Maternal Bone Lead as an Independent Risk Factor for Fetal Neurotoxicity: A Prospective Study

Gomaa, Ahmed; Hu, Howard; Bellinger, David C.; Schwartz, Joel; Tsaih, Shirng‐Wern; González-Cossı́o, Teresa; Schnaas, Lourdes; Peterson, Karen E.; Aro, Antonio; Hernández-Ávila, Mauricio

doi:10.1542/peds.110.1.110

Cited by 137 publications

(102 citation statements)

References 28 publications

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“…The major source of fetal lead is believed to be maternal bone. Even in the absence of lead in the external environment, the long resident time of lead in trabecular (3 years) and cortical bone (30 years) exposes the fetus to contamination [6], and demineralisation during pregnancy mobilises the lead from maternal bone stores [3]. Our study confirms that despite the reduction of lead in the environment by discontinuing leaded petrol [7], the problem of fetal lead exposure has not been eradicated.…”

Section: Umbilical Cord Blood Lead Levelssupporting

confidence: 67%

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Umbilical cord blood lead levels

Senanayake¹,

Rodrigo

2011

Ceylon Med. J.

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Section: Umbilical Cord Blood Lead Levelssupporting

confidence: 67%

“…Even low blood lead concentrations affect intelligence [1,2]. It is an independent, significant and inversely related risk factor for mental development in the first two years [3,4].…”

Section: Umbilical Cord Blood Lead Levelsmentioning

confidence: 99%

Umbilical cord blood lead levels

Senanayake¹,

Rodrigo

2011

Ceylon Med. J.

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“…The standard average for each one is 100 ± 15 (1 SD) points. This study used the version translated into Spanish previously used in Mexico (Gomaa et al, 2002;Hu et al, 2006;Torres-Sa´nchez et al, 2007). We evaluated interexaminer reliability by calculating the correlation in MDI and PDI scores between the testing and observing psychologists with 10 subjects.…”

Section: Graham-rosenblith Scale Only the Neurological Softmentioning

confidence: 99%

Neonatal neurodevelopment and prenatal exposure to dichlorodiphenyldichloroethylene (DDE): A cohort study in Mexico

Bahena-Medina

Torres‐Sánchez

Schnaas

et al. 2011

J Expo Sci Environ Epidemiol

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Prenatal exposure to dichlorodiphenyldichloroethylene (DDE) is associated with decreased motor development during the first year of life, though the effects of DDE in the neonatal stage are not conclusive. The main aim of this study was to evaluate the association between prenatal DDE exposure and neonatal neurodevelopment in a cohort from four municipalities in the state of Morelos, Mexico. The children (265), born from pregnancies with no perinatal complications, were evaluated at 1 month of age (±7 days) for the presence of abnormal reflexes with the Brazelton Scale (NBAS), neurological soft signs with the Graham-Rosenblith Scale, as well as mental and psychomotor development by the Bayley Scales of Infant Development. Maternal DDE concentrations during each trimester of the pregnancy were determined by gas chromatography. Multiple linear and ordinal logistic models assessed the association between DDE and the outcomes of interest. Prenatal exposure to DDE was associated with a non-significant increase in neurological soft signs (6-8%) and a decrease in psychomotor (b 1T ¼ À0.02) and mental (b 2T ¼ À0.03 and b 3T ¼ À0.19) development. Our results are consistent with previous studies and suggest that prenatal DDE exposure is not associated with neurological functions present in the neonatal stage.

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“…Calcium deficiency increases lead absorption and lead retention, and is a risk factor for increased maternal lead transfer. In which, Methyl mercury crosses the placenta and reaches the fetus, and is concentrated in the fetal brain at least 5 to 7 times that of maternal blood [82][83][84][85][86]. Prenatal methyl mercury exposure at high levels can induce widespread damage to the fetal brain.…”

Section: The Toxicity Of Leadmentioning

confidence: 99%

A Review of the Potential Issues of Pollution Caused by the Mineral Elements, Mercury, Lead and Arsenic, Its Possible Impacts on the Human Beings and the Suggested Solutions

Lam¹,

Sze²,

Yao³

et al. 2012

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Objective: This paper mainly discusses and summarises the potential issues of pollution caused by the Mineral elements, Mercury, Lead and Arsenic, its possible impacts on the human beings and the suggested solutions. Methods: This paper is prepared by reviewing the latest academic literatures. Result: First, this article discusses two aspects including the effects of Mercury, Lead and Arsenic on the Chinese herbal medicine and the potential issues of causing the environmental pollution. And then further study its toxicity effects and the side impacts on the human bodies in order to realize the actual circumstances people are encountering nowadays. This paper will also the corresponding its treatment method of reviews. Hope this will provide a valuable reference. Conclusion: Theses issues caused by the Mineral elements are prominent nowadays, thus the ongoing researches on the impacts of pollution and the possible solutions are regarded as highly valued in order to conserve the natural environment and meanwhile safeguard the well beings of people and the future offspring.

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Maternal Bone Lead as an Independent Risk Factor for Fetal Neurotoxicity: A Prospective Study

Cited by 137 publications

References 28 publications

Umbilical cord blood lead levels

Umbilical cord blood lead levels

Neonatal neurodevelopment and prenatal exposure to dichlorodiphenyldichloroethylene (DDE): A cohort study in Mexico

A Review of the Potential Issues of Pollution Caused by the Mineral Elements, Mercury, Lead and Arsenic, Its Possible Impacts on the Human Beings and the Suggested Solutions

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