Maternal disease and gasotransmitters

Rengarajan, Aishwarya; Mauro, Amanda K.; Boeldt, Derek S.

doi:10.1016/j.niox.2020.01.001

Cited by 13 publications

(10 citation statements)

References 154 publications

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“…This supports our hypothesis that FLA and FLV are potential biomarkers for pregnancy complications, because gasotransmitters such as nitric oxide, carbon monoxide and hydrogen sulphide have been implicated in preeclampsia and preterm birth and it seems that nitric oxide production, nitric oxide synthase activation as well as expression is downregulated in preeclampsia (Rengarajan et al. 2020). In patients with type 1 diabetes, flicker‐induced vasodilatation was reduced while the vascular response to exogenous nitric oxide was not altered.…”

Section: Discussionsupporting

confidence: 89%

Retinal vessel diameters, flicker‐induced retinal vasodilation and retinal oxygen saturation in high‐ and low‐risk pregnancy

Sharifizad

Schmidl

Werkmeister

et al. 2020

Acta Ophthalmologica

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Purpose To compare retinal vascular parameters between high‐risk and low‐risk pregnant women over time during pregnancy. Methods In a longitudinal study, we included pregnant women with normal blood pressure and normal body mass index (BMI, group 1), pregnant women with systemic hypertension and/or overweight (group 2) and age‐matched nonpregnant healthy women (group 3). Using the dynamic vessel analyser (DVA) we investigated flicker‐induced vasodilation in retinal arteries (FLA) and veins (FLV), central retinal arterial and vein equivalent (CRAE, CRVE), arterio‐venous ratio (AVR) and retinal arterial and venous oxygen saturation (SartO2, SveinO2). Study visits were scheduled 2nd trimester (TP 2), 3rd trimester (TP 3) and postpartum (PP). Results Data from 29 women in group 1, 25 women in group 2 and 33 women in group 3 were included for analysis. FLA, FLV, CRAE, CRVE, AVR and SveinO2 were altered in group 2 (p‐values between < 0.001 and 0.009). At TP 3 the differences between groups were most pronounced. In contrast, there were only minor differences between group 1 and 3. Changes in retinal parameters were independently associated with systemic blood pressure and BMI. Conclusions The present analysis indicates that flicker‐induced retinal vasodilation, retinal vessel diameters and retinal oxygen saturation are altered in high‐risk pregnant women. Hence, these parameters are candidate biomarkers for pregnancy complications, a hypothesis that deserves further study.

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Section: Discussionsupporting

confidence: 89%

Retinal vessel diameters, flicker‐induced retinal vasodilation and retinal oxygen saturation in high‐ and low‐risk pregnancy

Sharifizad

Schmidl

Werkmeister

et al. 2020

Acta Ophthalmologica

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“…[10,12,13,[20][21][22]. Gasotransmitters play a crucial role in the regulation of maternal hemodynamics, placenta vascular development, embryogenesis, feto-placental vascular reactivity, and fetal development during pregnancy [23][24][25]. Abnormalities of gasotransmitter production and signaling in compromised pregnancy are linked to adverse pregnancy and fetal outcomes.…”

Section: Implications Of Gasotransmitters In Pregnancymentioning

confidence: 99%

“…Collectively, NO, CO, and H 2 S play crucial roles for normal pregnancy. Dysregulated gasotransmitter signaling has been linked to preeclampsia, IUGR, stillbirth, and preterm labor [24,25]. Although specific mechanisms mediating cellular and organismal changes in pregnancy due to gasotransmitters await further exploration, emerging evidences suggest their therapeutic potential for compromised pregnancy to improve maternal and fetal outcomes.…”

Section: Hydrogen Sulfidementioning

confidence: 99%

Gasotransmitters for the Therapeutic Prevention of Hypertension and Kidney Disease

Hsu

Tain

2021

IJMS

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Nitric oxide (NO), carbon monoxide (CO), and hydrogen sulfide (H2S), three major gasotransmitters, are involved in pleiotropic biofunctions. Research on their roles in hypertension and kidney disease has greatly expanded recently. The developing kidney can be programmed by various adverse in utero conditions by so-called renal programming, giving rise to hypertension and kidney disease in adulthood. Accordingly, early gasotransmitter-based interventions may have therapeutic potential to revoke programming processes, subsequently preventing hypertension and kidney disease of developmental origins. In this review, we describe the current knowledge of NO, CO, and H2S implicated in pregnancy, including in physiological and pathophysiological processes, highlighting their key roles in hypertension and kidney disease. We summarize current evidence of gasotransmitter-based interventions for prevention of hypertension and kidney disease in animal models. Continued study is required to assess the interplay among the gasotransmitters NO, CO, and H2S and renal programming, as well as a greater focus on further clinical translation.

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“…Over the last decades, the knowledge on the significance of the gaseous molecule H 2 S in endothelial function and dysfunction has grown exponentially 16,17 . However, the molecular mechanisms underlying H 2 S‐mediated cardiovascular homeostasis, particularly in HDP are still unclear.…”

Section: Discussionmentioning

confidence: 99%

Circulating levels of hydrogen sulphide negatively correlate to nitrite levels in gestational hypertensive and preeclamptic pregnant women

Possomato-Vieira

Palei

Pinto-Souza

et al. 2021

Clin Exp Pharma Physio

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Endothelial dysfunction is a hallmark of preeclampsia and the role of nitric oxide (NO) has been extensively studied in this pregnancy complication. In recent years, hydrogen sulphide (H2S) has arisen as a new gasotransmitter with an impact on endothelial function. However, the involvement of H2S in the pathophysiology of preeclampsia is not fully understood, and only a few studies with limited sample size have investigated circulating levels of H2S in preeclamptic patients. Moreover, H2S levels have not been previously evaluated in gestational hypertension. Furthermore, the relationship between H2S and NO in these hypertensive disorders of pregnancy has yet to be determined. We measured H2S levels in plasma of 120 healthy pregnant women, 88 gestational hypertensive and 62 preeclamptic women. We also measured plasma nitrite in a subset of patients and carried out correlation analysis between plasma H2S and nitrite in these three groups. We found that plasma H2S was elevated in preeclampsia and further increased in gestational hypertension compared to healthy pregnancy. Plasma nitrite was reduced in gestational hypertension and preeclampsia, and these levels were negatively correlated with H2S in both gestational hypertension and preeclampsia, but not in healthy pregnancy. Our results indicate that increases in H2S may represent a mechanism triggered as an attempt to compensate reduced NO in gestational hypertension and preeclampsia. Future studies are warranted to investigate the mechanisms underlying H2S/NO interaction on mediating endothelial dysfunction in these hypertensive disorders of pregnancy.

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Maternal disease and gasotransmitters

Cited by 13 publications

References 154 publications

Retinal vessel diameters, flicker‐induced retinal vasodilation and retinal oxygen saturation in high‐ and low‐risk pregnancy

Retinal vessel diameters, flicker‐induced retinal vasodilation and retinal oxygen saturation in high‐ and low‐risk pregnancy

Gasotransmitters for the Therapeutic Prevention of Hypertension and Kidney Disease

Circulating levels of hydrogen sulphide negatively correlate to nitrite levels in gestational hypertensive and preeclamptic pregnant women

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