Maternal Comorbidities and Complications of Delivery in Pregnant Women With Congenital Heart Disease

Schlichting, Lauren E.; Insaf, Tabassum Z.; Zaidi, Ali N.; Lui, George K.; Zutphen, Alissa R. Van

doi:10.1016/j.jacc.2019.01.069

Cited by 64 publications

(56 citation statements)

References 19 publications

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“…Patients with pre-eclampsia often suffer from increased uric acid levels and serum transaminase concentrations (24). Currently, the only effective treatment for pre-eclampsia is delivery or interruption of pregnancy (25). The pathogenesis of pre-eclampsia remains elusive.…”

Section: Discussionmentioning

confidence: 99%

Long non‑coding RNA NR_002794 is upregulated in pre‑eclampsia and regulates the proliferation, apoptosis and invasion of trophoblast cells

Liang

et al. 2019

Mol Med Report

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Pre-eclampsia is a common complication during pregnancy, characterized by hypertension and proteinuria. The pathogenesis of pre-eclampsia is not fully understood. Studies on the maternal spiral artery have led scientists to consider that the ineffective infiltration of placental trophoblast cells may be a primary cause of pre-eclampsia. The present study aimed to investigate the differences in the profiles of long non-coding RNAs (lncRNAs) between the placentas of patients with pre-eclampsia and those of healthy pregnant women. The involvement of the differentially expressed lncRNAs in the biological activity of trophoblast cells was also assessed. A total of 26 differentially expressed lncRNAs were identified between the pre-eclampsia and healthy groups. Upregulation of NR_002794 was found in tissues from patients with pre-eclampsia. In SWAN71 trophoblast cells, NR_002794 had suppressive effects on proliferation and migration, and resulted in an increased rate of apoptosis. Furthermore, lncRNA NR_002794 had no effect on the phagocytosis of trophoblast cells. The present study suggested that abnormal levels of NR_002794 may lead to atypical conditions in trophoblast cells, which may be associated with the failure of maternal spiral artery remodeling during pregnancy and, consequently, with the development of pre-eclampsia.

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Section: Discussionmentioning

confidence: 99%

Long non‑coding RNA NR_002794 is upregulated in pre‑eclampsia and regulates the proliferation, apoptosis and invasion of trophoblast cells

Liang

et al. 2019

Mol Med Report

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“…The rate of deliveries of pregnant women with CHD rises by 34.9% over 10-years period (1998–2007) which is explained by the advance diagnostic, medical and surgical management and care leading to improve the survival of more than 90% patients with CHD, reaching the reproductive age even those with more complex CHD [15–18]. However, pregnant women with CHD are more prone to develop cardiovascular and adverse obstetric and fetal complications, even the simple CHD can hold high pregnancy risk if their condition is associated with other comorbid disease [15, 17, 18]. Fortunately, most of these complications can be managed and the rate of mortality is rare [10, 16].…”

Section: Discussionmentioning

confidence: 99%

Heart disease in pregnancy—clinical pattern and prevalence: initial data from the first cardio-maternal unit in Iraq

Farhan

Yaseen

2019

BMC Res Notes

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Objectives The purpose of this study to determine the clinical pattern and prevalence of heart disease in pregnancy at the first established cardio-maternal unit in Iraq over the last 4 years; since January 2015 till May 2019. Data are presented as number and percentage. Results A total of 252 pregnant women presented to cardio-maternal unit included in this study. According to the collected data, among the main diagnosis of heart disease during pregnancy was valvular heart disease 34.1%, followed by congenital heart disease 30.5%, cardiomyopathy 29.8%, pulmonary hypertension 4%, and ischemic heart disease 1.6%. Among subtypes of the main heart diseases in pregnant women, the most clinical pattern was: the prosthetic heart valve (26.7%) in valvular heart disease, both atrial septal defect and ventricular septal defect (35%) in congenital heart disease, and peripartum cardiomyopathy (76%) among cardiomyopathies.

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“…including HF, arrhythmia, and thromboembolic events, during delivery are 2.4-to 27.6-fold higher for women with than without CHD. 3 Since the late 1980s, an alternative to the atrial switch has been an arterial switch, which is now performed more frequently. 14 aneurysm of the neoaortic valve is recommended.…”

Section: Case 1: Prepregnancy Evaluation Of a Woman With Bicuspid Aormentioning

confidence: 99%

Pregnancy in Women with Congenital Heart Disease: A Guide for the General Cardiologist

Weinberg

Ahmad²,

Li³

et al. 2020

US Cardiology Review

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Remarkable advances in the care and survival of congenital heart disease (CHD) patients have led to increasing numbers of young women with CHD who carry a pregnancy with significant risk. The profound hemodynamic changes that naturally occur during gestation may unmask CHD or exacerbate an existing condition and place both the woman and fetus in jeopardy. The caring cardiologist should be familiar with the specific lesion and anticipate complications. Pregestational counseling and a multidisciplinary team approach during pregnancy are key for a successful pregnancy and favorable outcomes. In this review we discuss the evaluation of the expecting CHD patient and focus on the commonly encountered lesions.

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Maternal Comorbidities and Complications of Delivery in Pregnant Women With Congenital Heart Disease

Cited by 64 publications

References 19 publications

Long non‑coding RNA NR_002794 is upregulated in pre‑eclampsia and regulates the proliferation, apoptosis and invasion of trophoblast cells

Long non‑coding RNA NR_002794 is upregulated in pre‑eclampsia and regulates the proliferation, apoptosis and invasion of trophoblast cells

Heart disease in pregnancy—clinical pattern and prevalence: initial data from the first cardio-maternal unit in Iraq

Pregnancy in Women with Congenital Heart Disease: A Guide for the General Cardiologist

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