Alterations of DNA methylation were associated with the rapid growth of cortisol-producing adrenocortical adenoma during pregnancy

Sun, Yujing; Yin, Xiaofei; Feng, Ruoqi; Feng, Ruiying; Xu, Mingyue; Liang, Kai; Zhao, Ruxing; Gu, Gang-Li; Jiang, Xuewen; Su, Peng; Zhang, Xiaofang; Wang, Zhibin

doi:10.1186/s13148-021-01205-3

Cited by 5 publications

(1 citation statement)

References 43 publications

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“…On the other hand, mutations in this gene give rise to unilateral cortisol‐producing adrenal adenomas [ 17 ]. At the same time, it is possible that altered DNA methylation and insulin‐like growth factor 2 (IGF2) overexpression are involved in the progression of adrenocortical tumours and the promotion of cell proliferation [ 18 , 19 ].…”

Section: Discussionmentioning

confidence: 99%

Cushing's Syndrome in Pregnancy Secondary to Adrenocortical Adenoma: A Case Series and Review

Wang,

An,

Hou

et al. 2024

Endocrino Diabet & Metabol

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PurposeTo present a case series of Cushing's syndrome (CS) during pregnancy caused by adrenocortical adenomas, highlighting clinical features, hormonal assessments and outcomes.MethodsWe describe five pregnant women with CS, detailing clinical presentations and laboratory findings.ResultsCommon clinical features included a full moon face, buffalo back and severe hypertension. Elevated blood cortisol levels with circadian rhythm disruption and suppressed adrenocorticotrophic hormone (ACTH) levels were observed. Imaging revealed unilateral adrenal tumours. Two cases underwent laparoscopic adrenalectomies during the second trimester, while three had postpartum surgery. All required hormone replacement therapy, with postoperative pathological confirmation of adrenocortical adenomas.ConclusionDiagnosis of CS during pregnancy is challenging due to overlapping features with normal pregnancy: elevated blood cortisol levels and abnormal diurnal rhythm of blood cortisol, suppressed aid diagnosis. Treatment should be individualised due to a lack of explicit optimum therapeutic approaches. Laparoscopic adrenalectomy may be an optimal choice, along with multidisciplinary management including hormone replacement therapy.

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Section: Discussionmentioning

confidence: 99%

Cushing's Syndrome in Pregnancy Secondary to Adrenocortical Adenoma: A Case Series and Review

Wang,

An,

Hou

et al. 2024

Endocrino Diabet & Metabol

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Pregnancies complicated with functioning adrenal adenomas causing severe obstetric outcomes: a 20-year experience at a tertiary center

Zhu,

Cai,

Zhong

et al. 2024

BMC Endocr Disord

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Background Functioning adrenal adenoma during pregnancy is rare, and the diagnosis is challenging owing to unspecific symptoms and restricted investigations. The obstetric outcomes of patients who undergo surgery during pregnancy or who receive only medical treatment are poorly described. Objective The aim was to investigate the associations between functioning adrenal adenomas and obstetric outcomes. Methods A retrospective study was performed in a tertiary center over 20 years. The clinical characteristics, management and obstetric outcomes of the diagnosed pregnant women were reviewed. Results A total of 12 women were diagnosed with functioning adrenal adenomas during pregnancy from January 2002 to September 2022. Eight women had cortisol-secreting adrenal adenomas, two had excessive catecholamine secretion, and two had primary aldosteronism. The initial symptoms of adrenal adenoma during pregnancy included hypertension or preeclampsia, gestational diabetes mellitus or prepregnancy diabetes mellitus, hypokalemia and ecchymosis. Four women underwent adrenalectomy during pregnancy, while 8 women received only medical therapy. Preterm birth occurred in all patients who received medicine, whereas 1 patient who underwent surgery experienced preterm birth. Among the 8 women in the medical treatment group, 3 had neonates who died. Conclusions Once hypertension, hyperglycemia and hypokalemia occur during the 1st or 2nd trimester, pregnant women with adrenal adenomas should be evaluated via laboratory and imaging examinations. The maternal and fetal outcomes were unpredictable owing to the severity of adrenal adenoma, particularly in patients who received only medical treatment. Adrenalectomy should be recommended during pregnancy.

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Pregnancy complicated with adrenal adenoma causing severe obstetric outcomes: A 20-year experience at a tertiary center

Zhu

Cai

Zhang

et al. 2023

Preprint

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Background Adrenal adenoma during pregnancy is rare and the diagnosis is challenging owing to unspecific symdromes and restricted investigation. It’s poorly described obstetric outcomes of patients underwent surgery during pregnancy or only received medicine treatment. Objective To investigate the association between adrenal adenoma and obstetric outcomes. Methods A retrospective study was performed. The clinical characteristics, management and obstetric outcome of pregnancies diagnosed as adrenal adenoma over 20 years were reviewed from a teriary hospital. Results A total of 12 women were diagnosed as adrenal adenoma during pregnancy from to January 2000 to September 2022. Eight women had cortisol-secreting adrenal adenoma, two had over-secrete catecholamine and two primary aldosteronism. The original symptoms adrenal adenoma during pregnancy included hypertension or preeclampsia, gestational diabetes mellitus or pre-pregnancy diabetes mellitus, hypokalemia and ecchymosis. There were four women took adrenalectomy during pregnancy, while 8 women only received medicine therapy. Preterm birth occurred in all cases who received medicine, whereas 1 case suffered from preterm birth in the group underwent surgery. Among the 8 women of medicine group, there were 3 neonatal death. Conclusions Once simultaneous onset of hypertension, hyperglycemia and hypokalemia during the 1st or 2nd trimester, adrenal adenoma should be investigate by laboratory examination and imaging examination. The maternal and fetal outcome were unpredictive owing to the severity of adrenal adenoma, particular in patients only received medicine treatment. Adrenalectomy should be recommended during the pregnancy.

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Alterations of DNA methylation were associated with the rapid growth of cortisol-producing adrenocortical adenoma during pregnancy

Cited by 5 publications

References 43 publications

Cushing's Syndrome in Pregnancy Secondary to Adrenocortical Adenoma: A Case Series and Review

Cushing's Syndrome in Pregnancy Secondary to Adrenocortical Adenoma: A Case Series and Review

Pregnancies complicated with functioning adrenal adenomas causing severe obstetric outcomes: a 20-year experience at a tertiary center

Pregnancy complicated with adrenal adenoma causing severe obstetric outcomes: A 20-year experience at a tertiary center

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