Effects of Maytenus ilicifolia on reproduction and embryo-fetal development in Wistar rats

Cunha-Laura, Andréa Luiza; Auharek, Sarah Alves; Oliveira, Rodrigo Juliano; Siqueira, João Máximo de; Vieira, M.C.; Leite, Vessia Silva; Portugal, L C

doi:10.4238/2014.may.9.16

Cited by 7 publications

(2 citation statements)

References 26 publications

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“…There were no fetus anomalies or malformation, with no effects on reabsorption, number of implantations, and dead and live fetuses. The study indicated that M. ilicifolia does not interfere with development of the embryonic fetus and is nontoxic throughout gestation or during the organogenic period (Cunha‐Laura et al, 2014).…”

Section: Methodsmentioning

confidence: 99%

Is it safe to consume traditional medicinal plants during pregnancy?

Bernstein

Akram

Yaniv-Bachrach

et al. 2020

Phytotherapy Research

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The popularity of natural medicine is growing worldwide. Unlike conventional licensed medicines, herbal medicine practices are usually not supported by effectiveness, efficacy, or safety studies, which raise concerns about potential risks involved in their usage, particularly in high‐risk patients such as pregnant women where teratogenicity is a concern. Despite a lack of science‐based evidence, the use of herbal products for the management of pregnancy‐associated challenges is common, due to the common notion that they are free of toxic effects and adverse reactions because they are “natural.” The lack of concern about utilizing herbal remedies during pregnancy is strengthened by the lack of regulation in most countries for their marketing. However, plant‐based remedies are not free of adverse reactions. Medicinal plants and herbal remedies contain substances that can be toxic to the human body and the fetus. Potential effects of indiscriminate use of medicinal plants are embryotoxicity, teratogenic, and abortifacient effects. Some plant constituents can cross the placenta and reach the fetus. Phytochemicals and their metabolites are known to induce stimulation of uterine contraction and hormone imbalance that could result in abortion. The alterations to the hormonal profile can affect conception, induce teratogenic activity, and halt the pregnancy or produce a congenital malformation. Due to the wide range of modes of action of phytochemicals, some medicinal plants may be safe to use during certain trimesters of pregnancy and harmful at other stages. This manuscript reviews available scientific information concerning potential health hazards associated with the consumption of herbal medicines during pregnancy, highlighting those herbs that should be avoided due to their potential abortifacient and/or teratogenic activity. We focused on plants that were tested by preclinical studies, and studies of these plants are summarized. Common therapeutic use of these herbs, estimated effects, toxicological effects, and animal studies of these plants is summarized. The literature reviewed suggests that consumption of the following medicinal plants should be avoided during pregnancy: Abrus precatorius, Achyranthes aspera, Ailanthus excelsa, Aloe vera, Aristolochia indica, Areca catechu, Bambusa vulgaris, Cassia occidentalis, Cicer arietinum, Cimicifuga racemose, Dolichandrone falcate, Ginkgo biloba, Hydrastis canadensis, Indigofera trifoliate, Lavandula latifolia, Maytenus ilicifolia, Momordica cymbalaria, Moringa oleifera, Musa rosacea, Oxalis corniculate, Phytolacca dodecandra, Plumeria rubra, Ricinus communis, Ruta graveolens, Stachys lavandulifolia, Senna alata, Trigonella foenum‐graecum, Vitus agnus‐castus, and Valeriana officinalis.

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Section: Methodsmentioning

confidence: 99%

Is it safe to consume traditional medicinal plants during pregnancy?

Bernstein

Akram

Yaniv-Bachrach

et al. 2020

Phytotherapy Research

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“…S tudies have evaluated and reinforced the safety in the use of this plant in different experimental models. 16 , 17 , 18 , 19 , 20 Tannins have healing properties, as they promote the precipitation of proteins leading to the appearance of a protective layer that can improve the regenerative process. 21 Despite this, to date, studies on the pharmaceutical potential of the bioactive compounds of M. ilicifolia have only addressed the forms used in the healing of gastric ulcers.…”

Section: Introductionmentioning

confidence: 99%

Wound healing activity of the hydroethanolic extract of the leaves of Maytenus ilicifolia Mart. Ex Reis

Moura

Ferreira

Deconte

et al. 2021

Journal of Traditional and Complementary Medicine

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Background and Aim Maytenus ilicifolia has analgesic, healing, antioxidant and anti-inflammatory properties. This study evaluated effect of the hydroalcoholic extract of M. ilicifolia leaves on skin wound repair. Experimental procedure Wounds were induced on mice and treated with the extract. The treatment was performed daily, until day 7 after wound induction. Wound closure was measured and the features of the repaired tissue were investigated, including mast cell quantification, neutrophil and macrophage activities, collagen deposition, angiogenesis, and pro-metalloproteases and metalloproteases 2 and 9 activity (pro-MMPs and MMPs). Results and conclusion The M. ilicifolia extract accelerated the closure of wounds. The extract at a concentration of 4% was found to be effective, presenting anti-inflammatory effects and hemoglobin increased, along with increased soluble, total and type III collagens in the wound. In addition, there was an increase in pro-MMP9 and MMP9 activity after day 7th of treatment. The phenolic compounds and tannins present in this plant could be associated with the anti-inflammatory and healing activities observed in this study. Therefore, the ability to modulate essential parameters for accelerated and adequate healing as shown here suggests that the use of standardised extracts of M. ilicifolia and its fractions enriched in polyphenols may represent a therapeutic strategy for the treatment of wounds.

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Mesopotamia-Paranaense Forest

Álvarez

2019

Pharmacological Properties of Native Plants From Argentina

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Effects of Maytenus ilicifolia on reproduction and embryo-fetal development in Wistar rats

Cited by 7 publications

References 26 publications

Is it safe to consume traditional medicinal plants during pregnancy?

Is it safe to consume traditional medicinal plants during pregnancy?

Wound healing activity of the hydroethanolic extract of the leaves of Maytenus ilicifolia Mart. Ex Reis

Mesopotamia-Paranaense Forest

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