Maternal anthropometric characteristics in pregnancy and blood pressure among adolescents: 1993 live birth cohort, Pelotas, southern Brazil

Abstract

BackgroundWe investigated the association between maternal anthropometric measurements in prepregnancy and at the end of pregnancy and their children's systolic (SBP) and diastolic (DBP) blood pressure at 11 years of age, in a prospective cohort study.MethodsAll hospital births which took place in 1993 in the city of Pelotas - Brazil, were identified (5,249 live births). In 2004, the overall proportion of follow-up was 85% and we obtained arterial blood pressure measurements of 4,452 adolescents.ResultsIndependent variables analyzed included maternal prepregnancy weight and body mass index (BMI) and maternal weight, and height at the end of pregnancy. Multiple linear regression analysis controlling for the following confounders were carried out: adolescent's skin color, family income at birth, smoking, alcohol intake during pregnancy, and gestational arterial hypertension. Mean SBP and DBP were 101.9 mmHg (SD 12.3) and 63.4 mmHg (SD 9.9), respectively. Maternal prepregnancy weight and BMI, and weight at the end of pregnancy were positively associated with both SBP and DBP in adolescent subjects of both sexes; maternal height was positively associated with SBP only among males.ConclusionsAdequate evaluation of maternal anthropometric characteristics during pregnancy may prevent high levels of blood pressure among adolescent children.

Maternal obesity and the developmental programming of hypertension: a role for leptin

“…Compared with childhood adiposity/BMI, the relationship between maternal BMI and childhood cardiovascular function has infrequently been addressed and is almost exclusively confined to measurement of blood pressure; however, several mother–child cohort studies now report independent relationships between maternal BMI and blood pressure in older children and adolescents (Laura et al . , Filler et al . , Wen et al .…”

“…Maternal pre-pregnancy obesity vs. GWG and cardiovascular risk of offspring Compared with childhood adiposity/BMI, the relationship between maternal BMI and childhood cardiovascular function has infrequently been addressed and is almost exclusively confined to measurement of blood pressure; however, several mother-child cohort studies now report independent relationships between maternal BMI and blood pressure in older children and adolescents (Laura et al 2010, Filler et al 2011, Wen et al 2011, Hochner et al 2012. A recent study has also observed that maternal pre-pregnancy obesity/ overweight is associated with increased systolic blood pressure (SBP) in 7-year-old children (Wen et al 2011).…”

Chronic Hypertension in Women after Perinatal Exposure to Preeclampsia, Being Born Small for Gestational Age or Preterm

“…Smoking and BMI in the women of the second generation might affect the outcome of the study. 18,19 However, both these covariates were only available in Sweden for women being pregnant in 1992 or later (n = 397 063). In a supplementary analysis, we only included women from the Swedish MBR that gave birth in 1992 or later, where data on smoking habits as well as BMI were available (n = 353 976).…”

“…Smoking and BMI in the women of the second generation might affect the outcome of the study . However, both these covariates were only available in Sweden for women being pregnant in 1992 or later ( n = 397 063).…”

Early Life Influences and Type-2 Diabetes – A Review

“…Indian women are by nature shorter than peers elsewhere and the 'maternal constraint' imposed by physical stature (shorter height), pelvic size and lifetime reserves of metabolic substrates can impact the next generation through effects on offspring birth size, linear growth and future biomarkers for metabolic disease 22,51,52 . Pre-pregnancy maternal weight, weight gain during pregnancy and own birth weight of the parents are all shown to be positively associated with offspring birth weight, body composition and insulin resistance in childhood and later life 12,[52][53][54][55][56] .…”