Neonatal neurodevelopment and prenatal exposure to dichlorodiphenyldichloroethylene (DDE): A cohort study in Mexico

Bahena-Medina, Lilia Araceli; Torres‐Sánchez, Luisa; Schnaas, Lourdes; Cebrián, Mariano E.; Chavez, Carmen; Osorio-Valencia, Erika; Hernández, Rosa María García; López‐Carrillo, Lizbeth

doi:10.1038/jes.2011.25

Cited by 28 publications

(20 citation statements)

References 13 publications

(25 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The results of this study on DDT/DDE were somewhat unexpected, given our previous findings in the Center for the Health Assessment of Mothers and Children of Salinas (CHAMACOS) birth cohort study ( Eskenazi et al. 2006 ) as well as those of others ( Bahena-Medina et al. 2011 ; Ribas-Fitó et al.…”

Section: Discussioncontrasting

confidence: 65%

Prenatal Exposure to DDT and Pyrethroids for Malaria Control and Child Neurodevelopment: The VHEMBE Cohort, South Africa

Eskenazi

Rauch

et al. 2018

Environ Health Perspect

View full text Add to dashboard Cite

Background:Although indoor residual spraying (IRS) with dichlorodiphenyltrichloroethane (DDT) and pyrethroids effectively controls malaria, it potentially increases human exposure to these insecticides. Previous studies suggest that prenatal exposure to these insecticides may impact human neurodevelopment.Objectives:We aimed to estimate the effects of maternal insecticide exposure and neurodevelopment of toddlers living in a malaria-endemic region currently using IRS.Methods:The Venda Health Examination of Mothers, Babies and their Environment (VHEMBE) is a birth cohort of 752 mother–child pairs in Limpopo, South Africa. We measured maternal exposure to DDT and its breakdown product, dichlorodiphenyldichloroethylene (DDE), in maternal serum, and measured pyrethroid metabolites in maternal urine. We assessed children’s neurodevelopment at 1 and 2 y of age using the Bayley Scales of Infant Development, third edition (BSID-III), and examined associations with maternal exposure.Results:DDT and DDE were not associated with significantly lower scores for any BSID-III scale. In contrast, each 10-fold increase in cis-DCCA, trans-DCCA, and 3-phenoxybenzoic acid were associated, respectively, with a −0.63 (95% CI: −1.14, −0.12), −0.48 (95% CI: −0.92, −0.05), and −0.58 (−1.11, −0.06) decrement in Social-Emotional scores at 1 y of age. In addition, each 10-fold increase in maternal cis-DBCA levels was associated with significant decrements at 2 y of age in Language Composite scores and Expressive Communication scores [β=−1.74 (95% CI: −3.34, −0.13) and β=−0.40 (95% CI: −0.77, −0.04), respectively, for a 10-fold increase]. Significant differences by sex were estimated for pyrethroid metabolites and motor function scores at 2 y of age, with higher scores for boys and lower scores for girls.Conclusions:Prenatal exposure to pyrethroids may be associated at 1 y of age with poorer social-emotional development. At 2 y of age, poorer language development was observed with higher prenatal pyrethroid levels. Considering the widespread use of pyrethroids, these findings deserve further investigation. https://doi.org/10.1289/EHP2129

show abstract

Section: Discussioncontrasting

confidence: 65%

Prenatal Exposure to DDT and Pyrethroids for Malaria Control and Child Neurodevelopment: The VHEMBE Cohort, South Africa

Eskenazi

Rauch

et al. 2018

Environ Health Perspect

View full text Add to dashboard Cite

show abstract

“…Breastfeeding seemed to be associated with higher cognitive scores among a Mexican cohort in which scores were measured periodically over the child’s first year of life. The beneficial effects associated with breastfeeding were not apparent as early as the first month of life ( P univ >0.05) [ 140 ]. However, breastfeeding over a child’s first year of life was a positive predictor of cognitive development from one to twelve months old independent of prenatal pesticide exposure (B = 1.14, P = 0.03) [ 141 ].…”

Section: Resultsmentioning

confidence: 99%

Contributions of a Child’s Built, Natural, and Social Environments to Their General Cognitive Ability: A Systematic Scoping Review

2016

View full text Add to dashboard Cite

The etiology of a child’s cognitive ability is complex, with research suggesting that it is not attributed to a single determinant or even a defined period of exposure. Rather, cognitive development is the product of cumulative interactions with the environment, both negative and positive, over the life course. The aim of this systematic scoping review was to collate evidence associated with children’s cognitive health, including inherent factors as well as chemical and non-chemical stressors from the built, natural, and social environments. Three databases were used to identify recent epidemiological studies (2003–2013) that examined exposure factors associated with general cognitive ability in children. Over 100 factors were evaluated from 258 eligible studies. We found that recent literature mainly assessed the hypothesized negative effects of either inherent factors or chemical exposures present in the physical environment. Prenatal growth, sleep health, lead and water pollutants showed consistent negative effects. Of the few studies that examined social stressors, results consistently showed cognitive development to be influenced by both positive and negative social interactions at home, in school or the community. Among behavioral factors related to diet and lifestyle choices of the mother, breastfeeding was the most studied, showing consistent positive associations with cognitive ability. There were mostly inconsistent results for both chemical and non-chemical stressors. The majority of studies utilized traditional exposure assessments, evaluating chemical and non-chemical stressors separately. Collective evidence from a limited number of studies revealed that cumulative exposure assessment that incorporates multiple chemical and non-chemical stressors over the life course may unravel the variability in effect on cognitive development and help explain the inconsistencies across studies. Future research examining the interactions of multiple stressors within a child’s total environment, depicting a more real-world exposure, will aid in understanding the cumulative effects associated with a child’s ability to learn.

show abstract

“…(Eskenazi et al, 2006; Jacobson and Jacobson, 1996; Jacobson and Jacobson, 2003; Jacobson et al, 1985; Park et al, 2010; Patandin et al, 1999; Stewart et al, 2000; Stewart et al, 2008; Torres-Sanchez et al, 2007)), though not all (i.e. (Bahena-Medina et al, 2011; Fenster et al, 2007; Gray et al, 2005; Winneke et al, 1998)) studies. While associations reported have primarily focused on general developmental or cognitive measures, studies examining biomarkers of exposure to PCBs, DDT or PBDE, specifically, and autism have not to our knowledge been reported.…”

Section: Introductionmentioning

confidence: 98%

Maternal serum persistent organic pollutants in the Finnish Prenatal Study of Autism: A pilot study

Cheslack‐Postava

Rantakokko

Hinkka‐Yli‐Salomäki

et al. 2013

Neurotoxicology and Teratology

View full text Add to dashboard Cite

Recent research emphasizes the contribution of environmental as well as genetic factors to the etiology of autism but studies testing associations between chemical exposures and autism have been limited. Prenatal exposure to persistent organic pollutants (POPs) has previously been associated with decrements in cognitive and developmental performance. We conducted a pilot study in the Finnish Prenatal Study of Autism (FiPS-A). Seventy-five cases with autism and 75 controls matched on sex, birth year, urbanization and maternal age were sampled from first-born children in the Finnish Maternity Cohort, which includes over 1 million births. The study sample included births occurring from 1991 to 2000. Subjects were followed up for autism through 2007. DDT, DDE, PCB-118, PCB-138, PCB-153, PCB-156, PCB-170, PCB-180, hexachlorobenzene, and BDE-47 were measured in archived maternal serum samples taken during pregnancy using gas chromatography-high resolution mass spectrometry. Correlations between pollutant measures were assessed and mechanistically-related weighting schemes for summarizing PCB levels were compared. Case and control differences were assessed using graphical and statistical methods. All analytes, with the exception of DDT and BDE-47, were detected above the limit of quantification in all samples. The correlation between levels of individual PCB congeners and weighted summary measures was high (0.71-1.00). Paired t-tests revealed no significant differences between cases and controls for log-transformed mean values of any analyte; however, in an adjusted model the odds ratio for autism was 1.91 (p=0.29) and 1.79 (p= 0.36) respectively, for subjects with total PCBs and DDE above the 90th percentile of control values. Levels of prenatal PCB exposure in FIPS-A were similar to levels previously correlated with poorer neurodevelopmental measures in other populations. Further study in a larger sample will be required to fully determine whether exposure to high POP levels are associated with autism diagnosis in the population.

show abstract

Neonatal neurodevelopment and prenatal exposure to dichlorodiphenyldichloroethylene (DDE): A cohort study in Mexico

Cited by 28 publications

References 13 publications

Prenatal Exposure to DDT and Pyrethroids for Malaria Control and Child Neurodevelopment: The VHEMBE Cohort, South Africa

Prenatal Exposure to DDT and Pyrethroids for Malaria Control and Child Neurodevelopment: The VHEMBE Cohort, South Africa

Contributions of a Child’s Built, Natural, and Social Environments to Their General Cognitive Ability: A Systematic Scoping Review

Maternal serum persistent organic pollutants in the Finnish Prenatal Study of Autism: A pilot study

Contact Info

Product

Resources

About