Maternal control of early mouse development

Li, Lei; Zheng, Ping; Dean, Jurrien

doi:10.1242/dev.039487

Cited by 390 publications

(345 citation statements)

References 120 publications

Supporting

Mentioning

317

Contrasting

Unclassified

Order By: Relevance

“…Esto sugiere que la IVM modifica el microambiente del ovocito, al ocasionar un cambio celular y genético que impide que esta célula se desarrolle de manera normal (10) . Desde folículo primordial hasta el folículo preantral, el ovocito almacena transcritos (11) , cuya traducción genera proteínas que son claves para su maduración (12) y, después de ser fertilizado, para su transición hacia el embrión (13) .…”

Section: Introductionunclassified

“…This suggests that the IVM modifies the microenvironment of the oocyte, to cause cellular and genetic change that prevents this cell to develop as normal (10) . From primordial follicle until the preantral follicle the oocyte stores transcripts (11) , whose translation produces proteins that are key to its maturation (12) and, after being fertilized, for its transition to the embryo (13) .…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Efectos de los RNAm maternos sobre la maduración del ovocito y el desarrollo embrionario temprano en mamíferos

Burrola-Barraza¹,

González-Rodríguez

2015

Rev. Mex. Cienc. Pecu.

View full text Add to dashboard Cite

Efectos de los RNAm maternos sobre la maduración del ovocito y el desarrollo embrionario temprano en mamíferos. RevisiónEffects of the maternal mRNA on the maturation of the oocyte and early embryonic development in mammals. Review M. Eduviges Burrola-Barraza a , Everardo González-Rodríguez a RESUMENObtener ovocitos madurados in vitro, que sean competentes para fertilizarse y originar un porcentaje superior al 50 % de blastocitos viables, es una de las principales metas que existen en el desarrollo in vitro de embriones bovinos. Es por ello necesario entender los procesos celulares, que desembocan en la maduración del ovocito durante la foliculogénesis y su subsecuente transición al embrión. La transición del ovocito al embrión es un proceso complejo que involucra la inactivación genómica del ovocito y la activación del genoma embrionario. Este proceso se da en bovinos en la etapa de 8 a 16 células y presenta una degradación selectiva de RNAm maternos, que fueron almacenados durante la ovogénesis y son la fuente para la codificación de proteínas en las etapas iníciales del desarrollo embrionario. La acción de los RNAm maternos es clave para que la activación del genoma embrionario se realice en tiempo y forma adecuados. Entender la participación de estos transcritos en la activación del genoma embrionario, es esencial para esclarecer los procesos celulares que fallan en los protocolos de maduración de ovocitos in vitro. Es por esto que el objetivo de esta revisión fue recopilar la información de los principales RNAm maternos que han sido identificados tanto en el modelo murino como el bovino, esto con el fin de integrar el conocimiento relacionado con los procesos genómicos que permiten el desarrollo del embrión en el bovino, y diseñar nuevas estrategias que permitan mejorar los protocolos de fertilización in vitro.PALABRAS CLAVE: Ovocito, Activación genoma embrionario, Bovino. ABSTRACTGet in vitro matured oocytes that could be competent for in vitro fertilization with a result of 50 % viable blastocysts, is one of the main problems in the in vitro development of bovine embryos. For these reason, is necessary to understand the cellular processes that lead to the maturation of the oocyte during folliculogenesis and subsequent transition to the embryo. The transition from oocyte to embryo is a complex process that involves genomic inactivation of the oocyte and embryonic genome activation. This process occurs in cattle in the stage of 8 to 16 cells where there are a selective degradation of maternal mRNA, which were stored during oogenesis and are the source of protein in the early stages of embryonic development. The action of maternal mRNA is a key for that embryonic genome activation takes place in form and time. Understanding the involvement of these transcripts in embryonic genome activation is essential to elucidate the cellular processes falling in oocyte maturation in vitro protocols. The aim of this review was to gather information from maternal genes that have been isolated both in the murine model and c...

show abstract

Section: Introductionunclassified

Section: Introductionmentioning

confidence: 99%

Efectos de los RNAm maternos sobre la maduración del ovocito y el desarrollo embrionario temprano en mamíferos

Burrola-Barraza¹,

González-Rodríguez

2015

Rev. Mex. Cienc. Pecu.

View full text Add to dashboard Cite

show abstract

“…Preimplantation development is regulated by the synergic action of cytoplasmic and nuclear determinants inherited by the egg and acquired during the oocyte growth: mRNAs, small interfering RNAs (siRNAs) and transcription factors are all required to regulate the expression of the female genome during these early stages. When the expression of one of the 27 maternal-effect factors identified so far is altered, mouse embryos arrest development, mostly at the 2-cell stage (for a review see [13]). We have recently shown that one of the possible causes of the developmental incompetence of MII NSN oocytes is the down-regulation of two maternaleffect factors, OCT4 and STELLA [27,28], required for development beyond the 2-cell stage [8,20].…”

Section: Introductionmentioning

confidence: 99%

Fully-mature antral mouse oocytes are transcriptionally silent but their heterochromatin maintains a transcriptional permissive histone acetylation profile

Zuccotti

Bellone

Longo

et al. 2011

J Assist Reprod Genet

View full text Add to dashboard Cite

Purpose The final stages of antral mouse oocytes maturation are characterised by the transition from transcriptionally active NSN to inactive SN oocytes. Here, we studied the profile of histone acetylation changes occurring during the NSN-to-SN transition. Methods During the NSN-to-SN transition, oocytes were classified based on their chromatin organisation and the immunocytochemical profile of histones H2B, H3 and H4 acetylation was analysed. Results We described four patterns of immunostaining common to the three acetylated histones, corresponding to stages of progressive localisation: From a diffused distribution in NSN oocytes to the association with constitutive heterochromatin and then to the nucleolar surface region in SN oocytes. Conclusions The maintenance of a favourable transcriptional epigenetic context, in the heterochromatin of transcriptionally silent SN oocytes, might be related to the early stages of development when transcripts from these heterochromatic regions are functional to preimplantation progression.Keywords Mouse . Antral oocytes . Chromatin organisation . Histone acetylation Capsule In late antral mouse oocytes, chromatin condenses around the nucleolus, becomes transcriptionally silent, but maintains transcriptionally permissive histone acetylation profiles, likely functional to development.

show abstract

“…11 Proteins are also targeted for degradation during early development through the ubiquitinproteasome pathway and macroautophagy (see reviews 12,13 ).…”

mentioning

confidence: 99%