Maternal dietary protein restriction and excess affects offspring gene expression and methylation of non-SMC subunits of condensin I in liver and skeletal muscle

Altmann, Simone; Muráni, Eduard; Schwerin, Manfred; Metges, C. C.; Wimmers, Klaus; Ponsuksili, Siriluck

doi:10.4161/epi.7.3.19183

Cited by 67 publications

(51 citation statements)

References 70 publications

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“…LP maternal low-protein diet. The values shown represent the mean ± SEM, n = 7; *P \ 0.05 compared with the SP group; ***P \ 0.001 compared with the SP group myofiber CSA in the weaning piglets, which was consistent with previous observations in German Landrace pigs subjected to maternal protein restriction [5,30]. The phenotypic changes in muscle characteristics are often associated with metabolic alterations.…”

Section: Discussionsupporting

confidence: 88%

Maternal low-protein diet affects myostatin signaling and protein synthesis in skeletal muscle of offspring piglets at weaning stage

et al. 2014

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Section: Discussionsupporting

confidence: 88%

Maternal low-protein diet affects myostatin signaling and protein synthesis in skeletal muscle of offspring piglets at weaning stage

et al. 2014

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“…The mechanisms connecting protein in maternal diet to obesity and metabolic disease in offspring are not fully elucidated, but are believed to involve changes in gene expression through epigenetic alterations, such as DNA methylation [46]. Research in experimental animal models has provided compelling evidence to support a role for glucocorticoids in this process [11,20].…”

Section: Discussionmentioning

confidence: 99%

The Association between the Macronutrient Content of Maternal Diet and the Adequacy of Micronutrients during Pregnancy in the Women and Their Children’s Health (WATCH) Study

et al. 2012

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Nutrition during pregnancy can induce alterations in offspring phenotype. Maternal ratio of protein to non-protein (P:NP) energy has been linked to variations in offspring body composition and adult risk of metabolic disease. This study describes the dietary patterns of pregnant women by tertiles of the P:NP ratio and compares diet to Australian recommendations. Data are from 179 Australian women enrolled in the Women and Their Children’s Health Study. Diet was assessed using a validated 74-item food frequency questionnaire. Food group servings and nutrient intakes were compared to the Australian Guide to Healthy Eating and Australian Nutrient Reference Values. Higher maternal P:NP tertile was positively associated with calcium (P = 0.003), zinc (P = 0.001) and servings of dairy (P = 0.001) and meat (P = 0.001) food groups, and inversely associated with the energy dense, nutrient poor non-core (P = 0.003) food group. Micronutrient intakes were optimized with intermediate protein (18%E–20%E), intermediate fat (28%E–30%E) and intermediate carbohydrate (50%E–54%E) intakes, as indicated in tertile two. Results suggest a moderate protein intake may support pregnant women to consume the largest variety of nutrients across all food groups.

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“…The effect of famine significantly contributed to a range of abnormalities in newborns such as congenital neural defects, schizophrenia, and cerebro- and cardiovascular diseases [90,91,92]. Furthermore, several groups have reported that malnutrition during gestation causes epigenetic alteration in the offspring [93,94,95]. Dietary epigenetic regulators are critical in the process of normal fetal development in - utero, and an imbalance may cause irreversible phenotypic abnormalities in newborns [96,97].…”

Section: Maternal Lifestylementioning

confidence: 99%

Maternal Factors that Induce Epigenetic Changes Contribute to Neurological Disorders in Offspring

Banik

Kandilya

Ramya

et al. 2017

Genes

101

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It is well established that the regulation of epigenetic factors, including chromatic reorganization, histone modifications, DNA methylation, and miRNA regulation, is critical for the normal development and functioning of the human brain. There are a number of maternal factors influencing epigenetic pathways such as lifestyle, including diet, alcohol consumption, and smoking, as well as age and infections (viral or bacterial). Genetic and metabolic alterations such as obesity, gestational diabetes mellitus (GDM), and thyroidism alter epigenetic mechanisms, thereby contributing to neurodevelopmental disorders (NDs) such as embryonic neural tube defects (NTDs), autism, Down’s syndrome, Rett syndrome, and later onset of neuropsychological deficits. This review comprehensively describes the recent findings in the epigenetic landscape contributing to altered molecular profiles resulting in NDs. Furthermore, we will discuss potential avenues for future research to identify diagnostic markers and therapeutic epi-drugs to reverse these abnormalities in the brain as epigenetic marks are plastic and reversible in nature.

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Maternal dietary protein restriction and excess affects offspring gene expression and methylation of non-SMC subunits of condensin I in liver and skeletal muscle

Abstract: (2012) Maternal dietary protein restriction and excess affects offspring gene expression and methylation of non-SMC subunits of condensin I in liver and skeletal muscle, Epigenetics, 7:3, 239-252,

Cited by 67 publications

References 70 publications

Maternal low-protein diet affects myostatin signaling and protein synthesis in skeletal muscle of offspring piglets at weaning stage

Maternal low-protein diet affects myostatin signaling and protein synthesis in skeletal muscle of offspring piglets at weaning stage

The Association between the Macronutrient Content of Maternal Diet and the Adequacy of Micronutrients during Pregnancy in the Women and Their Children’s Health (WATCH) Study

Maternal Factors that Induce Epigenetic Changes Contribute to Neurological Disorders in Offspring

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