Maternal DNA Methylation During Pregnancy: a Review

Das, Jagyashila; Maitra, Arindam

doi:10.1007/s43032-020-00456-4

Cited by 19 publications

(14 citation statements)

References 139 publications

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“…Besides, DNA hypomethylation of synaptophysin (SYP) promoter increased the expression level of SYP, promoting cortisol secretion and proliferation of CPA [ 21 ]. Several studies had demonstrated that some of the pregnancy-related factors can influence maternal DNA methylation, which was closely associated with gestational diabetes and anemia, adverse pregnancy outcomes like preterm birth, and preeclampsia [ 22 , 23 ]. Therefore, we hypothesized that DNA methylation may be involved in pregnant patients with CPA through regulating the expression of genes associated with the progression of adrenocortical adenoma.…”

Section: Discussionmentioning

confidence: 99%

Alterations of DNA methylation were associated with the rapid growth of cortisol-producing adrenocortical adenoma during pregnancy

et al. 2021

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Background Cortisol-producing adrenocortical adenoma (CPA) during pregnancy rarely occurs in clinic. Growing evidence suggests that DNA methylation plays a key role in adrenocortical adenomas. The present study aims to examine the genome-wide DNA methylation profiles and identify the differences in DNA methylation signatures of non-pregnant and pregnant patients with CPA. Results Four pregnant and twelve non-pregnant patients with CPA were enrolled. The pregnant patients with CPA had higher serum cortisol, Estradiol, Progesterone, and human chorionic gonadotropin concentration, while having lower serum FSH (follicle-stimulating hormone) and luteinizing hormone concentrations (P < 0.01). Compared with the non-pregnant patients, the duration is shorter, and the growth rate of the tumor is faster in pregnant patients with CPA (P < 0.05). Morphology and cell proliferation assay showed that the percentage of Ki-67 positive cells in CPA were higher in pregnant group than non-pregnant group (8.0% vs 5.5%, P < 0.05). The DNA methylation analysis showed that Genome-wide DNA methylation signature difference between pregnant and non-pregnant with CPA, that the pregnant group had more hypermethylated DMPs (67.94% vs 22.16%) and less hypomethylated DMPs (32.93% vs 77.84%). The proportion of hypermethylated DMPs was relatively high on chromosomes 1 (9.68% vs 8.67%) and X (4.99% vs 3.35%) but lower on chromosome 2(7.98% vs 12.92%). In pregnant patients with CPA, 576 hypomethylated DMPs and 1109 hypermethylated DMPs were identified in the DNA promoter region. Bioinformatics analysis indicated that the Wnt/β-Catenin pathway, Ras/MAPK Pathway and PI3K-AKT Pathway were associated with the development of CPA during pregnancy. Conclusions Genome-wide DNA methylation profiling of CPA in non-pregnant and pregnant patients was identified in the present study. Alterations of DNA methylation were associated with the pathogenesis and exacerbation of CPA during pregnancy.

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Section: Discussionmentioning

confidence: 99%

Alterations of DNA methylation were associated with the rapid growth of cortisol-producing adrenocortical adenoma during pregnancy

et al. 2021

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“…Women of any parity were included in the current study if they completed the questionnaires and had blood drawn between 8-18 weeks gestation. This gestational period was selected in order to examine a homogenous sample of DNAm which is likely to fluctuate over the course of pregnancy (Das and Maitra, 2021) and to detect differences in DNAm as early predictors of PTB. Women with PTB were matched with women with term birth on maternal age, smoking status, and history of prior PTB.…”

Section: Methodsmentioning

confidence: 99%

DNA Methylation Patterns of Glucocorticoid Pathway Genes in Preterm Birth Among Black Women

Nowak

Anderson

Ford

et al. 2022

Biological Research For Nursing

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Preterm birth (PTB; <37 weeks gestation) rates have increased for 5 of the last 6 consecutive years in the United States. These rates are particularly alarming for U.S. non-Hispanic Black women who give birth prematurely at 1.5 times the rate of non-Hispanic White women. Previous research suggests that psychological stress is associated with PTB in Black women. However, the biological pathways by which stress alters birth timing are not clear. We examined DNA methylation (DNAm) in peripheral blood leukocytes in 6 glucocorticoid, stress-related genes in 44 (22 PTB; 22 term birth) pregnant Black women. Four cytosine-phosphate-guanine (CpG) sites were identified as differentially methylated ( p < 0.05) between women with PTB and women with term births. The ability to identify stress-related biological markers that are associated with PTB among Black women would provide a critical step toward decreasing the PTB disparity among these women. Future studies should include larger sample sizes and gene expression analyses of the stress-related biological pathways to PTB.

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“…Recent advances have shown that these differences are partly a result of genetic predispositions, and multiple single nucleotide polymorphisms were linked to an increased risk for IAI and spontaneous preterm birth (262,263,(266)(267)(268)(269). Nevertheless, environmental factors, such as psychosocial and socioeconomic factors, maternal stress, and epigenetic changes, contribute to the disparities between demographic groups (270)(271)(272)(273)(274). For example, psychological stress and depression likely promote preterm birth through inflammation, as is evidenced by increased proinflammatory cytokines IL-6 and TNF-a in the maternal serum (275,276).…”

Section: Environmental and Endogenous Factors Influence The Immune Response In Iaimentioning

confidence: 99%

The Role of Innate Immune System in the Human Amniotic Membrane and Human Amniotic Fluid in Protection Against Intra-Amniotic Infections and Inflammation

2021

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Intra-amniotic infection and inflammation (IAI) affect fetal development and are highly associated with preterm labor and premature rupture of membranes, which often lead to adverse neonatal outcomes. Human amniotic membrane (hAM), the inner part of the amnio-chorionic membrane, protects the embryo/fetus from environmental dangers, including microbial infection. However, weakened amnio-chorionic membrane may be breached or pathogens may enter through a different route, leading to IAI. The hAM and human amniotic fluid (hAF) respond by activation of all components of the innate immune system. This includes changes in 1) hAM structure, 2) presence of immune cells, 3) pattern recognition receptors, 4) cytokines, 5) antimicrobial peptides, 6) lipid derivatives, and 7) complement system. Herein we provide a comprehensive and integrative review of the current understanding of the innate immune response in the hAM and hAF, which will aid in design of novel studies that may lead to breakthroughs in how we perceive the IAI.

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Maternal DNA Methylation During Pregnancy: a Review

Cited by 19 publications

References 139 publications

Alterations of DNA methylation were associated with the rapid growth of cortisol-producing adrenocortical adenoma during pregnancy

Alterations of DNA methylation were associated with the rapid growth of cortisol-producing adrenocortical adenoma during pregnancy

DNA Methylation Patterns of Glucocorticoid Pathway Genes in Preterm Birth Among Black Women

The Role of Innate Immune System in the Human Amniotic Membrane and Human Amniotic Fluid in Protection Against Intra-Amniotic Infections and Inflammation

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