Confidence Interval): 19.29, 23.56) per 10,000 births. A high pooled birth prevalence of neural tube defects was detected in Algeria 75 (95% CI: 64.98, 85.02), Ethiopia 61.43 (95% CI: 46.70, 76.16), Eritrea 39 (95% CI: 32.88, 45.12), and Nigeria 32.77 (95% CI: 21.94, 43.59) per 10,000 births. The prevalence of neural tube defects has increased over time. Taking folic acid during early pregnancy, consanguineous marriage, male sex, and substance abuse during pregnancy were assessed and none of them was significant. Conclusions The pooled birth prevalence of neural tube defects in Africa was found to be high. The risk factors evaluated were not found significant.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Birth prevalence of neural tube defects and associated risk factors in Africa: a systematic review and meta-analysis

2021

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“…In this systematic review and meta-analysis, 60 articles, which included about 3,091,946 births and 52,569 congenital anomalies, were analyzed. Of these, 4 studies were conducted in Ethiopia [30][31][32][33]; 16 studies were conducted in Nigeria [34][35][36][37][38][39][40][41][42][43][44][45][46][47][48]; 9 studies were conducted in Egypt [49][50][51][52][53][54][55][56][57][58][59]; 3 studies were conducted in South Africa [60][61][62][63][64]; 5 studies were conducted in Morocco [65][66][67][68][69]; 6 studies were conducted in Libya [70][71][72][73][74][75]; 2 studies were conducted in Tunisia [76][77]…”

Section: Characteristics Of Included Studiesmentioning

confidence: 99%

Proportion of Chromosomal Disorders and Their Patterns among Births with Congenital Anomalies in Africa: A Systematic Review and Meta-Analyses

Gebremeskel

Gedion

2022

The Scientific World Journal

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Introduction. Worldwide, surveys have shown that the frequency of chromosomal disorders among births with congenital anomalies varies greatly from country to country. It is well known that chromosomal disorders are an important cause of premature death or life-long disability; however, the absence of local epidemiological data on their birth prevalence and outcomes impedes policy and service development in many countries and continents. Therefore, the current systematic review and meta-analysis intend to show the pooled proportion of chromosomal disorders among births with congenital anomalies in Africa. Methods. From PubMed, Cochrane Library, and Google Scholar, we systematically reviewed and meta-analyzed the studies that examined the incidence, prevalence, and types of chromosomal disorders using PRISMA guidelines. A weighted inverse variance random-effects model was used to estimate the pooled proportion of chromosomal disorders among births with congenital anomalies. Results. From the total of 3,569 studies identified, 1,442 were from PubMed, 108 were from Cochrane Library, 1,830 were from Google Scholar, and 189 were from other sources. After duplication was removed, a total of 844 articles remained (2725 were removed by duplication). Finally, 144 full-text studies were reviewed and 60 articles with 52,569 births having congenital anomalies met the inclusion criteria and were selected for this meta-analysis. The pooled proportion of chromosomal disorders among births with congenital anomalies was 8.94% (95% CI; 7.02, 10.86; I2 = 98.8%; p < 0.001 ). Conclusions and Future Implications. In the current systematic review and meta-analysis, the pooled proportion of chromosomal disorders among births with congenital anomalies in Africa was small. Down syndrome (trisomy 21) accounted for more than 80% of chromosomal disorders. The pooled proportion of chromosome disorders was the highest in North African regions and countries compared to other regions of the continent. Healthcare managers should focus on establishing proper cytogenetic diagnostic facilities in collaboration with well-trained genetic counseling services in the continent.

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“…1 Apart from genetic predisposition, some exogenous factors can also contribute to the development of MM such as concomitant maternal diseases, low socioeconomic status, folic acid deficit, etc. 1,2 Despite prophylactic use of folic acid before and during pregnancy, incidence of MM remains high, ranging between 0.1 and 10 per 1,000 live births. 1 This anomaly can affect the entire spinal axis, but the most commonly affected area remains the lumbosacral region followed by the thoracic spine.…”

Section: Introductionmentioning

confidence: 99%

Myelomeningocele with Associated Anomalies – Case Report and Literature Review

Kitov

Kehayov

2019

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Myelomeningocele is a common defect of the development of the neural tube. It is a complex congenital malformation of the central nervous system (CNS) that can be associated with other concurrent anomalies. We report on a case of lumbar myelomeningocele with concomitant CNS malformations we followed up over a period of 15 years. A concise literature review has also been performed. The current report illustrates that the myelomeningocele is a complex anomaly that is commonly associated with a variety of other CNS malformations such as hydrocephalus and Chiari malformation. It may follow chronic progressive course with exacerbation of clinical symptoms in the long term. Patients that have undergone surgical correction of this spinal defect should be closely monitored over a long period of time because of the possibility of clinical deterioration of the concomitant anomalies such as hydrocephalus, Chiari malformation and siryngomyelia.

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Maternal factors and associated anomalies in NTD fetuses from Tunisia

Abstract: Abstract

Cited by 5 publications

References 17 publications

Birth prevalence of neural tube defects and associated risk factors in Africa: a systematic review and meta-analysis

Birth prevalence of neural tube defects and associated risk factors in Africa: a systematic review and meta-analysis

Proportion of Chromosomal Disorders and Their Patterns among Births with Congenital Anomalies in Africa: A Systematic Review and Meta-Analyses

Myelomeningocele with Associated Anomalies – Case Report and Literature Review

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Maternal factors and associated anomalies in NTD fetuses from Tunisia

Abstract: Abstract

Cited by 5 publications

References 17 publications

Birth prevalence of neural tube defects and associated risk factors in Africa: a systematic review and meta-analysis

Birth prevalence of neural tube defects and associated risk factors in Africa: a systematic review and meta-analysis

Proportion of Chromosomal Disorders and Their Patterns among Births with Congenital Anomalies in Africa: A Systematic Review and Meta-Analyses

Myelomeningocele with Associated Anomalies &ndash; Case Report and Literature Review

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Myelomeningocele with Associated Anomalies – Case Report and Literature Review