Circulating levels of hydrogen sulphide negatively correlate to nitrite levels in gestational hypertensive and preeclamptic pregnant women

Possomato-Vieira, José Sérgio; Palei, Ana C.; Pinto-Souza, Caroline C.; Cavalli, Ricardo de Carvalho; Dias‐Junior, Carlos A.; Sandrim, Valéria C.

doi:10.1111/1440-1681.13534

Cited by 6 publications

(3 citation statements)

References 44 publications

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“…Conversely, NO is also necessary for the maximal vasodilatory and angiogenic effects of hydrogen sulfide [ 185 ]. Instances of both lowered and elevated plasma hydrogen sulfide levels have been reported in preeclampsia [ 188 , 189 , 190 ]. This molecule can be separately synthesized by cystathionine β synthase (CBS), cystathionine γ lyase (CSE), and 3-mercaptopyruvate sulfurtransferase (MPST) [ 191 ].…”

Section: Endothelial Damage In Preeclampsiamentioning

confidence: 99%

Vascular Dysfunction in Preeclampsia

Opichka

Rappelt

Gutterman

et al. 2021

Cells

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Preeclampsia is a life-threatening pregnancy-associated cardiovascular disorder characterized by hypertension and proteinuria at 20 weeks of gestation. Though its exact underlying cause is not precisely defined and likely heterogenous, a plethora of research indicates that in some women with preeclampsia, both maternal and placental vascular dysfunction plays a role in the pathogenesis and can persist into the postpartum period. Potential abnormalities include impaired placentation, incomplete spiral artery remodeling, and endothelial damage, which are further propagated by immune factors, mitochondrial stress, and an imbalance of pro- and antiangiogenic substances. While the field has progressed, current gaps in knowledge include detailed initial molecular mechanisms and effective treatment options. Newfound evidence indicates that vasopressin is an early mediator and biomarker of the disorder, and promising future therapeutic avenues include mitigating mitochondrial dysfunction, excess oxidative stress, and the resulting inflammatory state. In this review, we provide a detailed overview of vascular defects present during preeclampsia and connect well-established notions to newer discoveries at the molecular, cellular, and whole-organism levels.

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Section: Endothelial Damage In Preeclampsiamentioning

confidence: 99%

Vascular Dysfunction in Preeclampsia

Opichka

Rappelt

Gutterman

et al. 2021

Cells

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“…However, these technical barriers are far from overcome. Publications reporting plasma concentrations of H 2 S in the middle to high micromolar range continue to emerge [17][18][19][20], which complicates data interpretation and comparisons between different laboratories. Plasma concentrations of H 2 S > 10 µM are an overestimation that hampers meaningful interpretation of H 2 S effects in physiology.…”

Section: Concentration Signaling and Cellular Response To H 2 Smentioning

confidence: 99%

Biosynthesis, Quantification and Genetic Diseases of the Smallest Signaling Thiol Metabolite: Hydrogen Sulfide

et al. 2021

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Hydrogen sulfide (H2S) is a gasotransmitter and the smallest signaling thiol metabolite with important roles in human health. The turnover of H2S in humans is mainly governed by enzymes of sulfur amino acid metabolism and also by the microbiome. As is the case with other small signaling molecules, disease-promoting effects of H2S largely depend on its concentration and compartmentalization. Genetic defects that impair the biogenesis and catabolism of H2S have been described; however, a gap in knowledge remains concerning physiological steady-state concentrations of H2S and their direct clinical implications. The small size and considerable reactivity of H2S renders its quantification in biological samples an experimental challenge. A compilation of methods currently employed to quantify H2S in biological specimens is provided in this review. Substantial discrepancy exists in the concentrations of H2S determined by different techniques. Available methodologies permit end-point measurement of H2S concentration, yet no definitive protocol exists for the continuous, real-time measurement of H2S produced by its enzymatic sources. We present a summary of available animal models, monogenic diseases that impair H2S metabolism in humans including structure-function relationships of pathogenic mutations, and discuss possible approaches to overcome current limitations of study.

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“…Extensive research has highlighted the signi cance of H 2 S in obstetrical and gynecological diseases, particularly in conditions like endometriosis(3) and gestational hypertension (14,15). These studies have emphasized the crucial role of H 2 S in mitigating in ammation, thereby contributing to the management of such gynecological ailments.…”

Section: Introductionmentioning

confidence: 99%

Unveiling the Role of SLC2A1 and MPST in Uterine Corpus Endometrial Carcinoma: Diagnostic and Prognostic Insights

Xi,

Gong,

Liu

et al. 2024

Preprint

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Background Uterine corpus endometrial carcinoma (UCEC) represents the prevailing neoplasm affecting the female reproductive system. The early diagnosis of UCEC is crucial for improving the survival rate of patients. In this study, we study the two specific genes: SLC2A1, which encodes the facilitated glucose transporter, and MPST, which encodes 3-mercaptopyruvate sulfurtransferase. SLC2A1 and MPST have been identified as important regulators in cancer. Nevertheless, it is still unknown how SLC2A1 and MPST function and operate within endometrial cancer. The objective of this study is to investigate the potential significance of SLC2A1 and MPST in terms of diagnosis and prognosis for UCEC. Methods Using data from the TCGA database, we analyzed the levels of expression for SLC2A1 and MPST in 33 various cancer types. Then we created a protein-protein interaction (PPI) network that incorporated SLC2A1, MPST, and relevant genes.Furthermore, we performed KEGG/GO pathway enrichment analysis on these genes. We utilized Spearman correlation analysis to examine the correlation between SLC2A1 and MPST expression and the infiltration of immune cells, as well as the association between immune checkpoint genes and TP53. We analyzed DNA methylation changes in the SLC2A1 and MPST genes and their impact on survival outcomes. We investigated the correlation between SLC2A1 and MPST expression and clinicopathological features of patients with endometrial cancer Additionally, we evaluated the diagnostic and prognostic predictive capabilities of SLC2A1 and MPST. Results In the tumor tissues, MPST and SLC2A1 expression levels increased significantly. Our research revealed a noteworthy association between the levels of expression of SLC2A1 and MPST, and the infiltration of immune cells, the presence of immune checkpoint genes, and TP53 in UCEC tissues. Furthermore, there was a remarkable association between the expression levels of SLC2A1 and MPST and the clinical stage, histological type, and histological grade in UCEC tissues. Our analysis using Kaplan-Meier survival curves and diagnostic subject operating characteristics (ROC) curves revealed that both SLC2A1 and MPST exhibit robust diagnostic and prognostic significance. Conclusions The study we conducted emphasizes the diagnostic and prognostic potential of SLC2A1 and MPST as biomarkers for UCEC. These findings offer encouraging prospects for targeted therapies.

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Circulating levels of hydrogen sulphide negatively correlate to nitrite levels in gestational hypertensive and preeclamptic pregnant women

Cited by 6 publications

References 44 publications

Vascular Dysfunction in Preeclampsia

Vascular Dysfunction in Preeclampsia

Biosynthesis, Quantification and Genetic Diseases of the Smallest Signaling Thiol Metabolite: Hydrogen Sulfide

Unveiling the Role of SLC2A1 and MPST in Uterine Corpus Endometrial Carcinoma: Diagnostic and Prognostic Insights

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