Maternal Arsenic Exposure and Impaired Glucose Tolerance during Pregnancy

Ettinger, Adrienne S.; Zota, Ami R.; Amarasiriwardena, Chitra; Hopkins, Marianne R.; Schwartz, Joel; Hu, Howard; Wright, Robert O.

doi:10.1289/ehp.0800533

Cited by 95 publications

(69 citation statements)

References 24 publications

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“…In one of the first studies to examine the role of As in glucose tolerance, Ettinger et al conducted a cross-sectional study of 532 women living near the Tar Creek Superfund site in Oklahoma. The authors found that the highest quartile of maternal blood As at delivery was associated with impaired glucose tolerance at 24–28 weeks of gestation (OR: 2.8, 95 % CI: 1.1, 6.9) [21]. They also reported that hair As, a long-term biomarker that is similar to toenail As, was associated with a 4-fold increased odds of impaired glucose tolerance (OR: 4.2, 95 % CI: 0.7–23.9), although this was not statistically significant [21].…”

Section: Discussionmentioning

confidence: 99%

“…The authors found that the highest quartile of maternal blood As at delivery was associated with impaired glucose tolerance at 24–28 weeks of gestation (OR: 2.8, 95 % CI: 1.1, 6.9) [21]. They also reported that hair As, a long-term biomarker that is similar to toenail As, was associated with a 4-fold increased odds of impaired glucose tolerance (OR: 4.2, 95 % CI: 0.7–23.9), although this was not statistically significant [21]. These results were similar to our observation of an association between toenail As and GDM.…”

Section: Discussionmentioning

confidence: 99%

“…Although few epidemiological studies have examined As exposure and GDM, data are beginning to emerge on the potential role for As in the development of impaired gestational glucose control [21–23]. Specifically, only three prior studies have examined the association between As and GDM, and of these, two were limited in that they relied solely on postpartum As exposure assessments.…”

Section: Introductionmentioning

confidence: 99%

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Maternal arsenic exposure and gestational diabetes and glucose intolerance in the New Hampshire birth cohort study

et al. 2016

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BackgroundGestational diabetes mellitus (GDM) is a major pregnancy complication with detrimental effects for both mothers and their children. Accumulating evidence has suggested a potential role for arsenic (As) exposure in the development of GDM, but current studies have not assessed As exposure from water, urine or toenail samples.MethodsWe investigated the association between As exposure and risk of glucose intolerance and GDM among 1151 women enrolled in the New Hampshire Birth Cohort Study. Arsenic was measured in home well water and via biomarkers (i.e., maternal urine collected ~24–28 weeks gestation and toenail clippings collected 2 weeks postpartum).ResultsA total of 105 (9.1 %) of women were diagnosed with glucose intolerance and 14 (1.2 %) of women were diagnosed with GDM. A total of 10.3 % of women had water As levels above 10 μg/L, with a mean As level of 4.2. Each 5 μg/L increase in As concentration in home well water was associated with a ~10 % increased odds of GDM (OR: 1.1, 95 % CI 1.0, 1.2). A positive and statistically significant association also was observed between toenail As and GDM (OR: 4.5, 95 % CI 1.2, 16.6), but not urinary arsenic (OR: 0.8, 95 % CI 0.3, 2.4). In a stratified analysis, the association between water As and GDM and glucose intolerance was largely limited to obese women (OR: 1.7, 95 % CI 1.0, 2.8).ConclusionsOur findings support the role of As exposure via water from private wells in the incidence of GDM and that this association may be modified by body composition.Electronic supplementary materialThe online version of this article (doi:10.1186/s12940-016-0194-0) contains supplementary material, which is available to authorized users.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Maternal arsenic exposure and gestational diabetes and glucose intolerance in the New Hampshire birth cohort study

et al. 2016

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“…Women were recruited from 2002 to 2011 at the Integris Baptist Regional Health Center (Miami, OK, USA), the only hospital in Ottawa County, during prenatal visits or at delivery (described in Ettinger et al . 20 ). Eligibility criteria included giving birth at Integris Hospital, intent to live in the area for ≥2 years, no other children concurrently enrolled, and English language proficiency.…”

Section: Methodsmentioning

confidence: 99%

Associations between metals in residential environmental media and exposure biomarkers over time in infants living near a mining-impacted site

Zota

Riederer

Ettinger

et al. 2015

J Expo Sci Environ Epidemiol

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Infant exposures to metals are a concern for mining-impacted communities, although limited information is available to assess residential exposures over the first year of life. We measured lead (Pb), manganese, arsenic, and cadmium in indoor air, house dust, yard soil, and tap water from 53 infants’ homes near the Tar Creek Superfund Site (Oklahoma, USA) at two time points representing developmental stages before and during initial ambulation (age 0–6 and 6–12 months). We measured infant metal biomarkers in: umbilical cord blood (n = 53); 12- (n = 43) and 24- (n = 22) month blood; and hair at age 12 months (n = 39). We evaluated cross-sectional and longitudinal associations between infant residential and biomarker concentrations. A doubling of mean dust Pb concentration was consistently associated with 36–49% higher 12-month blood Pb adjusting for cord blood Pb (P≤ 0.05). Adjusted dust concentration explained 29–35% of blood Pb variance, and consistent associations with other media were not observed. Although concentrations in dust and blood were generally low, strong and consistent associations between dust and body burden suggest that house dust in mining-impacted communities may impact children’s health. These relationships were observed at a young age, typically before blood Pb levels peak and when children’s development may be particularly vulnerable to toxic insult.

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“…Adverse health effects associated with high levels of i-As exposure are well recognized. However, recent studies have reported an elevated risk of certain cancers, cardiovascular diseases, respiratory conditions, and diabetes associated with relatively low levels of i-As exposure (Amaral et al, 2012; EFSA, 2009; Ettinger et al, 2009; Karagas et al, 2004, 2001; Leonardi et al, 2012; Navas-Acien et al, 2008; Sohel et al, 2009). Such associations have been observed in populations who were known to consume water with concentrations of i-As well below the World Health Organization’s guideline of 10 μg/L.…”

Section: Introductionmentioning

confidence: 99%

Assessment of human dietary exposure to arsenic through rice

Davis

Signes-Pastor

Argos

et al. 2017

Science of The Total Environment

109

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Rice accumulates 10-fold higher inorganic arsenic (i-As), an established human carcinogen, than other grains. This review summarizes epidemiologic studies that examined the association between rice consumption and biomarkers of arsenic exposure. After reviewing the literature we identified 20 studies, among them included 18 observational and 2 human experimental studies that reported on associations between rice consumption and an arsenic biomarker. Among individuals not exposed to contaminated water, rice is a source of i-As exposure — rice consumption has been consistently related to arsenic biomarkers, and the relationship has been clearly demonstrated in experimental studies. Early-life i-As exposure is of particular concern due to its association with lifelong adverse health outcomes. Maternal rice consumption during pregnancy also has been associated with infant toenail total arsenic concentrations indicating that dietary exposure during pregnancy results in fetal exposure. Thus, the collective evidence indicates that rice is an independent source of arsenic exposure in populations around the world and highlights the importance of investigating its affect on health.

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Maternal Arsenic Exposure and Impaired Glucose Tolerance during Pregnancy

Cited by 95 publications

References 24 publications

Maternal arsenic exposure and gestational diabetes and glucose intolerance in the New Hampshire birth cohort study

Maternal arsenic exposure and gestational diabetes and glucose intolerance in the New Hampshire birth cohort study

Associations between metals in residential environmental media and exposure biomarkers over time in infants living near a mining-impacted site

Assessment of human dietary exposure to arsenic through rice

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