Maternal corticosterone effects on hypothalamus–pituitary–adrenal axis regulation and behavior of the offspring in rodents

Catalani, A.; Alemà, G; Cinque, Carlo; Zuena, Anna Rita; Casolini, Paola

doi:10.1016/j.neubiorev.2010.10.017

Cited by 96 publications

(89 citation statements)

References 219 publications

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“…As the postnatal maternal basal CORT level can directly influence her offspring through the milk she provides them (for review, see Catalani et al, 2011), thus providing a differential physiological context for the pups to respond to and recover from the novelty exposure, we expected and found that the direction and magnitude of the novelty exposure effect were indeed correlated with the maternal basal CORT measure on PND 33 (Fig. 4A,C) (T PREV_LOC_TRIAL1 : r s ϭ Ϫ0.554, p ϭ 0.009; OTR: r s ϭ Ϫ0.558, p ϭ 0.009).…”

Section: Resultsmentioning

confidence: 99%

Neonatal Novelty-Induced Persistent Enhancement in Offspring Spatial Memory and the Modulatory Role of Maternal Self-Stress Regulation

Tang

Reeb‐Sutherland²,

Yang³

et al. 2011

J. Neurosci.

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Development of spatial memory in the rat is influenced by both maternal and nonmaternal aspects of the postnatal environment. Yet it remains poorly understood how these two aspects of the postnatal environment interact to program offspring cognitive development. By considering the joint influence of neonatal environmental novelty and maternal self-stress regulation on the development of spatial memory function in Long-Evans hooded rats, we show a persistent neonatal novelty-induced enhancement in spatial reference and working memory functions among the same individual offspring from juvenility to adulthood and a contrasting transient maternal modulatory influence on this novelty-related enhancement present during only juvenility. Specifically, at and only at juvenility, for mothers with good self-stress regulation as indexed by a low circulating basal corticosterone level, offspring showed a novelty-induced enhancement in spatial memory function, whereas for mothers with poor self-stress regulation, indexed by a high basal corticosterone level, offspring showed little enhancement or even small impairments. These findings indicate that maternal and nonmaternal postnatal environments exert separate but interacting influences on offspring cognitive development and support a maternal modulation model of cognitive development that considers maternal self-stress regulation as an important factor among the multitude of maternal influences.

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Section: Resultsmentioning

confidence: 99%

Neonatal Novelty-Induced Persistent Enhancement in Offspring Spatial Memory and the Modulatory Role of Maternal Self-Stress Regulation

Tang

Reeb‐Sutherland²,

Yang³

et al. 2011

J. Neurosci.

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“…therefore, the present results suggested that the male Haa rats are predisposed to high anxiety compared with the male Laa rats. Previous studies demonstrated that Hatano strains have clear strain differences in the functions of the hypothalamo-pituitary-adrenal (HPa) axis [1,2,4], which has a pivotal role in physiologic response to stress, learning and anxiety-related status in animals [13,20,23,24,33,34,37,38]. corticotropinreleasing hormone (crH), arginine vasopressin (aVP) and prolactin are known as anxiety-related hormones [18,23,25,38].…”

Section: Discussionmentioning

confidence: 99%

Male Hatano High-Avoidance Rats Show High Avoidance and High Anxiety-Like Behaviors as Compared with Male Low-Avoidance Rats

et al. 2012

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Our prime objective was to establish an optimal model animal for studying avoidance learning and memory in rodents. The two-way rat inbred strains of Hatano high-(HAA) and lowavoidance (LAA) animals were originally selected and bred in accordance with their high or low performance respectively in the shuttle-box active avoidance task. Previous studies demonstrated that they have clear strain differences in endocrine stress response, which is related to acquisition of aversive learning and emotional reactivity. To evaluate the effect of selection by the shuttle-box task on avoidance performance and emotional reactivity, male Hatano rats underwent passive avoidance, open field and elevated plus maze tests. The present results show that the avoidance performance in the passive task was significantly greater in HAA rats than in LAA rats. Furthermore, HAA rats showed high anxiety-like behaviors compared with LAA rats in open field and elevated plus maze tests. Taken together, this study demonstrated that 1) selection and breeding of Hatano HAA and LAA strain rats by shuttle-box task had been properly carried out with the criterion of high and low avoidance performance respectively and that 2) HAA rats were predisposed to high anxiety compared with LAA rats. These results indicated that Hatano HAA and LAA rats can be useful models for studying avoidance learning and memory.

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“…We addressed this issue pharmacologically mimicking the every other day elevation of blood corticosterone caused by our protocol of FR. We treated a group of rats with a low dose of corticosterone in drinking water on alternate days for 4 weeks, as previously reported in rodents [26][27][28] , and we tested visual cortex plasticity evaluating the effects of 1 week of MD on OD distribution of cortical neurons. We found a significant shift of C/I VEP ratio in favour of the open eye in the visual cortex of MD rats treated with corticosterone (C/I VEP ratio = 1.22 ± 0.07; n = 5; one-way ANOVA P < 0.001; post hoc HolmSidak test CTL versus FR P < 0.001; CTL versus Cort P < 0.001; Cort versus FR P = 0.826; Fig.…”

Section: Corticosterone Mimics Fr Effects On Visual Cortex Plasticitymentioning

confidence: 99%

Food restriction enhances visual cortex plasticity in adulthood

Spolidoro¹,

Baroncelli²,

Putignano

et al. 2011

Nat Commun

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neural circuits display a heightened sensitivity to external stimuli during well-established windows in early postnatal life. After the end of these critical periods, brain plasticity dramatically wanes. The visual system is one of the paradigmatic models for studying experiencedependent plasticity. Here we show that food restriction can be used as a strategy to restore plasticity in the adult visual cortex of rats. A short period of food restriction in adulthood is able both to reinstate ocular dominance plasticity and promote recovery from amblyopia. These effects are accompanied by a reduction of intracortical inhibition without modulation of brainderived neurotrophic factor expression or extracellular matrix structure. our results suggest that food restriction could be investigated as a potential way of modulating plasticity.

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Maternal corticosterone effects on hypothalamus–pituitary–adrenal axis regulation and behavior of the offspring in rodents

Cited by 96 publications

References 219 publications

Neonatal Novelty-Induced Persistent Enhancement in Offspring Spatial Memory and the Modulatory Role of Maternal Self-Stress Regulation

Neonatal Novelty-Induced Persistent Enhancement in Offspring Spatial Memory and the Modulatory Role of Maternal Self-Stress Regulation

Male Hatano High-Avoidance Rats Show High Avoidance and High Anxiety-Like Behaviors as Compared with Male Low-Avoidance Rats

Food restriction enhances visual cortex plasticity in adulthood

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