Maternal consumption of high-fat diet and grape juice modulates global histone H4 acetylation levels in offspring hippocampus: A preliminary study

Gonçalves, Luciana Kneib; Silva, Ivy Reichert Vital da; Cechinel, Laura Reck; Frusciante, Marina Rocha; Mello, Alexandre Silva de; Elsner, Viviane Rostirola; Funchal, Cláudia; Dani, Caroline

doi:10.1016/j.neulet.2017.09.042

Cited by 13 publications

(7 citation statements)

References 34 publications

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“…Indeed, specific combinations of nutritional factors may affect the outcomes of a given exposure. For instance, the beneficial effects of grape polyphenols are ameliorated by the presence of high-fat diets [29]. In this study, the maternal intake of olive oil contributed to more pronounced effects on the H3 acetylation levels in the placentas of anthroposophic families in comparison with non-anthroposophic families (Figure 2).…”

Section: Resultsmentioning

confidence: 54%

Histone Acetylation of Immune Regulatory Genes in Human Placenta in Association with Maternal Intake of Olive Oil and Fish Consumption

Acevedo

Frumento

Harb

et al. 2019

IJMS

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Maternal diet modifies epigenetic programming in offspring, a potentially critical factor in the immune dysregulation of modern societies. We previously found that prenatal fish oil supplementation affects neonatal T-cell histone acetylation of genes implicated in adaptive immunity including PRKCZ, IL13, and TBX21. In this study, we measured H3 and H4 histone acetylation levels by chromatin immunoprecipitation in 173 term placentas collected in the prospective birth cohort, ALADDIN, in which information on lifestyle and diet is thoroughly recorded. In anthroposophic families, regular olive oil usage during pregnancy was associated with increased H3 acetylation at FOXP3 (p = 0.004), IL10RA (p = 0.008), and IL7R (p = 0.007) promoters, which remained significant after adjustment by offspring gender. Furthermore, maternal fish consumption was associated with increased H4 acetylation at the CD14 gene in placentas of female offspring (p = 0.009). In conclusion, prenatal olive oil intake can affect placental histone acetylation in immune regulatory genes, confirming previously observed pro-acetylation effects of olive oil polyphenols. The association with fish consumption may implicate ω-3 polyunsaturated fatty acids present in fish oil. Altered histone acetylation in placentas from mothers who regularly include fish or olive oil in their diets could influence immune priming in the newborn.

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Section: Resultsmentioning

confidence: 54%

Histone Acetylation of Immune Regulatory Genes in Human Placenta in Association with Maternal Intake of Olive Oil and Fish Consumption

Acevedo

Frumento

Harb

et al. 2019

IJMS

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“…The resulting compounds can subsequently exert epigenetic effects on the host, for instance, DNA methyltransferase (DNMT) inhibition by resveratrol, HDAC inhibition by sulforaphane, histone acetyltransferase (HAT) inhibition by (-)-epigallocatechin-3-gallate (EGCG) in green tea, as well as regulation of miRNAs by genistein [47]. Beneficial effects of the perinatal supplementation of polyphenols mediated through the epigenetic changes triggered by them in the host have been observed, such as contribution to chronic disease prevention [279] and the modulation of the central nervous system development [277,280]. Similar roles of polyphenols have been suggested for allergies as well [281].…”

Section: Bacteriamentioning

confidence: 99%

Perinatal and Early-Life Nutrition, Epigenetics, and Allergy

et al. 2021

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Epidemiological studies have shown a dramatic increase in the incidence and the prevalence of allergic diseases over the last several decades. Environmental triggers including risk factors (e.g., pollution), the loss of rural living conditions (e.g., farming conditions), and nutritional status (e.g., maternal, breastfeeding) are considered major contributors to this increase. The influences of these environmental factors are thought to be mediated by epigenetic mechanisms which are heritable, reversible, and biologically relevant biochemical modifications of the chromatin carrying the genetic information without changing the nucleotide sequence of the genome. An important feature characterizing epigenetically-mediated processes is the existence of a time frame where the induced effects are the strongest and therefore most crucial. This period between conception, pregnancy, and the first years of life (e.g., first 1000 days) is considered the optimal time for environmental factors, such as nutrition, to exert their beneficial epigenetic effects. In the current review, we discussed the impact of the exposure to bacteria, viruses, parasites, fungal components, microbiome metabolites, and specific nutritional components (e.g., polyunsaturated fatty acids (PUFA), vitamins, plant- and animal-derived microRNAs, breast milk) on the epigenetic patterns related to allergic manifestations. We gave insight into the epigenetic signature of bioactive milk components and the effects of specific nutrition on neonatal T cell development. Several lines of evidence suggest that atypical metabolic reprogramming induced by extrinsic factors such as allergens, viruses, pollutants, diet, or microbiome might drive cellular metabolic dysfunctions and defective immune responses in allergic disease. Therefore, we described the current knowledge on the relationship between immunometabolism and allergy mediated by epigenetic mechanisms. The knowledge as presented will give insight into epigenetic changes and the potential of maternal and post-natal nutrition on the development of allergic disease.

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“…Although many works have looked at the epigenetic changes induced by mHFD in the programming of peripheral metabolic diseases, very few studies have looked at the consequences in the CNS of the offspring ( Gawlińska et al, 2021a ). For instance, it has been reported that consumption of a high-fat diet during gestation and lactation in the Wistar rat decreases the global level of histone H4 acetylation in the hippocampus at P50, leading to transcriptional repression ( Gonçalves et al, 2017 ). Interestingly, a diet rich in grape juice has an opposite effect on the level of this epigenetic mark at PND21 and is associated with a beneficial effect on the brain with an antioxidant effect ( Gonçalves et al, 2017 ; Schaffer et al, 2019 ) which could limit deleterious consequences of mHFD by reducing oxidative stress and acetylcholinesterase activity ( Proença et al, 2021 ).…”

Section: Long-term Consequences Of Early Environment On Tau and Aβmentioning

confidence: 99%

“…For instance, it has been reported that consumption of a high-fat diet during gestation and lactation in the Wistar rat decreases the global level of histone H4 acetylation in the hippocampus at P50, leading to transcriptional repression ( Gonçalves et al, 2017 ). Interestingly, a diet rich in grape juice has an opposite effect on the level of this epigenetic mark at PND21 and is associated with a beneficial effect on the brain with an antioxidant effect ( Gonçalves et al, 2017 ; Schaffer et al, 2019 ) which could limit deleterious consequences of mHFD by reducing oxidative stress and acetylcholinesterase activity ( Proença et al, 2021 ). However, to our knowledge, the putative consequences of mHFD on epigenetic changes in MAPT and AβPP genes have never been reported.…”

Section: Long-term Consequences Of Early Environment On Tau and Aβmentioning

confidence: 99%

Early-Life Environment Influence on Late-Onset Alzheimer’s Disease

Gauvrit

Benderradji

Buée

et al. 2022

Front. Cell Dev. Biol.

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With the expand of the population’s average age, the incidence of neurodegenerative disorders has dramatically increased over the last decades. Alzheimer disease (AD) which is the most prevalent neurodegenerative disease is mostly sporadic and primarily characterized by cognitive deficits and neuropathological lesions such as amyloid -β (Aβ) plaques and neurofibrillary tangles composed of hyper- and/or abnormally phosphorylated Tau protein. AD is considered a complex disease that arises from the interaction between environmental and genetic factors, modulated by epigenetic mechanisms. Besides the well-described cognitive decline, AD patients also exhibit metabolic impairments. Metabolic and cognitive perturbations are indeed frequently observed in the Developmental Origin of Health and Diseases (DOHaD) field of research which proposes that environmental perturbations during the perinatal period determine the susceptibility to pathological conditions later in life. In this review, we explored the potential influence of early environmental exposure to risk factors (maternal stress, malnutrition, xenobiotics, chemical factors … ) and the involvement of epigenetic mechanisms on the programming of late-onset AD. Animal models indicate that offspring exposed to early-life stress during gestation and/or lactation increase both AD lesions, lead to defects in synaptic plasticity and finally to cognitive impairments. This long-lasting epigenetic programming could be modulated by factors such as nutriceuticals, epigenetic modifiers or psychosocial behaviour, offering thus future therapeutic opportunity to protect from AD development.

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Maternal consumption of high-fat diet and grape juice modulates global histone H4 acetylation levels in offspring hippocampus: A preliminary study

Cited by 13 publications

References 34 publications

Histone Acetylation of Immune Regulatory Genes in Human Placenta in Association with Maternal Intake of Olive Oil and Fish Consumption

Histone Acetylation of Immune Regulatory Genes in Human Placenta in Association with Maternal Intake of Olive Oil and Fish Consumption

Perinatal and Early-Life Nutrition, Epigenetics, and Allergy

Early-Life Environment Influence on Late-Onset Alzheimer’s Disease

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