Maternal exposure to nanoparticulate titanium dioxide during the prenatal period alters gene expression related to brain development in the mouse

Shimizu, Midori; Tainaka, Hitoshi; Oba, Taro; Mizuo, Keisuke; Umezawa, Masakazu; Takeda, Ken

doi:10.1186/1743-8977-6-20

Cited by 227 publications

(163 citation statements)

References 29 publications

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“…In fact, TNPs were shown to be transferred from pregnant mice to their pups [70][71][72][73]. When pregnant mice were treated with TNPs via subcutaneous injection, the genital and cranial nerve systems of the male offspring were affected [70].…”

Section: Developmental Toxicitymentioning

confidence: 99%

The potential health risk of titania nanoparticles

Zhang

Bai

Zhang

et al. 2012

Journal of Hazardous Materials

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Section: Developmental Toxicitymentioning

confidence: 99%

The potential health risk of titania nanoparticles

Zhang

Bai

Zhang

et al. 2012

Journal of Hazardous Materials

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“…Так, ранее было показано, что подкожное введение беременным самкам мышей НЧ TiO2 приводит к определенным повреждениям репродуктивных органов и нейронов центральной нервной системы потомства [22]. По данным этих авторов подкожная инъекция беременным самкам мышей наноформы диоксида титана вызывает изменение экспрессии генов, связанных с развитием мозга, гибелью нейронов, оксидативным стрессом и повышением активности митохондрий в головном мозге в перинатальный период.…”

Section: рисunclassified

The study of embryotoxic effect of titanium dioxide nanoparticles on rats

Sharafutdinova¹,

Хисматуллина²,

Daminov³

et al. 2017

MV-MN

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Для цитирования:Шарафутдинова Л.А., Хисматуллина З.Р., Даминов М.Р., Валиуллин В.В. Исследование эмбриотоксического действия наночастиц диоксида титана на крыс// Морфологические ведомости .-2017.-Том 25.-№ 3.-С. 37-42. https://doi.org/10.20340/mv-mn.17(25) Vedomosti -Morphological Newsletter. 2017 Sep 30;25(3):37-42. https://doi.org/10.20340/mv-mn.17(25).03.37-42 Резюме: Широкое использование наноматериалов в различных отраслях деятельности человека приводит к возникновению ряда проблем. Хорошо известно, что некоторые наноматериалы могут обладать эмбриотоксическим эффектом, оказывая прямое воздействие на плод после проникновения через плацентарный барьер. Цель настоящего исследования -оценить на основе изучения предимплантационной и постимлантационной смертности и особенностей постнатального развития эмбриотоксические свойства нанодисперсного диоксида титана (TiO2) при пероральном введении. Показано, что пероральное введение нанодисперсного диоксида титана в дозе 50 мг/кг беременным самкам крыс с 1-го по 19-й день беременности оказывает выраженное эмбриотоксическое действие, выраженное в повышении предимплантационной, постимплантационной и общей эмбриональной смертности плодов. Изучены отдаленные эффекты антенатального воздействия нанодисперсного диоксида титана на развитие потомства крыс в раннем постанатальном периоде онтогенеза, в первые 30 дней жизни. Установлено повышение смертности крысят в период вскармливания, отставание их в весе и задержка морфофункционального созревания на постнатальном этапе онтогенеза. Таким образом, несмотря на существование биологических барьеров, которые в целом достаточно эффективно защищают развивающийся организм, исследованные нами наночастицы диоксида титана, по-видимому, оказывают существенные эмбриотоксические эффекты, в том числе отсроченные по их проявлению у подвергшегося воздействию потомства.Ключевые слова: наночастицы, диоксид титана, эмбриотоксичность, крыса Summary: The widespread use of nanomaterials in various fields of human activity leads to a number of problems. It is well known that some nanomaterials may have an embryotoxic effect, having a direct effect on the fetus at penetrating through placental barrier. The purpose of this study is to evaluate, on the basis of the study of pre-implantational and post-implantational mortality and features of postnatal development, the embryotoxic properties of nanodispersed titanium dioxide (TiO2) when administered orally. It has been shown that oral administration of 50 mg/kg nanodispersed titanium dioxide to pregnant female rats from the 1st to 19th day of pregnancy has a pronounced embryotoxic effect, expressed in an increase in pre-implantational, post-implantational and total embryonic fetal mortality. The long-term effects of the antenatal effect of nanodispersed titanium dioxide on the development of the offspring of rats in the early postnatal period of ontogenesis were studied in the first 30 days of life. An increase in the death rate of rats during the feeding period, a delay in their weight and a delay in ...

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“…Moreover, they depend on experimental conditions, the route of administration and NP type. However, recent studies imply that NP toxicity might be mediated by oxidative stress and inflammation (Shimizu et al 2009;Wang et al 2010), cell growth inhibition, enhanced apoptotic processes (Hsieh et al 2009;Guo et al 2011), necrosis (KingHeiden et al 2009), and/or DNA damage (Wang et al 2010).…”

Section: Effects Of Nanoparticles On Embryogenesismentioning

confidence: 99%

“…The human placental perfusion model was successfully used in NP transplacental transfer studies and the experimental conditions can be sufficiently maintained to obtain reproducible results, therefore the placental perfusion model could be standardized for the assessment of NP transplacental passage. However placental barrier physiology highly depends on the gestation period (Gude et al 2004;Shimizu et al 2009) what raises the need for other experimental models that would produce data on NP passage in early stages of embryogenesis.…”

Section: Effects Of Nanoparticles On Embryogenesismentioning

confidence: 99%

Transport of Nanoparticles through the Placental Barrier

Kulvietis

Žalgevičienė

Didžiapetrienė

et al. 2011

Tohoku J. Exp. Med.

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Nanoparticles (NP) are organic or inorganic substances, the size of which ranges from 1 to 100 nm, and they possess specific properties which are different from those of the bulk materials in the macroscopic scale. In a recent decade, NP were widely applied in biomedicine as potential probes for imaging, drug-delivery systems and regenerative medicine. However, rapid development of nanotechnologies and their applications in clinical research have raised concerns about the adverse effects of NP on human health and environment. In the present review, special attention is paid to the fetal exposure to NP during the period of pregnancy. The ability to control the beneficial effects of NP and to avoid toxicity during treatment requires comprehensive knowledge about the distribution of NP in maternal body and possible penetration through the maternal-fetal barrier that might impair the embryogenesis. The initial in vivo and ex vivo studies imply that NP are able to cross the placental barrier, but the passage to the fetus depends on the size and the surface coating of NP as well as on the experimental model. The toxicity assays indicate that NP might induce adverse physiological effects and impede embryogenesis. The molecular transport mechanisms which are responsible for the transport of nanomaterials across the placental barrier are still poorly understood, and there is a high need for further studies in order to resolve the NP distribution patterns in the organism and to control the beneficial effects of NP applications during pregnancy without impeding the embryogenesis.

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Maternal exposure to nanoparticulate titanium dioxide during the prenatal period alters gene expression related to brain development in the mouse

Cited by 227 publications

References 29 publications

The potential health risk of titania nanoparticles

The potential health risk of titania nanoparticles

The study of embryotoxic effect of titanium dioxide nanoparticles on rats

Transport of Nanoparticles through the Placental Barrier

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