Maternal exposure to Cochlospermum regium: a toxicological evaluation

Cunha-Laura, Andréa Luiza; Oliveira, Rodrigo Juliano; Barros, Andrea Lantieri Correa de; Siqueira, João Máximo de; Vieira, Maria do Carmo; Auharek, Sarah Alves

doi:10.1590/s0102-695x2013005000005

Cited by 8 publications

(7 citation statements)

References 16 publications

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“…In this study, no alteration in embryo viability markers was observed, including implants ratio, pre-and post-implantation loss per group ratio, or birth rate. In addition, the dose tested in the present study showed no direct teratogenic effects since the live fetuses showed normal development (Cunha-Laura et al, 2013) with no visceral or skeletal malformations. The size of the fetus, including body weight and placenta, were similar in all experimental groups, indicating that the treatments did not affect the availability of nutrients needed for maintaining maternal metabolism and fetal development.…”

Section: Discussionmentioning

confidence: 51%

Effects of Maytenus ilicifolia on reproduction and embryo-fetal development in Wistar rats

Cunha-Laura¹,

Auharek²,

Oliveira³

et al. 2014

Genet. Mol. Res.

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ABSTRACT. Maytenus ilicifolia (Celastraceae), popularly known as espinheira-santa, is a native plant from the Atlantic forest and is commonly used in popular medicine to treat inflammation and as an abortifacient. To evaluate the effects of M. ilicifolia on pregnant rats during the organogenic period (T1) or throughout the gestational period (T2), an extract obtained using an acetone-water mixture at a 70:30 ratio was administered via gavage at a dose of 15.11 mg·kg hydroacetonic extract is non-toxic to pregnant rats and appears to not interfere with the progress of embryo-fetal development.

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Section: Discussionmentioning

confidence: 51%

Effects of Maytenus ilicifolia on reproduction and embryo-fetal development in Wistar rats

Cunha-Laura¹,

Auharek²,

Oliveira³

et al. 2014

Genet. Mol. Res.

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“…The C. regium EEF did not show cytotoxicity against VERO cells and it evidenced a potential antiproliferative activity against HeLa cells. Another study has also shown absence of cytotoxicity in C. regium [ 48 ].…”

Section: Discussionmentioning

confidence: 99%

In Vitro Control of Uropathogenic Microorganisms with the Ethanolic Extract from the Leaves of Cochlospermum regium (Schrank) Pilger

Leme

Rodrigues

Almeida-Apolonio

et al. 2017

Evidence-Based Complementary and Alternative Medicine

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The roots of Cochlospermum regium, popularly known as “algodãozinho-do-cerrado,” are used for the treatment of genitourinary infections. However, the removal of their subterranean structures results in the death of the plant, and the use of the leaves becomes a viable alternative. Therefore, the antimicrobial activity of Cochlospermum regium leaf's ethanolic extract and its action on the biofilm formation of microorganisms associated with urinary infection were evaluated. The total phenolic compounds, flavoids, and tannins were quantified using the reagents Folin-Ciocalteu, aluminum chloride, and vanillin, respectively. The antimicrobial activity was evaluated by the broth microdilution method and the effect of the extract in the biofilm treatment was measured by the drop plate method. Cytotoxicity was evaluated by the method based on the reduction of MTS and the mutagenicity by the Ames test. The ethanolic extract of C. regium leaves presented 87.4 mg/EQ of flavonoids, 167.2 mg/EAG of total phenolic compounds, and 21.7 mg/ECA of condensed tannins. It presented reduction of the biofilm formation for E. coli and C. tropicalis and antimicrobial action of 1 mg/mL and 0.5 mg/mL, respectively. The extract showed no cytotoxicity and mutagenicity at the concentrations tested. This study demonstrated that C. regium leaves are a viable option for the treatment of genitourinary infections and for the species preservation.

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“…For this purpose, the diameters of forty nuclei were measured for each animal. Hepatocyte nuclear volume was expressed in μ m 3 and obtained using the formula 4/3 πr 3, where r = nuclear diameter/2 [ 28 ]. In the kidney, the same analyses were performed, and the nuclear volume of the cells of the proximal convoluted tubule was estimated.…”

Section: Methodsmentioning

confidence: 99%

Adulteration and Contamination of Commercial Sap of Hymenaea Species

Farias

Auharek²,

Cunha-Laura³

et al. 2017

Evidence-Based Complementary and Alternative Medicine

Self Cite

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The Hymenaea stigonocarpa and Hymenaea martiana species, commonly known as “jatobá,” produce a sap which is extracted by perforation of the trunk and is commonly used in folk medicine as a tonic. For this study, the authenticity of commercial samples of jatobá was verified by the identification of the main compounds and multivariate analysis and contamination by microbial presence analysis. The acute toxicity of the authentic jatobá sap was also evaluated. The metabolites composition and multivariate analysis revealed that none of the commercial samples were authentic. In the microbiological contamination analysis, five of the six commercial samples showed positive cultures within the range of 1,700–100,000 CFU/mL and the authentic sap produced no signs of toxicity, and from a histological point of view, there was the maintenance of tissue integrity. In brief, the commercial samples were deemed inappropriate for consumption and represent a danger to the population.

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Maternal exposure to Cochlospermum regium: a toxicological evaluation

Cited by 8 publications

References 16 publications

Effects of Maytenus ilicifolia on reproduction and embryo-fetal development in Wistar rats

Effects of Maytenus ilicifolia on reproduction and embryo-fetal development in Wistar rats

In Vitro Control of Uropathogenic Microorganisms with the Ethanolic Extract from the Leaves of Cochlospermum regium (Schrank) Pilger

Adulteration and Contamination of Commercial Sap of Hymenaea Species

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