Maternal exposure to different sizes of polystyrene microplastics during gestation causes metabolic disorders in their offspring

Luo, Ting; Zhang, Yi; Wang, Cai-Yun; Wang, Xiaoyu; Zhou, Jiajie; Shen, Manlu; Zhao, Yao; Fu, Zhengwei; Jin, Yuanxiang

doi:10.1016/j.envpol.2019.113122

Cited by 181 publications

(108 citation statements)

References 58 publications

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“…A comparison of exposure levels in in vivo studies, general exposure to humans from food and discharge via feces, and calculation of consumption from tap and bottled water as the source with the most reliable data, is given in Table 3. Two in vivo studies are excluded from these calculations because data are missing [60,61]. Furthermore, the data from Stock et al, who administered MPs three times a week, have been extrapolated to seven days per week, but it is unclear whether such a dosing scheme is representative of daily exposure [55].…”

Section: Discussionmentioning

confidence: 99%

Section: Rodent Studiesmentioning

confidence: 99%

“…The research group of the Zhejiang University of Technology (China) conducted a set of four studies with mice and examined various effects, including potential effects on the gut microbiome and on F1 and F2 offspring [58][59][60][61]. Exposure levels were comparable and the size ranges matched each other ( [58,60]: 0.5 µm and 50 µm PS; [59,61]: 5 µm PS). The four studies differed among each other with regard to the set of evaluated endpoints, but the main reported effects included (1) an altered composition of the gut microbiota; (2) alterations in the intestinal barrier, demonstrated by decreased secretion of mucus and reduction in gene expression levels of ion transporters in the gut; and (3) modified lipid/fatty acid metabolism, as exemplified by changes in serum and liver triglyceride and total cholesterol levels, as well as gene expression and metabolomic profiling in the serum and liver ( Table 2).…”

Section: Rodent Studiesmentioning

confidence: 99%

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Current Insights into Monitoring, Bioaccumulation, and Potential Health Effects of Microplastics Present in the Food Chain

Raamsdonk

Zande

Koelmans

et al. 2020

Foods

154

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Microplastics (MPs) are considered an emerging issue as environmental pollutants and a potential health threat. This review will focus on recently published data on concentrations in food, possible effects, and monitoring methods. Some data are available on concentrations in seafood (fish, bivalves, and shrimps), water, sugar, salt, and honey, but are lacking for other foods. Bottled water is a considerable source with numbers varying between 2600 and 6300 MPs per liter. Particle size distributions have revealed an abundance of particles smaller than 25 µm, which are considered to have the highest probability to pass the intestinal border and to enter the systemic circulation of mammals. Some studies with mice and zebrafish with short- or medium-term exposure (up to 42 days) have revealed diverse results with respect to both the type and extent of effects. Most notable modifications have been observed in gut microbiota, lipid metabolism, and oxidative stress. The principal elements of MP monitoring in food are sample preparation, detection, and identification. Identified data gaps include a lack of occurrence data in plant- and animal-derived food, a need for more data on possible effects of different types of microplastics, a lack of in silico models, a lack of harmonized monitoring methods, and a further development of quality assurance.

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Section: Discussionmentioning

confidence: 99%

Section: Rodent Studiesmentioning

confidence: 99%

Section: Rodent Studiesmentioning

confidence: 99%

See 1 more Smart Citation

Current Insights into Monitoring, Bioaccumulation, and Potential Health Effects of Microplastics Present in the Food Chain

Raamsdonk

Zande

Koelmans

et al. 2020

Foods

154

View full text Add to dashboard Cite

show abstract

“…Pathological changes to the gut include a reduction in mucus secretion [90], gut barrier dysfunction [104,106], intestinal inflammation [107] and gut microbiota dysbiosis [90,104,106,107]. Liver pathologies documented include inflammation and lipid accumulation or lipid profile changes [90,102,106], as well as changes in the markers of lipid metabolism [90,105,108]. Other metabolic problems noted by omics-type analyses include disorders in energy metabolism [102,105] and bile acid metabolism [104].…”

Section: Toxicity Of Mps/nps In Mouse Modelsmentioning

confidence: 99%

“…Recently, Luo and colleagues documented that maternal exposure to PS during gestation causes metabolic disorders in the offspring [106,108]. As in fishes, MPs aggravated the toxicity of an environmental toxicant, organophosphorus flame retardants (OPFRs) [103].…”

Section: Toxicity Of Mps/nps In Mouse Modelsmentioning

confidence: 99%

Toxicity of Microplastics and Nanoplastics in Mammalian Systems

Yong

Valiyaveettil

Tang

2020

IJERPH

520

280

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Fragmented or otherwise miniaturized plastic materials in the form of micro- or nanoplastics have been of nagging environmental concern. Perturbation of organismal physiology and behavior by micro- and nanoplastics have been widely documented for marine invertebrates. Some of these effects are also manifested by larger marine vertebrates such as fishes. More recently, possible effects of micro- and nanoplastics on mammalian gut microbiota as well as host cellular and metabolic toxicity have been reported in mouse models. Human exposure to micro- and nanoplastics occurs largely through ingestion, as these are found in food or derived from food packaging, but also in a less well-defined manner though inhalation. The pathophysiological consequences of acute and chronic micro- and nanoplastics exposure in the mammalian system, particularly humans, are yet unclear. In this review, we focus on the recent findings related to the potential toxicity and detrimental effects of micro- and nanoplastics as demonstrated in mouse models as well as human cell lines. The prevailing data suggest that micro- and nanoplastics accumulation in mammalian and human tissues would likely have negative, yet unclear long-term consequences. There is a need for cellular and systemic toxicity due to micro- and nanoplastics to be better illuminated, and the underlying mechanisms defined by further work.

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Plastics in the Anthropocene

Andrady

2022

Plastics and the Ocean

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Maternal exposure to different sizes of polystyrene microplastics during gestation causes metabolic disorders in their offspring

Cited by 181 publications

References 58 publications

Current Insights into Monitoring, Bioaccumulation, and Potential Health Effects of Microplastics Present in the Food Chain

Current Insights into Monitoring, Bioaccumulation, and Potential Health Effects of Microplastics Present in the Food Chain

Toxicity of Microplastics and Nanoplastics in Mammalian Systems

Plastics in the Anthropocene

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