Maternal exposure to <scp>GOS</scp>/inulin mixture prevents food allergies and promotes tolerance in offspring in mice

Bouchaud, Grégory; Castan, Laure; Chesné, Julie; Braza, Faouzi; Aubert, P.; Neunlist, Michel; Magnan, A.; Bodinier, Marie

doi:10.1111/all.12777

Cited by 51 publications

(34 citation statements)

References 32 publications

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“…Carbohydrates that are indigestible for host enzymes, such as dietary fiber, can be fermented by the gut microbiota, which exerts a prebiotic effect that stimulates the growth of beneficial strains and inhibits colonization by pathogenic bacteria. Supplementation of maternal diet with galacto-oligosaccharides and inulin during pregnancy and breastfeeding has shown an indirect effect on offspring, giving rise to an increased proportion of Lactobacillus species and Clostridium leptum and decreased proportion of Clostridium coccoides and promoting immune tolerance to wheat gliadin in offspring [113]. In addition, bacterial metabolic products including short chain fatty acids (SCFAs) have been shown to directly regulate mucosal immune function and the intestinal barrier [114].…”

Section: Role Of Microbiota and Dietmentioning

confidence: 99%

Immune Basis of Allergic Reactions to Food

Lozano‐Ojalvo

Berin

Tordesillas

2019

J Investig Allergol Clin Immunol

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Food allergies are diseases where the normal tolerance response to oral antigens is altered. Recent advances have begun to uncover mechanisms that mediate sensitization to food allergens and maintenance of the disease. Production of alarmins by epithelial cells triggers a cascade that leads to allergen-specific IgE synthesis. IL-9 has also been shown to play a role in mast cell recruitment and amplification of the allergic response. In recent years, increasing evidence suggests that sensitization to food allergens can be developed via nonoral routes, in particular the skin, thus leading to the "dual exposure hypothesis". Environmental factors such as diet or microbiota can shape the immune system to promote tolerance or sensitization to food antigens. While the mechanism of primary tolerance to food antigens is quite clear, that leading to permanent tolerance in food-allergic individuals through immunotherapy is still under study. Understanding the mechanisms by which oral tolerance is suppressed and sensitization develops will help to identify new targets to develop combined therapies for the treatment of food allergies.

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Section: Role Of Microbiota and Dietmentioning

confidence: 99%

Immune Basis of Allergic Reactions to Food

Lozano‐Ojalvo

Berin

Tordesillas

2019

J Investig Allergol Clin Immunol

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“…In humans, the effects of maternal intake of prebiotics on neurodevelopment have not been well studied, and there is uncertainty about their effects on allergy risk [60, 61]. Galacto-oligosaccharide (GOS) and inulin administration to pregnant mice modulated the gut microbiota and prevented immune activation and intestinal permeability in the offspring [62]. Moreover, it has recently been shown that the addition of inulin to a mouse maternal high-fat diet abrogated the negative metabolic effect of the high-fat diet on offspring [63].…”

Section: External Challenges To Maternal Microbiota Dynamicsmentioning

confidence: 99%

Microbiota and Neurodevelopmental Trajectories: Role of Maternal and Early-Life Nutrition

et al. 2019

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Pregnancy and early life are characterized by marked changes in body microbial composition. Intriguingly, these changes take place simultaneously with neurodevelopmental plasticity, suggesting a complex dialogue between the microbes that inhabit the gastrointestinal tract and the brain. The purpose of this chapter is to describe the natural trajectory of microbiota during pregnancy and early life, as well as review the literature available on its interaction with neurodevelopment. Several lines of evidence show that the gut microbiota interacts with diet, drugs and stress both prenatally and postnatally. Clinical and preclinical studies are illuminating how these disruptions result in different developmental outcomes. Understanding the role of the microbiota in neurodevelopment may lead to novel approaches to the study of the pathophysiology and treatment of neuropsychiatric disorders.

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“…Thus, several studies have provided evidence to support that supplementing with prebiotics and probiotics, specifically during pregnancy, modifies the methylation status of DNA, particularly of obesity promoters and genes related to weight gain in mothers and their infants [91,92]. Some examples of maternal prebiotic during pregnancy associated with programming offspring health, in animal models, are short-chain fructo-oligosaccharides that improve gut defense and immune response [93], galactooligosaccharides and inulin mixture that prevent food allergies [94] and oligofructose that decreases the risk of obesity [95]. Vahamiko, Laiho [96] carried out a pilot study that aimed to find out whether the administration of probiotic supplements during pregnancy might change DNA and the methylation status of obesity promoters and the genes related to weight gain in mothers and their children.…”

Section: Gut Microbiota and Metabolic Programmingmentioning

confidence: 99%

Epigenetics, Maternal Diet and Metabolic Programming

Ramírez‐Alarcón¹,

Sánchez-Agurto²,

Lamperti³

et al. 2019

TOBIOJ

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Background: The maternal environment influences embryonic and fetal life. Nutritional deficits or excesses alter the trajectory of fetus/offspring’s development. The concept of “developmental programming” and “developmental origins of health and disease” consists of the idea that maternal diet may remodel the genome and lead to epigenetic changes. These changes are induced during early life, permanently altering the phenotype in the posterior adult stage, favoring the development of metabolic diseases such as obesity, dyslipidemia, hypertension, hyperinsulinemia, and metabolic syndrome. In this review, it is aimed to overview epigenetics, maternal diet and metabolic programming factors and determine which of these might affect future generations. Scope and Approach: Nutrients interfere with the epigenome by influencing the supply and use of methyl groups through DNA transmethylation and demethylation mechanisms. They also influence the remodeling of chromatin and arginine or lysine residues at the N-terminal tails of histone, thus altering miRNA expression. Fats, proteins, B vitamins and folates act as important cofactors in methylation processes. The metabolism of carbon in the methyl groups of choline, folic acid and methionine to S-Adenosyl Methionine (SAM), acts as methyl donors to methyl DNA, RNA, and proteins. B-complex vitamins are important since they act as coenzymes during this process. Key Findings and Conclusion: Nutrients, during pregnancy, potentially influence susceptibility to diseases in adulthood. Additionally, the deficit or excess of nutrients alter the epigenetic machinery, affecting genes and influencing the genome of the offspring and therefore, predisposing the development of chronic diseases in adults.

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Maternal exposure to GOS/inulin mixture prevents food allergies and promotes tolerance in offspring in mice

Abstract: The treatment of pregnant and lactating mice with nondigestible GOS/inulin prebiotics promotes a long-term protective effect against food allergies in the offspring.

Cited by 51 publications

References 32 publications

Immune Basis of Allergic Reactions to Food

Immune Basis of Allergic Reactions to Food

Microbiota and Neurodevelopmental Trajectories: Role of Maternal and Early-Life Nutrition

Epigenetics, Maternal Diet and Metabolic Programming

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